Poststroke cognitive impairment and dementia: prevalence, diagnosis, and treatment [0.03%]
卒中后认知障碍和痴呆：流行病学、诊断与治疗
Susanna Melkas,Hanna Jokinen,Marja Hietanen et al.
Susanna Melkas et al.
Three aspects of poststroke cognitive impairment and dementia are discussed in this review: prevalence; diagnosis; and treatment. The aim is to increase awareness of poststroke cognitive impairment in order to further stimulate strategies t...
Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease [0.03%]
β-分泌酶抑制剂在阿尔茨海默病治疗中的应用分析
Genevieve Evin,Adel Barakat
Genevieve Evin
Alzheimer's disease (AD) is the major cause of dementia in the elderly and an unmet clinical challenge. A variety of therapies that are currently under development are directed to the amyloid cascade. Indeed, the accumulation and toxicity o...
Re-Evaluating the Use of IFN-β and Relapsing Multiple Sclerosis: Safety, Efficacy and Place in Therapy [0.03%]
干扰素β与复发性多发性硬化症：安全性、疗效和治疗地位的再评价
Carolyn H Goldschmidt,Le H Hua
Carolyn H Goldschmidt
The advent of interferon therapy for the treatment of multiple sclerosis (MS) was a massive advancement in the field and changed the course of the disease. While the exact mechanism of interferon therapy in MS is unknown, disease control is...
Dysphagia In Multiple Sclerosis Patients: Diagnostic And Evaluation Strategies [0.03%]
多发性硬化患者吞咽困难的诊断及评估策略
Noureddin Nakhostin Ansari,Maryam Tarameshlu,Leila Ghelichi
Noureddin Nakhostin Ansari
Dysphagia after multiple sclerosis (MS) is a common disabling symptom which can lead to serious complications. Regular screening and assessment of dysphagia in patients with MS are important. Using valid and reliable instruments to measure ...
Hamidreza Famitafreshi,Morteza Karimian
Hamidreza Famitafreshi
Neurologic and neuropsychiatric diseases are associated with great morbidity and mortality. Prostaglandins (PGs) are formed by sequential oxygenation of arachidonic acid in physiologic and pathologic conditions. For the production of PGs cy...
Jill Rasmussen,Haya Langerman
Jill Rasmussen
Alzheimer's disease is the leading cause of dementia. However, neither Alzheimer's disease nor Alzheimer's dementia are an inevitable consequence of aging. This review provides an overview of the issues involved in a diagnosis of Alzheimer'...
Marge Kartau,Jussi Ot Sipilä,Eeva Auvinen et al.
Marge Kartau et al.
Cases of PML should be evaluated according to predisposing factors, as these subgroups differ by incidence rate, clinical course, and prognosis. The three most significant groups at risk of PML are patients with hematological malignancies m...
Orphan Drugs In Development For The Treatment Of Friedreich's Ataxia: Focus On Omaveloxolone [0.03%]
治疗弗里德赖希共济失调在研孤儿药：奥马捷洛龙值得关注
Shaila D Ghanekar,Wai Wai Miller,Colin J Meyer et al.
Shaila D Ghanekar et al.
Friedreich's Ataxia (FRDA) is a devastating and progressive ataxia, marked by mitochondrial dysfunction and oxidative stress. Nrf2 activators such as omaveloxolone (Omav) modulate antioxidative mechanisms, and thus may be viable therapeutic...
Clinical and research applications of neuromuscular ultrasound in amyotrophic lateral sclerosis [0.03%]
神经肌肉超声在肌萎缩侧索硬化症临床和研究中的应用
Stephanie L Barnes,Neil G Simon
Stephanie L Barnes
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by dysfunction at multiple levels of the neuraxis. It remains a clinical diagnosis without a definitive diagnostic investigation. Electrodiagnosti...
Effect of the micro-immunotherapy medicine 2LPARK® on rat primary dopaminergic neurons after 6-OHDA injury: oxidative stress and survival evaluation in an in vitro model of Parkinson's disease [0.03%]
微免疫治疗药物2LPARK对6-羟基多巴胺损伤后原代多巴胺能神经元的氧化应激和生存评价：体外帕金森病模型中的作用效果
Nicoletta L Lilli,Delphine Révy,Sandra Robelet et al.
Nicoletta L Lilli et al.
Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by motor impairments and resulting from progressive degenerative loss of midbrain dopaminergic (DAergic) neurons in the substantia nigra. A...