Spermidine in Alzheimer's Disease: Evidence from Animal Models and Human Studies [0.03%]
spermidine在阿尔茨海默病中的作用：来自动物模型和人类研究的证据
Francesco Angelucci,Jiří Cerman,Jana Amlerova et al.
Francesco Angelucci et al.
Spermidine is a naturally occurring polyamine involved in multiple cellular processes, including growth regulation, protein translation, and autophagy. Increasing attention has been devoted to its potential neuroprotective effects, particul...
Marked Clinical Improvement in Parkinson's Disease Following Double-Filtration Apheresis: A Case Report [0.03%]
血浆置换治疗帕金森病1例报告
Harald Burgard
Harald Burgard
Parkinson's disease (PD) is the fastest growing progressive neurological disorder globally, characterized by motor symptoms such as bradykinesia, rigidity, resting tremor as well as a wide range of non-motor manifestations. Here, we report ...
(Z)-Endoxifen as a Potential Modulator of Utrophin Pathways in Duchenne Muscular Dystrophy: A Mechanistic and Transcriptomic Perspective [0.03%]
作为杜氏肌营养不良上游硫蛋白通路调节剂的(扎)-恩托菲넴力机制和转录组学视角
H Lawrence Remmel,Sandra S Hammer,Scott M Blackburn et al.
H Lawrence Remmel et al.
Duchenne muscular dystrophy (DMD) is a fatal X-linked neuromuscular disorder caused by mutations in the dystrophin gene, leading to sarcolemmal instability, chronic calcium overload, mitochondrial dysfunction, inflammation, and fibrosis. Th...
Agreement and Comparative Performance of Cognitive Testing, Visual MRI Rating, and Automated Brain Morphometry in Older Adults with Suspected Dementia in Uganda [0.03%]
乌干达疑似痴呆老年人中认知测试、视觉MRI评分和自动化脑形态测量的符合性和比较性能
Rita Nassanga,Mark Kaddumukasa,Stephen E Jones et al.
Rita Nassanga et al.
Background: Dementia diagnosis in sub-Saharan Africa is constrained by limited access to specialist neuroimaging interpretation and reduced specificity of brief cognitive tools in low-literacy populations. We evaluated th...
The Gut-Brain Axis in Alzheimer's: From Microbiota Genetics to Stigmasterol's Neuroprotection Mechanism [0.03%]
肠-脑轴在阿尔茨海默病中的作用：从肠道微生物组遗传学到植物固醇的神经保护机制
Tunan Ding,Junlei Chen,Yunsheng Xiang et al.
Tunan Ding et al.
Objective: This study aimed to identify novel therapeutic targets for Alzheimer's disease (AD) by investigating the role of the intestinal flora (IF) via the gut-brain axis, and to predict a potential natural compound for...
Effectiveness of Siponimod with Up to 2 Years of Treatment in a Real-World Setting in People with SPMS: Analysis from the Novartis Global Managed Access Program [0.03%]
辛普尼莫德在现实环境中治疗继发进展型多发性硬化症长达两年的疗效：来自诺华全球管理准入项目的分析研究
Antonio Carotenuto,Dimitris Naoumis,Vincenzo Brescia Morra et al.
Antonio Carotenuto et al.
Background: Limited real-world data exist on the effectiveness of siponimod in people living with secondary progressive multiple sclerosis (plwSPMS). Obje...
Advancements in Therapy for Alzheimer's Disease Based on the Cerebral Lymphatic System [0.03%]
基于脑淋巴系统的阿尔茨海默病治疗进展
Feiyue Mi,Li Ren,Dongfeng Pan et al.
Feiyue Mi et al.
Background: Conventional therapeutic interventions for Alzheimer's disease (AD) are limited by multiple drawbacks, including anticholinesterase inhibitors, glutamate receptor antagonists, intestinal flora regulators and A...
Emodin, a Phytotherapeutic Anthraquinone, Potently Attenuates Synaptic Redox Pathology in Aged Rats [0.03%]
植物疗法蒽醌ematin强力减轻老年大鼠突触红氧化病理损伤
Priyanka Saha,Faraz Ahmad
Priyanka Saha
Background: Aging is associated with increased oxidative stress, which leads to synaptic vulnerability and psychiatric and cognitive deficits. Maintaining redox homeostasis is crucial for synaptic health. However, age-rel...
Genetic Spectrum and Phenotypic Variability in Chinese Patients with Multisystem Proteinopathy and Related Disorders [0.03%]
中国多系统蛋白病及相关障碍的遗传谱系及表型变异
Xingyu Xia,Xi Chen,Yiming Sun et al.
Xingyu Xia et al.
Objective: Multisystem proteinopathy (MSP) is a pleiotropic group of disorders initially presenting as inclusion body myopathy (IBM), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and/or Paget diseas...
Proteomic Identification of ALDOA as a Pathogenic TDP-43 Interaction Partner in ALS [0.03%]
ALS中TDP-43致病性相互作用蛋白ALDOA的蛋白质组学鉴定
Kaixin Yan,Jinfeng Deng,Yuxuan Yong et al.
Kaixin Yan et al.
Objective: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons, and its pathogenesis has not been fully elucidated. TAR DNA-binding protein 43 (TDP-43), as...