Epicardial Adipose Tissue As Target of the Incretin-Based Therapies in Cardio-Metabolic Pathologies: A Narrative Review [0.03%]
在心血管代谢疾病中作为肠促胰岛素类疗法靶点的间皮下脂肪组织：一项叙述性综述
Andrea Sk Pop,Maria D Danila,Silvia Giuchici et al.
Andrea Sk Pop et al.
The epicardial adipose tissue (EAT) serves in physiological conditions as a mechanical and thermal myocardial protective layer, as well as a readily available lipid-storage unit. In pathological conditions, EAT expansion becomes deleterious...
Systematic Review of Health Canada Authorized Clinical Therapeutic Trials for the Treatment or Prevention of Coronavirus Disease 2019 (COVID-19) [0.03%]
加拿大卫生部授权的用于治疗或预防新型冠状病毒疾病2019(COVID-19)的临床治疗试验系统回顾
Antonios M Diab,Hailey Stack,Brendan T McKeown et al.
Antonios M Diab et al.
In response to the COVID-19 pandemic, Canadian clinical researchers pivoted their research programs to investigate repurposing drugs, accelerating the development of experimental therapies, and developing novel disease-specific treatments. ...
Examining tissue-level changes in Doxorubicin accumulation and Nitric Oxide formation in skeletal muscle and tumours in a mouse model of breast cancer [0.03%]
在乳腺癌小鼠模型中检查多柔比星积聚和一氧化氮形成过程中的组织水平变化
Meghan Victoria McCue,Irena A Rebalka,Tom Hawke et al.
Meghan Victoria McCue et al.
Introduction: Doxorubicin is a commonly used chemotherapy that rapidly accumulates in skeletal muscle and disrupts nitric oxide (NO) formation. However, studies investigating these effects have largely been performed in t...
Causality Assessment of Adverse Events by Healthcare Professionals in an Academic Hospital Setting: A Descriptive Retrospective Study [0.03%]
学术医院环境下医务人员不良事件因果关系评定的描述性回顾研究
Sonia Corbin,Maude Lavallée,Pallavi Pradhan et al.
Sonia Corbin et al.
Background: Assessing the causality of a drug product-related adverse event (AE) is a very important aspect of pharmacovigilance. However, it is unclear whether AEs are investigated for causality in a hospital setting. ...
Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats [0.03%]
婴儿大鼠切片中组胺H3受体的激活增加纹状体中型多棘神经元的放电次数
Carolina González-Sandoval,Isabel Godínez-Ramos,José-Antonio Arias-Montaño et al.
Carolina González-Sandoval et al.
Striatal medium spiny neurons (MSN) form two subpopulations (MSN-D1 and MSN-D2) according to the expression of dopamine D1 or D2 receptors and their target regions. The activation of postsynaptic histamine H1 and H2 receptors increases MSN-...
Vitamin C protects against doxorubicin induced skeletal muscle atrophy: Role of oxidative stress [0.03%]
维生素C通过抗氧化应激保护多柔比星所致骨骼肌萎缩作用机制研究
Antonio Viana do Nascimento Filho,Filipe Fernandes Stoyell-Conti,Akolkar Gauri et al.
Antonio Viana do Nascimento Filho et al.
Doxorubicin is known for its significant cardiotoxicity, driven in part by elevated oxidative stress (OS). Furthermore, preclinical models have demonstrated that doxorubicin induces skeletal muscle atrophy. While vitamin C has been recogniz...
The Addictive Process of Opioids: Current and Novel Interventions in Opioid Use Disorder [0.03%]
阿片类药物的成瘾过程：阿片类药物使用障碍的当前和新型干预措施
James Duerksen,Matthew Ramjiawan,Julia Witt et al.
James Duerksen et al.
The growing epidemic of opioid misuse presents numerous challenges for healthcare practitioners and patients alike as friction exists between ease of use and efficacy, and potential for overuse and addiction. With over 82,000 deaths related...
A review of the common causes of acute coronary syndrome (ACS) in females, and the role of estrogen on its pathologies and risk factors [0.03%]
女性急性冠脉综合征的常见病因及雌激素的作用机制和风险因素研究进展
Jenny Youn Namkoong,Kunal Minhas
Jenny Youn Namkoong
As our understanding of acute coronary syndromes (ACS) has increased, we have been able to better delineate the unique pathologies that cause ACS. This review article on the common causes of ACS in females explores the atherosclerotic patho...
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation [0.03%]
心脏干细胞抗原1表达细胞的内皮特征及其对右心室适应性的相关性研究
Kirishani Kesavan,Sheethal Panchakshari,Haya AbdelWahab et al.
Kirishani Kesavan et al.
A growing body of evidence suggest that the stem cell antigen-1 expressing (Sca-1+) cells in the heart may be the cardiac endothelial stem/progenitor cells. Their endothelial cell (EC) functions, and their role in RV physiology and pathophy...
Effects of Acute Aerobic Exercise on Skeletal Muscle and Liver Glucose Metabolism in Male Rodents with Type 1 Diabetes [0.03%]
急性有氧运动对1型糖尿病雄性 rodents骨骼肌和肝脏糖代谢的影响
Justin Camenzuli,Mitchell Sammut,Theres Tijo et al.
Justin Camenzuli et al.
Aerobic exercise (AE) is associated with a significant hypoglycemia risk in individuals with type 1 diabetes mellitus (T1DM). However, the mechanisms in the liver and skeletal muscle governing exercise-induced hypoglycemia in T1DM are poorl...