Elinor B Lindskog,Yvonne Wettergren,Elisabeth Odin et al.
Elinor B Lindskog et al.
Background: The thymidine phosphorylase (TP) enzyme has several tumor-promoting functions. The aim of this study was to explore TP gene expression in relation to clinical and histopathological data obtained from patients ...
Claribel P L Simmons,Nicholas Macleod,Barry J A Laird
Claribel P L Simmons
Lung cancer is the most common cancer in the world and pain is its most common symptom. Pain can be brought about by several different causes including local effects of the tumor, regional or distant spread of the tumor, or from anti-cancer...
A De Novo Germline APC Mutation (3927del5) in a Patient with Familial Adenomatous Polyposis: Case Report and Literature Review [0.03%]
家族性腺瘤性息肉病患者的APC基因新发种系突变(3927del5)：病例报告与文献复习
Simon B Zeichner,Naveen Raj,Mike Cusnir et al.
Simon B Zeichner et al.
Introduction: Characterized by the development of hundreds to thousands of colonic adenomas, classic familial adenomatous polyposis (FAP) is one of the most common hereditary syndromes associated with an increased risk of...
Chitradeep De,Jaya Phookan,Valay Parikh et al.
Chitradeep De et al.
Case report: A 75-yr-old gentleman, with a past medical history of diabetes mellitus and Acute Myeloid Leukemia presented to our emergency department with a chief complaint of exertional dyspnea and chest pain. A week pri...
Safety and efficacy of pralatrexate in the management of relapsed or refractory peripheral T-cell lymphoma [0.03%]
派罗特雷克斯治疗复发或难治外周T细胞淋巴瘤的安全性和疗效评估
Annabelle L Rodd,Katherine Ververis,Tom C Karagiannis
Annabelle L Rodd
Peripheral T-cell lymphoma (PTCL) represents a relatively rare group of heterogeneous non-Hodgkin lymphomas, with generally poor prognosis. Historically, there has been a lack of consensus regarding appropriate therapeutic measures for the ...
Treatment-induced bone loss and fractures in cancer patients undergoing hormone ablation therapy: efficacy and safety of denosumab [0.03%]
治疗去势疗法癌症患者的治疗性骨丢失和骨折：地诺单抗的疗效及安全性研究
Allan Lipton,Matthew R Smith,Georgiana K Ellis et al.
Allan Lipton et al.
Hormone ablation therapy (HALT) for breast or prostate cancer accelerates the development of osteoporosis in both men and women by causing estrogen deficiency, which increases the risk for fracture by promoting bone resorption mediated by o...
Joanne M Jeter,Lee D Cranmer,Evan M Hersh
Joanne M Jeter
Immune augmentation with ipilimumab, an anti-CTLA-4 monoclonal antibody, has joined the ranks of approved immunologic agents for the treatment of metastatic melanoma. Phase III studies of ipilimumab in metastatic melanoma have demonstrated ...
Sosipatros A Boikos,Emmanuel S Antonarakis
Sosipatros A Boikos
In the United States, prostate cancer is the most frequent malignancy in men and ranks second in terms of mortality. Although recurrent or metastatic disease can be managed initially with androgen ablation, most patients eventually develop ...
The effectiveness of maintenance pharmacotherapies for non-small cell lung cancer [0.03%]
维持性药物治疗非小细胞肺癌的有效性
Myung-Ju Ahn,Jong-Mu Sun,Jin Sock Ahn et al.
Myung-Ju Ahn et al.
Although current recommendations for the treatment of advanced non-small cell lung cancer (NSCLC) include a maximum of six cycles of platinum-based combination therapy as a first-line approach, most patients experience progression within 3-...
Nils Degrauwe,Julie Ann Sosa,Sanziana Roman et al.
Nils Degrauwe et al.
Medullary thyroid cancer (MTC) represents an aggressive form of thyroid malignancy. Some may occur spontaneously or can be associated with Multiple Endocrine Neoplasia syndromes, or Familial Medullary Thyroid Cancer syndrome. In these patie...