A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights [0.03%]
多发性骨髓瘤单核细胞驱动的预后模型：多组学和机器学习见解
Linzhi Xie,Meng Gao,Shiming Tan et al.
Linzhi Xie et al.
Background: Multiple myeloma (MM) is a haematological malignancy, driven by complex interactions between tumor and immune cells. Nevertheless, the overall pattern of immune cells and MM pathogenesis within the bone marrow...
An Updated Indirect Comparison of Elranatamab Versus a Real-World External Control Arm in Triple-Class Refractory Multiple Myeloma [0.03%]
关于Elranatamab versus三重治疗难治性多发性骨髓瘤的间接比较的更新研究
Luciano J Costa,Thomas W LeBlanc,Hans Tesch et al.
Luciano J Costa et al.
Purpose: Elranatamab is a BCMAxCD3 bispecific antibody approved for the treatment of relapsed/refractory multiple myeloma (RRMM). The registrational Phase 2 MagnetisMM-3 (NCT04649359) trial was single-armed; the aim of th...
Ahmad Al-Jarrad,Samhar Samer Alouch,Yogesh Chawla et al.
Ahmad Al-Jarrad et al.
T-cell engagers (TCEs) are engineered to bind both the CD3 subunit on T-cells and specific antigens on tumor cells, triggering T-cell activation and tumor cell lysis. TCEs targeting B-cell maturation antigen (BCMA) and G-protein-coupled rec...
The Antibody Drug Conjugate, Belantamab-Mafodotin, in the Treatment of Multiple Myeloma: A Comprehensive Review [0.03%]
Belantamab-mafodotin治疗多发性骨髓瘤的疗效和安全性：综述分析
Adrian Alfonso Almodovar Diaz,Samhar Samer Alouch,Yogesh Chawla et al.
Adrian Alfonso Almodovar Diaz et al.
Despite recent advancements in treatments, including proteasome inhibitors, immunomodulators, and anti-CD38 monoclonal antibodies, multiple myeloma (MM) remains mostly incurable with patients frequently experiencing disease relapses due to ...
Highly Curative Treatment of High-Risk Acute Promyelocytic Leukemia: Induction and Consolidation with ATRA+ATO+anthracyclines and Maintenance with ATRA+RIF [0.03%]
高危急性早幼粒细胞白血病高治愈率的诱导及consolidation方案：ATRA+ATO+蒽环类，维持治疗期为ATRA+RIF
Dan Liu,Juan Tong,Erling Chen et al.
Dan Liu et al.
Background: The aim of the study was to evaluate the efficacy and safety of induction and consolidation with all-trans retinoic acid (ATRA) +arsenic trioxide (ATO) +anthracyclines and maintenance with ATRA +Realgar-Indigo...
Albumin-to-Globulin Ratio Combined with Neutrophil-to-Lymphocyte Ratio as a Prognostic Predictor in Multiple Myeloma with Renal Impairment [0.03%]
肾损害患者的多发性骨髓瘤中，白蛋白与球蛋白比值联合中性粒细胞与淋巴细胞比值的预后预测作用
Yingzi Zhang,Xiajuan Yao,Yaoquan Zhang et al.
Yingzi Zhang et al.
Background: The albumin-to-globulin ratio (AGR) and neutrophil-to-lymphocyte ratio (NLR) have been recently regarded as promising prognostic factors in various malignancies. The present study investigated the prognostic v...
Identification of a Prognostic Model Based on NK Cell-Related Genes in Multiple Myeloma Using Single-Cell and Transcriptomic Data Analysis [0.03%]
基于单细胞和转录组数据分析识别多发性骨髓瘤中与NK细胞相关基因的预后模型
Nan Mei,Sha Gong,Lizhao Wang et al.
Nan Mei et al.
Background: Multiple myeloma (MM), an incurable plasma cell malignancy. The significance of the relationship between natural killer (NK) cell-related genes and clinical factors in MM remains unclear. ...
AC024896.1/miR-363-3p Axis Regulates the Malignant Progression of Acute Myeloid Leukemia by Cuproptosis-Related Gene MYO1B [0.03%]
AC024896.1/miR-363-3p轴通过铜死亡相关基因MYO1B调控急性髓系白血病恶性进展
Jie Zhang,Yuhuan Zheng,Hongjuan Liu et al.
Jie Zhang et al.
Background: Acute myeloid leukemia (AML) is a hematological malignancy with poor patient prognosis. Cuprotosis is a newly discovered cell death that regulates the proliferation and progression of tumor cells. Long non-cod...
Francesco Malfona,Anna Maria Testi,Sabina Chiaretti et al.
Francesco Malfona et al.
Despite excellent results in frontline therapy, particularly in pediatric age, refractory Burkitt lymphoma still remains a therapeutic challenge, with dismal outcome. The prognosis is very poor, ranging from less than 10% to 30-40%, with lo...
Andrea Duminuco,Patrick Harrington,Claire Harrison et al.
Andrea Duminuco et al.
Polycythemia vera (PV) is a subtype of myeloproliferative neoplasms characterized by impaired quality of life and severe complications. Despite the increasingly in-depth knowledge of this condition, it necessitates a multifaceted management...