Preventing broken hearts in women with breast cancer: a concise review on chemotherapy-mediated cardiotoxicity [0.03%]
化疗致心脏毒性的防治：乳腺癌患者的心脏保护策略综述
Hilary J Bews,Lana Mackic,Davinder S Jassal
Hilary J Bews
Cancer and cardiovascular disease are the leading causes of death for Canadian women. One in eight Canadian women will receive the life-changing diagnosis of breast cancer (BC) in their lifetime, with 1 in 34 dying from the disease. Althoug...
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa [0.03%]
公猪精子质膜Na⁺K⁺-ATP酶的存在及其重要性
Basim J Awda,Ian V Mahoney,Murray Pettitt et al.
Basim J Awda et al.
Sodium-potassium-ATPase (Na+K+-ATPase), a target to treat congestive heart failure, is the only known receptor for cardiac glycosides implicated in intracellular signaling and additionally functions enzymatically in ion transport. Spermatoz...
Efficacy and safety of fenofibrate in combination with phototherapy for the treatment of neonatal hyperbilirubinemia: a systematic review and meta-analyses [0.03%]
非诺贝特联合光疗治疗新生儿高胆红素血症的疗效和安全性：系统评价和-meta分析
Mohammed Abdellatif,Ali Ahmed Fouad Abozaid,Prakesh S Shah et al.
Mohammed Abdellatif et al.
Phototherapy is the standard treatment for neonatal jaundice. We aimed to review the efficacy and safety of fenofibrate as an adjunct therapy. Twelve databases were searched and a systematic review and meta-analysis were conducted. Mean cha...
Deciphering MMP9's dual role in regulating SOD3 through protein-protein interactions [0.03%]
蛋白质-蛋白质相互作用在MMP9调节SOD3中的双重作用机制解析
Flobater I Gawargi,Paras K Mishra
Flobater I Gawargi
Although the collagenase enzyme activity of matrix metalloproteinase-9 (MMP9) is well-documented, its non-enzymatic functions remain less understood. The interaction between intracellular superoxide dismutase-1 (SOD1) and MMP9 is known, wit...
Role of circadian clock system in the mitochondrial trans-sulfuration pathway and tissue remodeling [0.03%]
昼夜钟系统在线粒体交联转硫途径和组织重塑中的作用
Suresh C Tyagi,Sathnur Pushpakumar,Utpal Sen et al.
Suresh C Tyagi et al.
Previous studies from our laboratory revealed that the gaseous molecule hydrogen sulfide (H2S), a metabolic product of epigenetics, involves trans-sulfuration pathway for ensuring metabolism and clearance of homocysteine (Hcy) from body, th...
Nitric oxide and potassium channels but not opioid and cannabinoid receptors mediate tramadol-induced peripheral antinociception in rat model of paw pressure withdrawal [0.03%]
硝酸盐和钾通道但不是阿片受体和大麻素受体介导tramadol诱导的足压撤回痛觉减退模型大鼠的外周抗痛觉作用
Raquel R Soares-Santos,Daniel P Machado,Thiago L Romero et al.
Raquel R Soares-Santos et al.
Tramadol, an analgesic classified as an "atypical opioid", exhibits both opioid and non-opioid mechanisms of action. This study aimed to explore these mechanisms, specifically the opioid-, cannabinoid-, nitric oxide-, and potassium channel-...
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice [0.03%]
Sclerostin注射对雄性小鼠腓肠肌和趾长伸肌肌组织的影响
Joshua Stoikos,Nigel Kurgan,Steven Kottaras et al.
Joshua Stoikos et al.
Sclerostin, a potent inhibitor of the Wnt signaling pathway, plays a critical role in bone homeostasis. Evidence suggests that sclerostin may also be involved in crosstalk between other tissues, including muscle. This pilot study attempted ...
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission [0.03%]
穿心莲内酯丁素通过调节炎症和脊髓兴奋性突触传递来缓解神经病理性疼痛
Dongxia Duan,Lian Wang,Yueyang Feng et al.
Dongxia Duan et al.
Nerve injury induced microglia activation, which released inflammatory mediators and developed neuropathic pain. Picroside Ⅱ (PⅡ) attenuated neuropathic pain by inhibiting the neuroinflammation of the spinal dorsal horn; however, how it e...
TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia [0.03%]
模式识别受体TLR和mTOR炎症信号通路在精神分裂症发病机制中的作用及展望
Naser-Aldin Lashgari,Nazanin Momeni Roudsari,Hedieh Sadat Shamsnia et al.
Naser-Aldin Lashgari et al.
The Toll-like receptor (TLR)/mammalian target of rapamycin (mTOR) signaling pathway is involved in the intracellular regulation of protein synthesis, specifically the ones that mediate neuronal morphology and facilitate synaptic plasticity....
SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression [0.03%]
SCH772984通过逆转MEK/ERK/Foxo1介导的糖异生抑制来改善脂多糖诱导的小鼠低血糖症
Yirong Wang,Shuyun Qing,Jing Yang et al.
Yirong Wang et al.
Lipopolysaccharide (LPS) results in a lethal hypoglycemic response. However, the main molecular mechanism involved in LPS-induced glucose metabolism disorder is poorly understood. This study intends to investigate the signaling pathways inv...