Cannabivarin and Tetrahydrocannabivarin Modulate Nociception via Vanilloid Channels and Cannabinoid-Like Receptors in Caenorhabditis elegans [0.03%]
大麻叶环烯醚萜类生物碱通过大麻素受体样物质和香草胺通道调节疼痛：在秀丽隐杆线虫中的研究
Nasim Rahmani,Jesus David Castano Uruena,Francis Beaudry
Nasim Rahmani
Cannabis has attracted growing interest for its therapeutic potential, especially in pain management. This study explores the antinociceptive effects of two promising non-psychoactive cannabinoids, cannabivarin (CBV) and tetrahydrocannabiva...
Clozapine and Pharmacogenomics Testing: Opportunities and Challenges for Personalized Treatment in Schizophrenia [0.03%]
氯氮平与药物基因组检测：精神分裂症个性化治疗的机遇与挑战
Muhammad Abdur Rahman Khoodoruth,Mohamed Adil Shah Khoodoruth
Muhammad Abdur Rahman Khoodoruth
Clozapine remains the gold standard for treatment-resistant schizophrenia (TRS), offering unparalleled efficacy but accompanied by significant interindividual variability in response and risk of severe adverse effects. Pharmacogenomics (PGx...
High fructose consumption induces cardiac dysfunction and vascular abnormalities [0.03%]
高果糖摄入诱发心脏功能障碍和血管异常
Paramjit S Tappia,Elle Garriock,Bram Ramjiawan et al.
Paramjit S Tappia et al.
Fructose, is a simple sugar or monosaccharide, which is abundant in nature and commonly used in food industry as a strong natural sweetener. The growing epidemic of high fructose consumption has been linked to increased prevalence of obesit...
Redox Homeostasis and Therapeutic Modulation: The Central Role of Oxidative Stress and Nuclear factor erythroid 2-related factor 2 (Nrf2) Activation in Systemic Diseases and Reproductive Dysfunction [0.03%]
红氧化态稳态及治疗调节：氧化应激和核因子E2相关因子2（Nrf2）激活在系统性疾病与生殖功能障碍中的中心作用
Abhishek Kumar,Sivaraman Ramanarayanan
Abhishek Kumar
Oxidative stress plays a critical role in the pathogenesis of various diseases.In systemic conditions such as neurodegenerative, cardiovascular, metabolic, and oncological disorders, ROS function both as signaling molecules and mediators of...
Effect of Slow Release Hydrogen Sulfide Donor GYY4137 on Vascular Smooth Muscle and Endothelial Response in an In Vitro Ischemia-Reperfusion Model of Rat Thoracic Aorta [0.03%]
慢释型供氢硫化合物GYY4137对在体外缺血再灌注模型中大鼠胸主动脉血管平滑肌和内皮反应的影响
Ariyan Teimoori,Halit Güner Orhan,Nargiz Zeynalova et al.
Ariyan Teimoori et al.
Ischemia-reperfusion (IR) injury of vascular grafts used in coronary artery bypass surgery can compromise outcomes. This study examined whether GYY4137, a slow-release hydrogen sulfide donor, protects against IR-induced vascular damage in r...
High-Sensitivity Troponin I Guided Cardiovascular Risk Assessment in a General Asymptomatic Population: A Cost-Effectiveness Analysis in 4000 Adults [0.03%]
基于高敏肌钙I的心血管风险评估在一般无症状人群中的成本效益分析：一项针对4000名成年人的研究
Goran Krstačić,Antonija Krstačić,Tin Krstačić
Goran Krstačić
Background: High-sensitivity cardiac troponin I (hs-TnI) is a promising biomarker for cardiovascular disease (CVD) risk stratification. This study assessed clinical outcomes and cost-effectiveness of an hs-TnI guided CVD ...
Exposure levels and target attainment of meropenem in adult patients admitted to the intensive care unit: a prospective observational study [0.03%]
甲硝唑联合氟尿嘧啶治疗肛周脓肿的临床疗效及安全性分析——随机对照试验研究报告
Ibrahim El-Haffaf,Amélie Marsot,Alice Paillault et al.
Ibrahim El-Haffaf et al.
Purpose: To evaluate the exposure and pharmacokinetic/pharmacodynamic target attainment of meropenem in critically ill patients. Methods: ...
Exogenous and endogenous antioxidants (ROS) in Physiology and Pathology of the Cardiovascular System [0.03%]
心血管系统的生理和病理中的外源性和内源性抗氧化剂（ROS）
Ghassan Bkaily,Danielle Jacques,Ashley Jazzar
Ghassan Bkaily
Generation of reactive oxygen species (ROS) is a physiological product of cell activity that is mainly generated by the mitochondria as well as by transmembrane NADPH oxidases (NOX1-5) present at the plasma and nuclear envelope membranes. T...
ANTI-INFLAMMATORY PROPERTIES OF GLP-1 RECEPTOR AGONISTS AND OTHER ANCILLARY BENEFITS FROM A PHARMACOLOGICAL PERSPECTIVE [0.03%]
从药理学角度看胰高糖素样肽1受体激动剂的抗炎特性及其他潜在益处
Inmaculada Ros-Madrid,Rosario Paloma Cano-Mármol,Mercedes Ferrer-Gómez et al.
Inmaculada Ros-Madrid et al.
Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1RAs), exert a wide range of beneficial effects beyond glycemic control, largely mediated by their anti-inflammatory properties. Chronic low-grade inflamm...
Association of blood pressure with nonalcoholic fatty liver disease defined by fatty liver index [0.03%]
血压与血清脂肪肝指数定义的非酒精性脂肪肝的关系
Anastasiya M Kaneva,Evgeny R Bojko
Anastasiya M Kaneva
Despite the known association between hypertension and nonalcoholic fatty liver disease (NAFLD), the cut-off values of blood pressure for identifying risk of NAFLD have not yet been determined. The aim of this study was to determine the dia...