A novel germline BRCA1 mutation identified in a family with hereditary breast and ovarian cancer syndrome [0.03%]
家系遗传性乳腺癌和卵巢癌综合征中发现的新型BRCA1生殖细胞系突变
Yanmei Wu,Xiaodong Pan,Juan Dou et al.
Yanmei Wu et al.
Pathogenic germline mutations occurring in the BRCA1 (MIM:113705) and BRCA2 (MIM: 600185), which always result in truncated protein or nonsense-mediated mRNA decay, have been identified to increase the risk of hereditary breast, ovarian, pa...
Real-World Outcomes and Clinical Predictors of Immune Checkpoint Inhibitor Monotherapy in Advanced Lung Cancer [0.03%]
晚期肺癌症患者使用免疫检查点抑制剂单药治疗的临床预后因素和实际疗效分析
Shijia Zhang,Daniel F Pease,Amit A Kulkarni et al.
Shijia Zhang et al.
Background: Immune checkpoint inhibitors (ICIs) have changed the treatment paradigm of advanced-stage non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). The aim of this study was to evaluate the effecti...
Zhuangzhuang Shi,Mingzhi Zhang
Zhuangzhuang Shi
Lymphoid neoplasms encompass a heterogeneous group of malignancies with a predilection for immunocompromised individuals, and the disease burden of lymphoid neoplasms has been rising globally over the last decade. At the same time, mounting...
Prognostic Nomogram for Patients With Pancreatic Ductal Adenocarcinoma of Pancreatic Head After Pancreaticoduodenectomy [0.03%]
胰头癌术后患者的预后预测 nomogram模型
Hongkai Zhuang,Zixuan Zhou,Zuyi Ma et al.
Hongkai Zhuang et al.
Background: The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) of pancreatic head remains poor, even after potentially curative R0 resection. The aim of this study was to develop an accurate model to p...
Tumour Seeding After a Thoracic Biopsy for Renal Cell Carcinoma: A Case Report and a Review of the Literature [0.03%]
胸腔活检后肾细胞癌转移一例及文献复习
Dionese Michele,Basso Umberto,Ramondo Gaetano et al.
Dionese Michele et al.
The role of percutaneous tumour biopsies had gain importance in the management of renal cell carcinoma to provide diagnostic specimen for the patients with metastatic disease that could benefit a systemic treatment. Among the possible compl...
Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids [0.03%]
andrographolide和褪黑素联合药物治疗对转移性结肠癌细胞和类器官的影响
Neha Sharda,Tamaki Ikuse,Elizabeth Hill et al.
Neha Sharda et al.
Background: The death rate (the number of deaths per 100 000 people per year) of colorectal cancer (CRC) has been dropping since 1980 due to increased screening, lifestyle-related risk factors, and improved treatment opti...
MicroRNA-19b Downregulates NR3C1 and Enhances Oxaliplatin Chemoresistance in Colon Cancer via the PI3K/AKT/mTOR Pathway [0.03%]
microRNA-19b通过PI3K/AKT/mTOR信号通路下调NR3C1并增强奥沙利铂诱导的结肠癌耐药性
Zhongbo Han,Chao Zhang,Qingfeng Wang et al.
Zhongbo Han et al.
Background: Identifying the genes and signaling pathways related to chemoresistance might facilitate the development of novel therapeutic strategies for colon cancer. In this study, we aimed to investigate the biological ...
Complete Radiological Response of Recurrent Metastatic Adrenocortical Carcinoma to Pembrolizumab and Mitotane [0.03%]
帕博利珠单抗和米托坦治疗转移性肾上腺皮质癌复发后的完全放射学反应
Walid Alam,Youssef Bouferraa,Yolla Haibe et al.
Walid Alam et al.
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. Treatment options for ACC are limited, with resection the main intervention. Most cases present in late metastatic cases, and data regarding effective therapies is l...
Machine Learning Can Predict Total Death After Radiofrequency Ablation in Liver Cancer Patients [0.03%]
机器学习可以预测射频消融肝癌患者的总生存率
Jianhua Tong,Panmiao Liu,Muhuo Ji et al.
Jianhua Tong et al.
Objective: Over 1 million new cases of hepatocellular carcinoma (HCC) are diagnosed worldwide every year. Its prognosis remains poor, and the 5-year survival rate in all disease stages is estimated to be between 10% and 2...
Dae-Lyong Ha,Min-Young Yang,Jun-Oh Shin et al.
Dae-Lyong Ha et al.
Background: When physicians see an umbilical nodule, most of them instinctively recall the Sister Mary Joseph nodule. Therefore, dermatologists need to recognize umbilical dermatoses that can be mistaken for the Sister Ma...