Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress [0.03%]
产前地塞米松暴露对成年C57BL / 6J小鼠的代谢和氧化应激的影响
A S Nemec-Bakk,J Bel,S Niccoli et al.
A S Nemec-Bakk et al.
Prenatal glucocorticoid exposure has been shown to alter hypothalamic-pituitary-adrenal axis function resulting in altered fetal development that can persist through adulthood. Fetal exposure to excess dexamethasone, a synthetic glucocortic...
The influence of estrogen on myocardial post-translational modifications and cardiac function in women [0.03%]
雌激素对女性心肌蛋白质翻译后修饰及心脏功能的影响
Samantha K Shorthill,Timothy L M Jones,Kathleen C Woulfe et al.
Samantha K Shorthill et al.
The lifetime risk of heart failure (HF) is comparable in men and women; nevertheless, disparities exist in our understanding of how HF differs between sexes. Several differences in cardiac physiology exist between men and women including th...
Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro [0.03%]
布托啡诺抑制雄性大鼠不成熟莱迪细胞中的雄激素生物合成和代谢
Changchang Li,Lei Shi,Ming Su et al.
Changchang Li et al.
Butorphanol is a synthetic opioid analgesic medication that is primarily used for the management of pain. Butorphanol may have an inhibitory effect on androgen biosynthesis and metabolism in rat immature Leydig cells. The objective of this ...
Jaideep Kaur Gill,Sargun Kaur Rehsia,Elika Verma et al.
Jaideep Kaur Gill et al.
Cardiac disorders remain the leading cause of mortality worldwide. Current clinical strategies, including drug therapy, surgical interventions, and organ transplantation offer limited benefits to patients without regenerating the damaged my...
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells [0.03%]
揭开糖尿病和心血管疾病之间的联系：脂肪源干细胞的启示
Megan B Meechem,Anshul S Jadli,Vaibhav B Patel
Megan B Meechem
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. The escalating global occurrence of obesity and diabetes mellitus (DM) has led to a significant upsurge in individuals afflicted with CVDs. As the p...
Azilsartan prevents muscle loss and fast- to slow-twitch muscle fiber shift in natural ageing sarcopenic rats [0.03%]
奥利沙坦预防自然衰老的衰弱大鼠肌肉减少和快肌向慢肌转化作用的研究
Priyanka Prajapati,Anand Kumar,Shubhada Mangrulkar et al.
Priyanka Prajapati et al.
Sarcopenia is a musculoskeletal disease that reduces muscle mass and strength in older individuals. The study investigates the effects of azilsartan (AZL) on skeletal muscle loss in natural sarcopenic rats. Male Sprague-Dawley rats aged 4-6...
Formation of a border ischemic zone depends on plasma potassium concentration [0.03%]
边缘缺血区的形成依赖于血浆钾浓度水平
Olesya Bernikova,Aleksandra Durkina,Mikhail Gonotkov et al.
Olesya Bernikova et al.
Extracellular potassium concentration might modify electrophysiological properties in the border zone of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] va...
The role of melatonin in preventing amiodarone-induced rat liver damage [0.03%]
褪黑素对氨氯地平诱导的大鼠肝损伤的预防作用
Dejan Petrović,Marina Deljanin Ilić,Dejan Simonović et al.
Dejan Petrović et al.
Long-term exposure to amiodarone, an antiarrhythmic drug, can induce different organ damage, including liver. Cell damage included by amiodarone is a consequence of mitochondrial damage, reactive oxygen species production, and cell energy d...
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity [0.03%]
salvianolic酸B通过缓解炎性小体中的ADORA2B、NALP3和NFκB活性来减轻糖尿病肾病
Ying Wang,Jiang Chang,Shubin Qiao et al.
Ying Wang et al.
Diabetic nephropathy is one of the microvascular complications of diabetes. This study is aimed at investigating the role and mechanisms of salvianolic acid B (Sal B) in diabetic nephropathy. High glucose (HG)-induced human renal tubular ep...