Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA [0.03%]
脊髓损伤和多发性硬化症的神经源性膀胱过度活动症的肉毒杆菌毒素治疗研究进展
K D Ethans,A R Casey,R J Bard et al.
K D Ethans et al.
People with neurogenic overactive bladder from either multiple sclerosis or spinal cord injury often suffer significant morbidity and decreased quality of life. Here we review the pathophysiology of neurogenic overactive bladder and the imp...
Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms [0.03%]
多发性硬化症的神经退行性疾病涉及多种致病机制
Michael C Levin,Joshua N Douglas,Lindsay Meyers et al.
Michael C Levin et al.
Multiple sclerosis (MS) is a complex autoimmune disease that impairs the central nervous system (CNS). The neurological disability and clinical course of the disease is highly variable and unpredictable from one patient to another. The caus...
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation [0.03%]
轴浆运输与神经退行性疾病：囊泡-动力蛋白复合物的形成及其调节机制
Eric N Anderson,Joseph A White,Shermali Gunawardena
Eric N Anderson
The process of axonal transport serves to move components over very long distances on microtubule tracks in order to maintain neuronal viability. Molecular motors - kinesin and dynein - are essential for the movement of neuronal cargoes alo...
Poststroke cognitive impairment and dementia: prevalence, diagnosis, and treatment [0.03%]
卒中后认知障碍和痴呆：流行病学、诊断与治疗
Susanna Melkas,Hanna Jokinen,Marja Hietanen et al.
Susanna Melkas et al.
Three aspects of poststroke cognitive impairment and dementia are discussed in this review: prevalence; diagnosis; and treatment. The aim is to increase awareness of poststroke cognitive impairment in order to further stimulate strategies t...
Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease [0.03%]
β-分泌酶抑制剂在阿尔茨海默病治疗中的应用分析
Genevieve Evin,Adel Barakat
Genevieve Evin
Alzheimer's disease (AD) is the major cause of dementia in the elderly and an unmet clinical challenge. A variety of therapies that are currently under development are directed to the amyloid cascade. Indeed, the accumulation and toxicity o...
Re-Evaluating the Use of IFN-β and Relapsing Multiple Sclerosis: Safety, Efficacy and Place in Therapy [0.03%]
干扰素β与复发性多发性硬化症：安全性、疗效和治疗地位的再评价
Carolyn H Goldschmidt,Le H Hua
Carolyn H Goldschmidt
The advent of interferon therapy for the treatment of multiple sclerosis (MS) was a massive advancement in the field and changed the course of the disease. While the exact mechanism of interferon therapy in MS is unknown, disease control is...
Dysphagia In Multiple Sclerosis Patients: Diagnostic And Evaluation Strategies [0.03%]
多发性硬化患者吞咽困难的诊断及评估策略
Noureddin Nakhostin Ansari,Maryam Tarameshlu,Leila Ghelichi
Noureddin Nakhostin Ansari
Dysphagia after multiple sclerosis (MS) is a common disabling symptom which can lead to serious complications. Regular screening and assessment of dysphagia in patients with MS are important. Using valid and reliable instruments to measure ...
Hamidreza Famitafreshi,Morteza Karimian
Hamidreza Famitafreshi
Neurologic and neuropsychiatric diseases are associated with great morbidity and mortality. Prostaglandins (PGs) are formed by sequential oxygenation of arachidonic acid in physiologic and pathologic conditions. For the production of PGs cy...
Jill Rasmussen,Haya Langerman
Jill Rasmussen
Alzheimer's disease is the leading cause of dementia. However, neither Alzheimer's disease nor Alzheimer's dementia are an inevitable consequence of aging. This review provides an overview of the issues involved in a diagnosis of Alzheimer'...
Marge Kartau,Jussi Ot Sipilä,Eeva Auvinen et al.
Marge Kartau et al.
Cases of PML should be evaluated according to predisposing factors, as these subgroups differ by incidence rate, clinical course, and prognosis. The three most significant groups at risk of PML are patients with hematological malignancies m...