Pediatric Chronic Inflammatory Demyelinating Polyneuropathy: Challenges in Diagnosis and Therapeutic Strategies [0.03%]
儿童慢性炎症性脱髓鞘多发性神经病的诊断与治疗策略挑战
Issa Alawneh,Asmaa Alenizi,Freddy Paiz et al.
Issa Alawneh et al.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune neurological disorder seen in both pediatric and adult populations. CIDP typically presents with progressive and persistent weakness over at least 4 weeks in addi...
Comparison of Different Doses of Oral and Ocular Propranolol for Retinopathy of Prematurity: A Network Meta-Analysis [0.03%]
不同剂量口服及阿托品化下普奈洛尔治疗早产儿视网膜病变的优劣比较：网络 meta 分析
Amparo Ortiz-Seller,Pablo Martorell,Patricia Roselló et al.
Amparo Ortiz-Seller et al.
Objective: The efficacy and safety of propranolol for retinopathy of prematurity (ROP) remain under debate. This network meta-analysis (NMA) focuses on whether a ranking may be established for different dose levels of pro...
Meta-Analysis
Paediatric drugs. 2024 Sep;26(5):499-518. DOI:10.1007/s40272-024-00647-5 2024
Clinical Evidence Supporting FDA Approval of Gene and RNA Therapies for Rare Inherited Conditions [0.03%]
支持FDA批准用于罕见遗传性疾病的基因和RNA疗法的临床证据
Ilina C Odouard,Jeromie Ballreich,Branden Lee et al.
Ilina C Odouard et al.
Background: Gene and RNA therapies have potential to transform the treatment of rare inherited diseases, but there are concerns about the evidence supporting their use and high costs. ...
Methotrexate Intolerance in Juvenile Idiopathic Arthritis: Definition, Risks, and Management [0.03%]
儿童特发性关节炎中的甲氨蝶呤不耐受：定义、风险及处理措施
Camilla Wibrand,Nini Kyvsgaard,Troels Herlin et al.
Camilla Wibrand et al.
Juvenile idiopathic arthritis is the most common rheumatic disorder in childhood and adolescence posing a significant threat of short-term and long-term disability if left untreated. Methotrexate is a folic acid analog with various immunomo...
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review [0.03%]
先天性心脏病儿童的药物不良反应：系统综述
Esmaeel Toni,Haleh Ayatollahi,Reza Abbaszadeh et al.
Esmaeel Toni et al.
Background: Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in children, can prolong their survival. The drugs prescribed for children with CHD are m...
Drug-Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study [0.03%]
一项回顾性研究：危重药物相互作用在儿科重症监护患者中导致相关症状
Lisa Marie Kiesel,Astrid Bertsche,Wieland Kiess et al.
Lisa Marie Kiesel et al.
Background: Children treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined as high-alert medications (HAMs). Those drugs carry a high risk of causing patient harm...
Elizabeth A Hall,Tracy M Hagemann,Chasity M Shelton et al.
Elizabeth A Hall et al.
Opioid therapy is the mainstay for managing pain in pediatric oncology. This narrative review describes the current literature regarding opioids for pediatric cancer pain. The review explores the multifaceted landscape of opioid utilization...
Annegret Dahlmann-Noor,Jill Bloom,Saw Keng Lee et al.
Annegret Dahlmann-Noor et al.
Many conditions managed by pediatric ophthalmologists are rare diseases, and even if pharmacological treatments are available, these have often not been evaluated in children. Off-label prescribing is a common practice in pediatric ophthalm...
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making [0.03%]
机器学习：一种潜在的辅助新生儿治疗决策的工具
Bo-Hao Tang,Qiu-Yue Li,Hui-Xin Liu et al.
Bo-Hao Tang et al.
Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable methods for early recognition and diagnosis of bacterial infections and early individualization of antibacterial drug a...
Pediatric Treatment-Resistant Obsessive Compulsive Disorder: Treatment Options and Challenges [0.03%]
难治性儿童强迫症的治疗选择及挑战
Sana Younus,Lauren Havel,Jordan T Stiede et al.
Sana Younus et al.
Pediatric obsessive-compulsive disorder (OCD) is a chronic, potentially debilitating psychiatric condition. Although effective treatments exist, at least 10% of youth do not achieve remission despite receiving first-line treatments. This ar...