Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta [0.03%]
咪达唑仑，氟马泽林和新型imidazobenzodiazepine MP-III-058对分离的鼠主动脉的作用
Milica Gajić Bojić,Marco Treven,Kamal P Pandey et al.
Milica Gajić Bojić et al.
Hypotensive influences of benzodiazepines and other GABAA receptor ligands, recognized in clinical practice, seem to stem from the existence of "vascular" GABAA receptors in peripheral blood vessels, besides any mechanisms in the central an...
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics [0.03%]
心血管再生治疗的直接细胞重编程技术
Xingyu He,Suchandrima Dutta,Jialiang Liang et al.
Xingyu He et al.
Cardiovascular diseases remain a leading cause of hospitalization affecting approximately 38 million people worldwide. While pharmacological and revascularization techniques can improve the patient's survival and quality of life, they canno...
Unveiling the antibacterial and antioxidant potential of Hedera helix leaf extracts: recent findings [0.03%]
络石叶提取物的抗菌和抗氧化潜力：最近的研究成果
Khaled Qabaha,Jehad Abbadi,Reem Yaghmour et al.
Khaled Qabaha et al.
Hedera helix L., a member of the Araliaceae family, is a commonly known decorative plant with recognized medicinal activities. In this study, the ethanolic extract from H. helix leaves was investigated for its total polyphenolic and flavono...
PRIMA-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis [0.03%]
PRIMA-1协同增强olaparib诱导的p53突变三阴性人类乳腺癌细胞系细胞死亡通过恢复p53功能，阻滞细胞周期和诱导凋亡
Mohamed Zaza,Mohammed H Rashed,Hesham Elrefaey et al.
Mohamed Zaza et al.
This study concerned with assessing the effect of restoring p53 using PRIMA-1 on the anti-cancer activity of olaparib against TP53-mutant triple negative breast cancer (TNBC) cells and exploring the optimum synergistic concentrations and th...
The impact of ionizing radiation compared to drug-induced immunological changes [0.03%]
电离辐射的影响与药物诱导的免疫学变化的影响相比如何
Soha M Hussien
Soha M Hussien
Ionizing radiation (IR) activates several signaling pathways. This study shows the impact of acute low-dose IR on crucial cytokines involved in cell-mediated immunity. The immunomodulatory effects of 0.25 and 0.5 Gray (Gy) gamma rays and st...
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications [0.03%]
PCSK9在糖尿病并发症中的作用
Omonzejie E Imaralu,Chandrakala Aluganti Narasimhulu,Pawan K Singal et al.
Omonzejie E Imaralu et al.
Cardiovascular disease (CVD) complications have remained a major cause of death among patients with diabetes. Hence, there is a need for effective therapeutics against diabetes-induced CVD complications. Since its discovery, proprotein conv...
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway [0.03%]
RAD54B通过抑制CHK1/p53/p21信号通路抑制血管内皮细胞衰老
Yanqi Mai,Tong Lin,Lili Zhang et al.
Yanqi Mai et al.
RAD54B belongs to the SNF2/SWI2 superfamily, participating in homologous recombination repair. DNA damage is the central driver of aging, but there is no direct evidence of an association between RAD54B and vascular aging. The present study...
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure [0.03%]
血管紧张素受体在心脏肥大和心力衰竭发展中的适应性和非适应性作用
Sukhwinder K Bhullar,Naranjan S Dhalla
Sukhwinder K Bhullar
Angiotensin II (Ang II) is formed by the action of angiotensin-converting enzyme (ACE) in the renin-angiotensin system. This hormone is known to induce cardiac hypertrophy and heart failure and its actions are mediated by the interaction of...
The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52 [0.03%]
甜味剂蔗糖素通过非麦孤独肽受体GPR52促进β-阻滞蛋白信号转导
Madeline E Power,Nicholas R Fernandez,Olaiya Peter Oni et al.
Madeline E Power et al.
Non-nutritive sweeteners are popular food additives owing to their low caloric density and powerful sweetness relative to natural sugars. Their lack of metabolism contributes to evidence proclaiming their safety, yet several studies contrad...
Considerations for choosing an optimal animal model of cardiovascular disease [0.03%]
选择心血管疾病理想动物模型的考虑因素
Mihir Parikh,Grant N Pierce
Mihir Parikh
The decision to use the optimal animal model to mimic the various types of cardiovascular disease is a critical one for a basic scientist. Clinical cardiovascular disease can be complex and presents itself as atherosclerosis, hypertension, ...