Use of BTK Inhibitors in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): A Practical Guidance [0.03%]
慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(BTK抑制剂的使用：实际指导建议
Frédérique St-Pierre,Shuo Ma
Frédérique St-Pierre
The treatment landscape of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has changed significantly since the development of oral Bruton's tyrosine kinase (BTK) inhibitors. While chemoimmunotherapy was previously the stan...
Asparaginase in the Treatment of Acute Lymphoblastic Leukemia in Adults: Current Evidence and Place in Therapy [0.03%]
尿苷在成人急性淋巴细胞白血病治疗中的证据和地位分析
Krishna R Juluri,Chloe Siu,Ryan D Cassaday
Krishna R Juluri
Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy resulting in the production of abnormal lymphoid precursor cells. Occurring in B-cell and T-cell subtypes, ALL is more common in children, comprising nearly 30% of pediatri...
Intravascular Large B Cell Lymphoma with CNS Involvement Successfully Treated with High-Dose Methotrexate and High-Dose Ara-C Based CNS-Directed Chemoimmunotherapy Alternating with Anthracycline Based Chemoimmunotherapy [0.03%]
以高剂量甲氨蝶呤和阿糖胞苷中枢神经定向化疗免疫治疗联合蒽环类为基础的化疗免疫交替治疗成功治愈中枢神经系统受侵的大B细胞淋巴瘤1例
Jing Wang,Muhamad Alhaj Moustafa,Justin J Kuhlman et al.
Jing Wang et al.
Intravascular large B cell lymphoma (IVL) is a rare subtype of diffuse large B cell lymphoma confined to small blood vessels with a predilection for CNS involvement. The prognosis of IVL with CNS involvement (CNS-IVL) is extremely poor. The...
Ayenew Berhan,Biruk Bayleyegn,Zegeye Getaneh
Ayenew Berhan
Lymphoma is one of the hematologic malignancies that occur at a higher rate in human immunodeficiency virus-infected individuals. It is one of the most frequent neoplastic causes of death in those individuals. Non-Hodgkin's lymphoma and Hod...
Long-Term Survival with Ibrutinib Therapy in Elderly Patients with Newly Diagnosed Primary Central Nervous System Lymphoma [0.03%]
伊布替尼治疗新诊断老年原发中枢神经系统淋巴瘤患者的长期生存研究
Justin J Kuhlman,Muhamad Alhaj Moustafa,Liuyan Jiang et al.
Justin J Kuhlman et al.
Primary central nervous system lymphoma (PCNSL) carries a dismal prognosis in elderly patients above 70 years of age with a median overall survival of 6 months. Novel therapeutic agents are urgently needed to improve survival outcomes in th...
Neuropsychiatric Manifestations of Lymphoma-Associated Cerebral Glucose Hypometabolism Can Be Reversed by Intensive Glucose Supplementation [0.03%]
淋巴瘤相关脑葡萄糖低代谢的精神神经表现可通过强化葡萄糖补充逆转
Adam M Kase,Catherine Bullock,Ricardo Parrondo et al.
Adam M Kase et al.
Cerebral glucose hypometabolism (CGHM) is characterized by diffuse or focal reduction in uptake of glucose by the brain as determined on a FDG PET-CT. We report a case of lymphoma-associated cerebral glucose hypometabolism (LA-CGHM) in a pa...
How I Manage Patients with Chronic Myeloid Leukemia (CML): Perspectives from Clinical Practice [0.03%]
我如何管理慢性髓系 leukemia(CML)患者——临床实践观点
Guru Subramanian Guru Murthy
Guru Subramanian Guru Murthy
The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched...
Clinical Value of Measurable Residual Disease in Acute Lymphoblastic Leukemia [0.03%]
急性淋巴细胞白血病中测量残留病灶的临床价值
Kyaw Hein,Nicholas Short,Elias Jabbour et al.
Kyaw Hein et al.
Measurable (minimal) residual disease (MRD) status in acute lymphoblastic leukemia (ALL) has largely superseded the importance of traditional risk factors for ALL, such as baseline white blood cell count, cytogenetics, and immunophenotype, ...
Successful Non-Transplant Treatment of Double Hit Richter Transformation with Long-Term Remission [0.03%]
双重打击Richter转变的长期缓解的非移植成功治疗
Karan Seegobin,Muhamad Alhaj Moustafa,Liuyan Jiang et al.
Karan Seegobin et al.
Richter transformation (RT) is defined as the transformation of chronic lymphocytic leukemia (CLL) to a high-grade B cell lymphoma. It usually carries a dismal prognosis and represents an unmet need for novel therapeutic interventions. We r...
Recent Advances in the Management of Patients with Relapsed/Refractory Follicular Lymphoma [0.03%]
复发/难治滤泡性淋巴瘤患者的治疗新进展
Georgios Pongas,Bruce Cheson
Georgios Pongas
Advanced follicular lymphoma (FL) often relapses after front-line chemoimmunotherapy, and many patients will eventually require subsequent therapy. In 2021, two new therapies were granted approval by the Food and Drug Administration (FDA), ...