Adrián Rivera-Ruedas,Alejandro R Medina-Vilchis,Juan J Romero-Tovar et al.
Adrián Rivera-Ruedas et al.
Pharmacological targeting of ion channels represents a crucial avenue for pain management. The KCNQ family of ion channels plays a significant role controlling neuronal excitability and the generation and propagation of pain-related nerve i...
Repurposing Incretin Therapies: A Narrative Review of Emerging Indications Across Cardiometabolic, Liver, Kidney, Neurological, Psychiatric, and Other Systems [0.03%]
肠降糖激素治疗的再利用：心血管代谢、肝脏、肾脏、神经学、精神病学和其他系统新兴适应症叙述性综述
Ibrahim S Alhomoud,Sarah E Wheeler,Dave L Dixon
Ibrahim S Alhomoud
Incretin therapies have revolutionized the management of type 2 diabetes and obesity. Recent evidence suggests that these agents modulate key pathways involved in cardiovascular, renal, hepatic, neuropsychiatric, and reproductive health. In...
Disproportionality Analysis of ALK Inhibitor-Induced Hemolytic Adverse Events: A Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database [0.03%]
基于FDA不良事件报告系统数据库的ALK抑制剂所致溶血不良反应 disproportionality 分析：一项药物警戒研究
Connor Frey
Connor Frey
Objective: ALK inhibitors have transformed treatment for ALK-rearranged malignancies, particularly NSCLC, by disrupting oncogenic signalling. However, hematologic adverse effects, including hemolysis, have emerged as conc...
Maternal high fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring [0.03%]
母体高脂肪饮食可致雄性子代成年期气道反应性增强和支气管舒张反应受损
Luiz Otávio Lourenço,Évila da Silva Lopes Salles,Ricardo Murilo Pereira Emídio et al.
Luiz Otávio Lourenço et al.
Obesity induced by a high-fat diet (HFD) is a growing global health concern, often linked to numerous metabolic and respiratory disorders. This study investigates the impact of a maternal HFD on the respiratory physiology of adult offspring...
Bin Yu,Xuelian Li,Li Yang et al.
Bin Yu et al.
Sepsis is an organ dysfunction caused by the body's dysfunctional response to infection, which is one of the most important causes of death in critically ill patients. It is characterized by high morbidity, high mortality and high treatment...
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats [0.03%]
芸香苷通过改善线粒体功能防治糖尿病大鼠肝损伤
María A Rizzi,Adriana Pérez,Solange Guizzardi et al.
María A Rizzi et al.
We previously demonstrated that naringin (NAR) protects against liver damage in streptozotocin (STZ)-induced diabetes in rats. The aim of this study was to elucidate whether NAR is also able to protect the functioning, biogenesis and dynami...
Exploring the supraspinal antihyperalgesic effects of levetiracetam in the rat model of chronic constriction injury [0.03%]
利培酮在慢性约束损伤大鼠模型中的抗高敏效应及机制研究
Feyza Alyu,Michele Petrella,Alessio Masi et al.
Feyza Alyu et al.
Neuropathic pain severely impacts quality of life and effective treatments are needed. To address this, the present study investigated the antihyperalgesic mechanisms of levetiracetam administered at the supraspinal level, together with its...
White matter microglia morphological changes with aging in guinea pig offspring born growth restricted [0.03%]
宫内生长受限 Guinea Pig后代随龄脑白质小胶质细胞形态学变化研究
Timothy B Nunes,Karen L Nygard,Marc C J Courchesne et al.
Timothy B Nunes et al.
Fetal growth restriction is implicated in the programming of later-life neurodegeneration. We hypothesized that growth-restricted offspring would show accelerated changes to microglial white matter morphology, relative to controls. Control ...
Nampt as a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular and neurodegenerative diseases [0.03%]
靶向NAMPT调控烟酸辅酶NAD+水平以治疗代谢、心血管和神经退行性疾病
Ravikumar Manickam,Sandhya Santhana,Wanling Xuan et al.
Ravikumar Manickam et al.
NAD+ is an important cofactor involved in regulating many biochemical processes in cells. An imbalance in NAD+/NADH ratio is linked to many diseases. NAD+ is depleted in diabetes, cardiovascular and neurodegenerative diseases, and in aging,...
Polygenic scores of obesity in childhood based on summary statistics from adults vs. children [0.03%]
基于成人和儿童汇总统计数据的童年期肥胖多基因分数分析
Danick Goulet,Michel Boivin,Christopher Gravel et al.
Danick Goulet et al.
The lack of polygenic scores (PGSs) developed for body-mass index (BMI) in children may be problematic because the genetic architecture characterizing BMI changes throughout life. This study aims to describe the genetic susceptibility to ob...