Construction and Validation of an N7-Methylguanosine-Related Prognostic Model for Acute Myeloid Leukemia [0.03%]
Lina Wang,Ming Li,Yaming Xi
Lina Wang
Purpose: Increasing evidence suggests the involvement of N7-methylguanosine (m7G) in cancer biology. However, its role in acute myeloid leukemia (AML) remains unclear. Herein, bioinformatics approaches were used to obtain...
Health Disparities in Acute Myeloid Leukemia Patients Undergoing Treatment with Tyrosine Kinase Inhibitor (TKI) Therapy Targeting FLT3, IDH1, or IDH2 [0.03%]
Manuel R Espinoza-Gutarra,Brooke A Jarrett,Xiaoliang Wang et al.
Manuel R Espinoza-Gutarra et al.
Acute Myeloid Leukemia (AML) is a common hematologic neoplasm in adults and usually carries a grim prognosis. Therapy has traditionally consisted of intensive chemotherapy; however, recent advances have led to the development of Tyrosine Ki...
Association Between Petroleum Compounds Exposure and Risk of Childhood Leukemia: A Systematic Review [0.03%]
儿童白血病与石油化合物暴露关系的系统评价
Hossam Mohamed Hassan Soliman,Wesal Youssef Hassan,Marwa Mostafa et al.
Hossam Mohamed Hassan Soliman et al.
Childhood leukemia remains a critical public health concern, necessitating comprehensive evaluations of environmental risk factors. This systematic review aims to evaluate the epidemiological evidence regarding the relationship between comb...
Global Patterns, Temporal Trends, and Potential Non-Infectious Risk Factors for Burkitt Lymphoma from 1990 to 2021 [0.03%]
1990至2021年Burkitt淋巴瘤的全球模式、时间趋势及其潜在非传染性危险因素
Shi-Kai Jin,Jun-Ting Lyu,Zi-Yu Feng et al.
Shi-Kai Jin et al.
Background: The heterogeneity in the health burden and non-infectious risk factors of Burkitt lymphoma (BL) across sex, age, and geographic distribution remain inadequately understood. ...
Expression and Clinical Significance of BCL2 Interacting Protein 3 Like (BNIP3L) in Serum of Patients with MM [0.03%]
MM患者血清BNIP3L表达及其临床意义
Yanyu Nong,Zengyi Xiong,Qicai Wang et al.
Yanyu Nong et al.
Background: BNIP3L regulates mitophagy and apoptosis, and its dysregulation is closely linked to the development and progression of cancers. Studies have shown that BNIP3L is valuable for assessing tumor progression and p...
LRG1 Drives AML Progression by Disrupting Myeloid Progenitor Regulation [0.03%]
LRG1通过干扰粒系祖细胞调控促进急性髓系白血病进展
Rongxia Guo,Peng Wu,Shuxin Yao et al.
Rongxia Guo et al.
Background: Acute myeloid leukemia (AML) remains clinically challenging due to its molecular heterogeneity and poor outcomes, highlighting the urgent need for novel biomarkers and therapeutic targets. ...
Alantolactone Inhibits Double Expression Lymphoma via Dual-Targeted Glycogen Synthase Kinase 3 Beta and B-Cell Lymphoma2 [0.03%]
阿尔托龙通过双重靶向糖原合酶激酶3β和B细胞淋巴瘤2抑制双表达淋巴瘤
Jianhua Chen,Qing Liao,Sha Yang et al.
Jianhua Chen et al.
Background: Dual-expression lymphoma (DEL) is an aggressive subtype with concurrent MYC and BCL2 overexpression. This disease exhibits a poor prognosis and responds poorly to standard R-CHOP therapy,highlighting the urgen...
Phase II Trial of an Orelabrutinib-Based Combination Therapy in Newly Diagnosed Primary Central Nervous System Lymphoma [0.03%]
奥雷布替尼联合方案治疗新诊断原发中枢神经系统淋巴瘤II期临床研究
Yajing Zhao,Xinguang Liu,Qiang He et al.
Yajing Zhao et al.
Purpose: Primary central nervous system lymphoma (PCNSL) is a rare, yet highly aggressive non-Hodgkin lymphoma confined to the central nervous system (CNS). High-dose methotrexate (HD-MTX) remains the baseline chemotherap...
Venetoclax Plus Blinatumoma as First Line Therapy for Newly Diagnosed Ph-Negative B-Cell Acute Lymphoblastic Leukemia [0.03%]
维奈克拉联合博纳吐单抗作为新诊断Ph阴性B细胞急性淋巴细胞白血病初治方案
Yutian Lei,Xiaoli Zhao,Huijun Huang et al.
Yutian Lei et al.
Purpose: This study evaluated the efficacy and safety of a 14-day blinatumomab-venetoclax (BV) regimen as induction therapy for newly diagnosed Ph-negative B-cell acute lymphoblastic leukemia (B-ALL), focusing on rapid re...
The Ongoing Challenges of Managing Cytopenic Myelofibrosis in 2025: The Emergence of Non-JAK Inhibitor Therapies [0.03%]
2025年环孢素样贫血性骨髓纤维化的管理面临的挑战：非JAK抑制剂治疗的出现
Samuel B Reynolds,Rami Komrokji,Andrew T Kuykendall
Samuel B Reynolds
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that is felt to arise from somatic mutations with hematopoietic stem and progenitor cells (HSPC's), leading to the development of atypical megakaryocytic hyperplasia. Associated d...