How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies? [0.03%]
三种欧洲儿科处方集中的抗菌药物剂量推荐的一致性如何？
Lukas Higi,Elisabeth Carydias,Andrea M Burden et al.
Lukas Higi et al.
Background: Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited amount of label information, several paediatric drug formularies have been developed. ...
A Perri,S Fattore,A Sbordone et al.
A Perri et al.
The prevention, recognition, and treatment of pain is crucial in the management of neonates. Infants do not tolerate pain better than adults; indeed, the immaturity of the endogenous antalgic system means they exhibit an increased stress re...
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia [0.03%]
儿科肺炎患者哌拉西林的人群药代动力学和剂量优化研究
Totsapol Jirasomprasert,Li-Yuan Tian,Dian-Ping You et al.
Totsapol Jirasomprasert et al.
Objective: We aimed to determine the piperacillin disposition and optimize the dosing regimens for infants and children with pneumonia. Methods: ...
Janet Wozniak,Hannah O&#x;Connor,Maria Iorini et al.
Janet Wozniak et al.
Despite an opportunity to prevent adult psychopathology associated with bipolar disorder through early diagnosis in children, there is insufficient information and awareness among healthcare providers about the unique features and treatment...
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis [0.03%]
高保真的临床模拟可改善儿科临床试验设计：吸取的教训以及投资回报率（ROI）和参与度回报率（ROE）分析的概念化
Jose Maria Quintillá,Carmen de la Gala,Ruben Berrueco et al.
Jose Maria Quintillá et al.
Introduction: Clinical trials entail complex processes that are more challenging when they are addressed to pediatric patients and include a decentralized design. High-realistic simulation allows for the testing and refin...
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study [0.03%]
关于右美托咪定用于表面活性剂非侵入性给药的临床研究
Sagee Nissimov,Amitai Kohn,Rimona Keidar et al.
Sagee Nissimov et al.
Introduction: Less invasive surfactant administration (LISA) involves delivering surfactant to a spontaneously breathing infant by passing a thin catheter through the vocal cords and has become the preferred method for su...
Hannah A Blair
Hannah A Blair
Apremilast (Otezla®) is an inhibitor of phosphodiesterase-4 (PDE-4) being developed by Amgen. It is approved in multiple countries worldwide, including the USA and those of the EU, for the treatment of adults with psoriatic arthritis, plaq...
Pharmacokinetics and Safety of Endotracheal Lidocaine for Endotracheal Intubation in Critically Ill Children [0.03%]
经气管给药利多卡因在危重病儿气管插管中的药代动力学和安全性研究
Jordan Anderson,Erin B Owen,Shannon Mayes et al.
Jordan Anderson et al.
Introduction: Critically ill pediatric patients are endotracheally intubated in pediatric intensive care units for a variety of illnesses and indications. Management of an endotracheal tube (ETT) requires suctioning to re...
Therapeutic Drug Monitoring of Antimicrobial Drugs in Children with Cancer: A New Tool for Personalized Medicine [0.03%]
儿童抗微生物药物治疗性药物监测：个性化医疗的新工具
Riccardo Masetti,Gianluca Bossù,Edoardo Muratore et al.
Riccardo Masetti et al.
The risk of fungal, bacterial, and viral infections is higher in children with hematological and solid malignancies, particularly during periods of profound neutropenia. Although early administration of antimicrobial agents is common, optim...
Optimizing Pediatric Sedation: Evaluating Remimazolam and Dexmedetomidine for Safety and Efficacy in Clinical Practice [0.03%]
儿科镇静优化：评估瑞米唑兰和右美托咪啶的安全性和有效性临床实践中的
Vera Scheckenbach,Frank Fideler
Vera Scheckenbach
Daily, children undergo countless investigations and interventions, which require sedation and immobilization to ensure safety and accuracy. This remains associated with a persistent risk of sedation-induced life-threatening events as child...