A Case Report and Literature Review of Charcot-Marie-Tooth Disease Type 2F in a Family [0.03%]
一家系Charcot-Marie-Tooth病Ⅱ型F病例报告及文献复习
Yanli Lei,Li Cheng,Weijing Zhao et al.
Yanli Lei et al.
Objective: To report the clinical and genetic characteristics of a rare Charcot-Marie-Tooth disease type 2F (CMT2F) pedigree, and to explore the phenotypic diversity and diagnostic essentials of the mutation in combinatio...
Symptom Networks and Associations with Quality of Life in Patients with Early to Mid-Stage Parkinson's Disease: A Network Analysis [0.03%]
帕金森病早期至中期患者的症状网络及其与生活质量的关联：一项网络分析研究
Qiu Deng,Yaoling Duan,Zhengting Yang et al.
Qiu Deng et al.
Purpose: The symptoms of patients with early to mid-stage Parkinson's disease (PD) are closely associated with their quality of life. However, few studies have explored the relationship between symptoms and quality of lif...
Amyotrophic Lateral Sclerosis Masquerading as Multiple System Atrophy with Parkinsonism and Anxiety as Initial Manifestations [0.03%]
以帕金森病和焦虑为初始表现的肌萎缩侧索硬化症一例
Haiyan Tang,Jianping Yao,Zhuang Wang
Haiyan Tang
Introduction: Amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA) are both neurodegenerative disorders. While ALS may present with clinical features resembling Parkinsonism, there have been no definitive...
TP73-AS1 Regulates MPP+-Induced Cell Inflammation and Apoptosis in SH-SY5Y Cells [0.03%]
TP73-AS1调节MPP+诱导的SH-SY5Y细胞炎症和凋亡
Xue Zhang,Li Xue,Haiyan Li et al.
Xue Zhang et al.
Background: The aim was to investigate the potential role of TP73-AS1 in the pathogenesis of Parkinson's disease. Methods: Peripheral b...
Nitish M Khindri,Mary C Maj
Nitish M Khindri
Parkinson's disease is a neurodegenerative disorder that leads to neuronal loss. Though a variety of genetic and environmental factors may be involved in the etiology, the presentation of the disorder is very similar. Trace minerals such as...
Based on the Dual Pathway of Interaction-Mediated NF-κB in Cell Apoptosis and Immune Inflammation to Study the Effect of Danzhi Xiaoyao Powder on the Learning and Cognitive Ability of AD Model Rats [0.03%]
基于NF-κB交互作用的双信号通路探讨丹栀逍遥散对AD模型大鼠学习认知能力的影响机制研究
Hu-Ping Wang,Ming-Cheng Li,Jiao Yang et al.
Hu-Ping Wang et al.
Background: Apoptosis and immune inflammation play important roles in the pathological process of Alzheimer's disease (AD), but their specific pathogenesis is still unclear. Therefore, this article focuses on exploring th...
Gene Editing for Duchenne Muscular Dystrophy: From Experimental Models to Emerging Therapies [0.03%]
杜氏肌营养不良的基因编辑治疗：从实验模型到新兴疗法
Umme Sabrina Haque,Toshifumi Yokota
Umme Sabrina Haque
The CRISPR system has emerged as a ground-breaking gene-editing tool, offering promising therapeutic potential for Duchenne muscular dystrophy (DMD), a severe genetic disorder affecting approximately 1 in 5000 male births globally. DMD is c...
A Hypothesized Therapeutic Role of (Z)-Endoxifen in Duchenne Muscular Dystrophy (DMD) [0.03%]
(Z)-Endoxifen在杜氏肌营养不良症(DMD)中潜在的治疗作用假设
H Lawrence Remmel,Sandra S Hammer,Laurence A Neff et al.
H Lawrence Remmel et al.
Duchenne Muscular Dystrophy (DMD) is an inherited, X-linked disorder that is progressive, debilitating, and ultimately fatal. The current therapeutic landscape offers no cures, but does include palliative treatments that delay disease progr...
Cold Inducible RNA-Binding Protein Promotes the Development of Alzheimer's Disease Partly by Inhibition of uPA in Astrocytes [0.03%]
冷诱导RNA结合蛋白通过抑制星形胶质细胞中的uPA促进阿尔茨海默病的发展
Ze Li,Jing Peng Liu,Feng Hua Yao et al.
Ze Li et al.
Background: Cold inducible RNA-binding protein (CIRP) is an important danger-associated molecular pattern involved in tissue-specific and systemic inflammation related to inflammation and Alzheimer's disease (AD). However...
Integrated Transcriptome Analysis Reveals Molecular Subtypes and ceRNA Networks in Multiple Sclerosis [0.03%]
整合转录组分析揭示多发性硬化分子亚型和ceRNA网络
Caili Ji,Li Ding,Fumin Jia et al.
Caili Ji et al.
Aim: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS). While extensively studied, its molecular subtypes and mechanisms remain poorly understood, hindering the identificat...