Successful Anatomy Adapted Therapeutic Management and Genetic Profiling of Primary Pituitary Diffuse Large B-Cell Lymphoma [0.03%]
原发垂体弥漫大B细胞淋巴瘤的治疗适应解剖学和基因特征谱分析成功经验总结
ErinMarie O Kimbrough,Vivek Gupta,Liuyan Jiang et al.
ErinMarie O Kimbrough et al.
Primary pituitary diffuse large B-cell lymphoma (PPL) has been regarded as a subtype of primary central nervous system lymphoma (PCNSL); however, the pituitary gland is located outside the blood brain barrier (BBB) with neural and vascular ...
Tesfaye Gessese,Fikir Asrie,Zewudu Mulatie
Tesfaye Gessese
Human immunodeficiency virus infection is related with an increased risk of hematological malignancy principally, non-Hodgkin lymphoma. Most non-Hodgkin lymphomas are acquired immunodeficiency syndrome defining and constitute greater than 5...
Naji Bou Zeid,Victor Yazbeck
Naji Bou Zeid
Phosphatidylinositol 3-kinases (PI3Ks) are a family of intracellular signal transducer enzymes that can attach a phosphate group to the 3'-hydroxyl of the inositol moiety of membrane-embedded phosphatidylinositol (PI). PI3Ks have been shown...
FLT3 Inhibitors as Maintenance Therapy after Allogeneic Stem-Cell Transplantation [0.03%]
异基因干细胞移植后 FLT3 抑制剂作为维持治疗
Amanda Blackmon,Ibrahim Aldoss,Brian J Ball
Amanda Blackmon
Mutations in the FLT3 gene are associated with poor prognosis in patients with AML, even after consolidation with allogeneic hematopoietic cell transplantation (alloHCT) in first remission. Treatment failure in FLT3-mutated AML is largely d...
CAR T-Cell Therapy for Patients with Multiple Myeloma: Current Evidence and Challenges [0.03%]
多发性骨髓瘤CAR-T细胞疗法现状及挑战
Matthew J Rendo,Jacinth J Joseph,Liem Minh Phan et al.
Matthew J Rendo et al.
The therapeutic landscape of multiple myeloma (MM) has benefited from an emergence of novel therapies over the last decade. By inducing T-cell kill of target cancer cells, chimeric antigen receptor (CAR) T-cell therapies have improved outco...
Differential Diagnosis of Waldenström's Macroglobulinemia and Early Management: Perspectives from Clinical Practice [0.03%]
Waldenström巨球蛋白血症的鉴别诊断及早期处理：临床实践观点
Shashank Cingam,Surbhi Sidana
Shashank Cingam
Waldenström's Macroglobulinemia (WM) is a clonal B-lymphocyte neoplasm characterized by the presence of IgM monoclonal protein and ≥10% bone marrow involvement with lymphoplasmacytic cells. Several mature B-cell and plasma cell disorders ...
A Promising Future for Precision Epigenetic Therapy for Follicular and Diffuse Large B-Cell Lymphoma? [0.03%]
精确表观遗传治疗滤泡性和弥漫性大B细胞淋巴瘤的前景如何？
Clement Chung
Clement Chung
Epigenetic mechanisms such as DNA hypermethylation or histone deacetylation normally silence gene expression that regulates numerous cellular activities. Germinal center-derived lymphomas such as follicular lymphoma (FL) and diffuse large B...
Use of BTK Inhibitors in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): A Practical Guidance [0.03%]
慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(BTK抑制剂的使用：实际指导建议
Frédérique St-Pierre,Shuo Ma
Frédérique St-Pierre
The treatment landscape of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has changed significantly since the development of oral Bruton's tyrosine kinase (BTK) inhibitors. While chemoimmunotherapy was previously the stan...
Asparaginase in the Treatment of Acute Lymphoblastic Leukemia in Adults: Current Evidence and Place in Therapy [0.03%]
尿苷在成人急性淋巴细胞白血病治疗中的证据和地位分析
Krishna R Juluri,Chloe Siu,Ryan D Cassaday
Krishna R Juluri
Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy resulting in the production of abnormal lymphoid precursor cells. Occurring in B-cell and T-cell subtypes, ALL is more common in children, comprising nearly 30% of pediatri...
Intravascular Large B Cell Lymphoma with CNS Involvement Successfully Treated with High-Dose Methotrexate and High-Dose Ara-C Based CNS-Directed Chemoimmunotherapy Alternating with Anthracycline Based Chemoimmunotherapy [0.03%]
以高剂量甲氨蝶呤和阿糖胞苷中枢神经定向化疗免疫治疗联合蒽环类为基础的化疗免疫交替治疗成功治愈中枢神经系统受侵的大B细胞淋巴瘤1例
Jing Wang,Muhamad Alhaj Moustafa,Justin J Kuhlman et al.
Jing Wang et al.
Intravascular large B cell lymphoma (IVL) is a rare subtype of diffuse large B cell lymphoma confined to small blood vessels with a predilection for CNS involvement. The prognosis of IVL with CNS involvement (CNS-IVL) is extremely poor. The...