Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice [0.03%]
甲状腺激素诱导β1肾上腺素能受体敲除小鼠发生限制型心肌病
Anderson L B da Silveira,Fernando A C Seara,Danilo Lustrino et al.
Anderson L B da Silveira et al.
The purpose of this study was to characterize the role of β1-AR signaling and its cross-talk between cardiac renin-angiotensin system and thyroid-hormone-induced cardiac hypertrophy. T3 was administered at 0.5 mg·kg-1·day-1 for 10 days i...
MiR-122 knockdown regulates vascular smooth muscle cells phenotypic switching through enhanced FOXO3 expression [0.03%]
miR-122敲低通过增强FOXO3的表达调控血管平滑肌细胞表型转换
Lan Zhang,Qian-Wei Huang,Yan-Fen Pu et al.
Lan Zhang et al.
Vascular smooth muscle cells (VSMCs) phenotypic switching is identified as enhanced dedifferentiation, proliferation, and migration ability of VSMCs, in which microRNAs have been identified as important regulators of the process. The presen...
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension [0.03%]
热量限制可改善肥胖和2K1C肾血管性高血压大鼠不同组织的炎症反应
Thayane Rafaela Feola Pizzo,Ana Paula Valverde,Lucas Eduardo Orzari et al.
Thayane Rafaela Feola Pizzo et al.
Renovascular hypertension (RHV) is the cause of high blood pressure due to left renal ischemia, and obesity and hypertension cause an inflammatory response. This work analyzed the inflammatory and tissue repair profile in renal, hepatic, an...
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy [0.03%]
肿瘤对免疫因素的适应：癌症免疫治疗的新旧思路
I Yu Malyshev,O P Budanova,L V Kuznetsova
I Yu Malyshev
The tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth...
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients [0.03%]
口服与静脉注射维生素D3对2型糖尿病患者核因子-κB及血小板聚集的影响
Esraa Habiba,Samia Ali,Yehia Ghanem et al.
Esraa Habiba et al.
Platelet hyperactivity is one of the key factors implicated in the development and progression of diabetic vascular complications. Activated platelets mediate leukocyte recruitment that further enhances inflammatory responses in vascular wa...
Randomized Controlled Trial
Canadian journal of physiology and pharmacology. 2023 Nov 1;101(11):610-619. DOI:10.1139/cjpp-2022-0359 2023
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report [0.03%]
加强肾脏清除率患者β内酰胺类抗生素治疗药物监测的潜在益处：一例报告
Ibrahim El-Haffaf,Jean Laverdière,Martin Albert et al.
Ibrahim El-Haffaf et al.
Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of piperacill...
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma [0.03%]
结肠腺癌中与铜死亡相关的基因预后标志物研究
Yongqin Su,Kun Zhang
Yongqin Su
Cuproptosis is the latest cell death type caused by enhanced mitochondrial-dependent energy metabolism. This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CR...
α-Tocopherol reduces VLDL secretion through modulation of intracellular ER-to-Golgi transport of VLDL [0.03%]
α-生育酚通过调节细胞内ER至高尔基体的VLDL运输来减少VLDL分泌
Ryan Clay,Shaila Siddiqi,Shadab A Siddiqi
Ryan Clay
Avoiding hepatic steatosis is crucial for preventing liver dysfunction, and one mechanism by which this is accomplished is through synchronization of the rate of very low density lipoprotein (VLDL) synthesis with its secretion. Endoplasmic ...
Faezeh Lorestani,Ahmad Movahedian,Adel Mohammadalipour et al.
Faezeh Lorestani et al.
Renal toxicity is one of the side effects of methotrexate (MTX). Therefore, this study explored the use of astaxanthin (AST), as a natural carotenoid, against MTX-induced nephrotoxicity emphasizing the changes in oxidative stress and the ex...
Simultaneous intervention against oxidative stress and inflammation by targeting Nrf2/ARE and NLRP3 inflammasome pathway mitigates thioacetamide-induced liver fibrosis in rat [0.03%]
通过靶向Nrf2/ARE和NLRP3炎性小体途径同时对抗氧化应激和炎症缓解硫代乙酰胺诱导的大鼠肝纤维化
Durgesh Kumar Dwivedi,Chittaranjan Sahu,G B Jena
Durgesh Kumar Dwivedi
Liver fibrosis is a typical pathological state/stage involved in most chronic liver diseases and its persistence results in cirrhosis. Inflammasomes are cytoplasmic sensors that induce inflammation in response to stress. Glibenclamide (GLB)...