C609T Polymorphism of NADPH Quinone Oxidoreductase 1 Correlates Clinical Hematological Toxicities in Lung Cancer Patients Treated with Amrubicin [0.03%]
NADPH喹啉氧化还原酶1的C609T多态性与接受氨柔比星治疗的肺癌患者的临床血液学毒性相关性研究
Misato Nagata,Tatsuo Kimura,Tomohiro Suzumura et al.
Misato Nagata et al.
Background: Amrubicin hydrochloride (AMR) is a key agent for lung cancer. NADPH quinone oxidoreductase 1 (NQO1) metabolizes the quinone structures contained in both amrubicin (AMR) and amrubicinol (AMR-OH). We hypothesize...
Multicenter Phase II Study of a New Effective S-1 and Irinotecan Combination Schedule in Patients with Unresectable Metastatic or Recurrent Colorectal Cancer [0.03%]
一项新的替加氟与伊立替康联合方案治疗不可切除转移性或复发性结直肠癌的Ⅱ期多中心临床研究
Yutaka Ogata,Takaho Tanaka,Yoshito Akagi et al.
Yutaka Ogata et al.
Introduction: This multicenter phase II study determined the efficacy and safety of new daily oral S-1 and weekly irinotecan (CPT-11) combination schedule in patients with previously untreated advanced or recurrent colore...
Juxtacortical clavicular chondrosarcoma: diagnostic dilemmas: case report and review of literature [0.03%]
与皮质相邻的锁骨软骨肉瘤：诊断难题：病例报告及文献回顾
E I Efremidou,A Oikonomou,E Pavlidou et al.
E I Efremidou et al.
Juxtacortical chondrosarcoma is a rare primary malignant cartilaginous tumor accounting for 0.2% of all bone tumors. Wide surgical resection is the treatment of choice for juxtacortical chondrosarcomas. Accurate preoperative diagnosis is im...
Safety and efficacy of cabazitaxel in the docetaxel-treated patients with hormone-refractory prostate cancer [0.03%]
卡巴他赛治疗多西他赛治疗过的前列腺癌患者的疗效和安全性研究
Fabien Calcagno,Thierry Nguyen,Erion Dobi et al.
Fabien Calcagno et al.
Prostate cancer (PC) is one of the most common cancers and is a leading cause of death. Its initial growth is dependent on androgens; most patients show an initial response to hormonal therapy but will experience disease progression when PC...
Takuya Araki,Hideaki Yashima,Kimihiro Shimizu et al.
Takuya Araki et al.
In the past decade, molecular-targeted drugs have been focused upon for the treatment of cancer. In 2002, gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor became available in Japan for the treatment of non-sma...
Clinical Significance of ALK-1 Gene Abnormalities in Diffuse Large Cell Lymphoma [0.03%]
ALK-1基因异常在弥漫性大B细胞淋巴瘤中的临床意义
L Korashy,H El-Zawahry,S Abdou et al.
L Korashy et al.
Objectives: To detect relative frequency of anaplastic lymphoma kinase (ALK-1) gene abnormality in diffuse large cell lymphoma (DLCL) using fluorescence in situ hybridization (FISH), and correlate its presence with clinic...
Safety and efficacy of sunitinib in patients with unresectable pancreatic neuroendocrine tumors [0.03%]
舒尼替尼治疗不可切除的胰腺神经内分泌肿瘤患者的疗效和安全性研究
Marcus W Wiedmann,Joachim Mössner
Marcus W Wiedmann
Pancreatic neuroendocrine tumors (PNETs) are becoming increasingly common, with the majority of patients presenting with either lymph node involvement or metastatic disease, thus requiring systemic therapy. Targeted therapy is a type of med...
An unusual instrumentation-related s1 radiculopathy in a patient treated for a primary vertebral (l3) lymphoma [0.03%]
一例原发椎体内淋巴瘤(L3)患者的特殊仪器相关性S1神经根病
Maurizio Iacoangeli,Alessandro Di Rienzo,Niccolò Nocchi et al.
Maurizio Iacoangeli et al.
Paravertebral titanium rod migration represents an unusual and potentially fatal complication of vertebral stabilization surgical procedures. This condition, which requires a prompt and rapid diagnosis, is often mistaken for other more comm...
J Quidde,D Arnold,A Stein
J Quidde
Large randomized trials demonstrated a benefit of adjuvant chemotherapy after resection of the primary colon cancer. It improves overall survival and reduces the risk of death, by 5% in UICC (Union Internationale Contre le Cancer) stage II ...
Efficacy and tolerability of pharmacotherapy options for the treatment of medullary thyroid cancer [0.03%]
治疗髓样甲状腺癌的药物治疗选择的有效性和耐受性
H A Deshpande,K Sheth,J A Sosa et al.
H A Deshpande et al.
Metastatic and unresectable medullary thyroid carcinoma (MTC) is often difficult to treat as it is relatively unresponsive to radiation and conventional chemotherapy. This emphasizes the importance of the development of targeted therapies f...