Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients [0.03%]
儿童患者中ketoprofen的药代动力学、疗效和耐受性
Hannu Kokki
Hannu Kokki
The NSAID ketoprofen is used widely in the management of inflammatory and musculoskeletal conditions, pain, and fever in children and adults. Pharmacokinetic studies show that drug exposure after a single intravenous dose is similar in chil...
Emma Harris,Sven M Schulzke,Sanjay K Patole
Emma Harris
Sepsis, necrotizing enterocolitis (NEC), and chronic lung disease (CLD) in preterm neonates are associated with significant mortality and morbidity, including long-term neurodevelopmental impairment and socioeconomic burden. Safe and effect...
Steven M Smith,John G Gums
Steven M Smith
Influenza infection is annually responsible for significant morbidity and mortality, particularly among the very young and old. Recently updated guidelines recommend influenza vaccination of all children aged 6 months to 18 years; however, ...
Hepatic veno-occlusive disease: a chemotherapy-related toxicity in children with malignancies [0.03%]
儿童恶性肿瘤相关化疗引起的肝静脉闭塞性疾病
Maria Giuseppina Cefalo,Palma Maurizi,Annalisa Arlotta et al.
Maria Giuseppina Cefalo et al.
Hepatic veno-occlusive disease (VOD) is a major manifestation of liver toxicity associated with conventional and high-dose chemotherapy in children affected by hematologic malignancies and certain solid tumors. Clinically, patients present ...
A randomized trial of propranolol versus sodium valproate for the prophylaxis of migraine in pediatric patients [0.03%]
一项关于普萘洛尔和戊酸钠预防儿童患者偏头痛的随机试验
Elham Bidabadi,Mehryar Mashouf
Elham Bidabadi
Background: Migraine is the most common of the paroxysmal disorders to affect the brain in the pediatric population. Both propranolol and sodium valproate (valproic acid) have been advocated as prophylactic agents for chi...
Randomized Controlled Trial
Paediatric drugs. 2010 Aug 1;12(4):269-75. DOI:10.2165/11316270-000000000-00000 2010
Didier G Ebo,Marjoke M Verweij,Kathleen J De Knop et al.
Didier G Ebo et al.
Hereditary angioedema (HAE) is an inherited disorder characterized by recurrent, circumscribed, non-pitting, non-pruritic, and rather painful subepithelial swelling of sudden onset, which fades during the course of 48-72 hours, but can pers...
Rotavirus infections and vaccines: burden of illness and potential impact of vaccination [0.03%]
轮状病毒感染和疫苗：疾病负担及免疫接种的影响
Keith Grimwood,Stephen B Lambert,Richard J Milne
Keith Grimwood
Rotaviruses are the most common cause of severe gastroenteritis in children. By 5 years of age virtually every child worldwide will have experienced at least one rotavirus infection. This leads to an enormous disease burden, where every min...
Understanding developmental pharmacodynamics: importance for drug development and clinical practice [0.03%]
理解发育性药动学的重要性：对药物开发和临床实践的影响
Hussain Mulla
Hussain Mulla
Developmental pharmacodynamics is the study of age-related maturation of the structure and function of biologic systems and how this affects response to pharmacotherapy. This may manifest as a change in the potency, efficacy, or therapeutic...
Mometasone furoate in children with mild to moderate persistent asthma: a review of the evidence [0.03%]
莫米松呋喃诺在轻中度持续性哮喘儿童中的应用：证据回顾
Henry Milgrom
Henry Milgrom
The high prevalence of asthma in pediatric patients underscores the need for effective and safe treatment in this population. Current treatment guidelines recommend inhaled corticosteroids (ICSs) as a preferred treatment for the control of ...
The Viriato study: update on antimicrobial resistance of microbial pathogens responsible for community-acquired respiratory tract infections in Portugal [0.03%]
2015年葡萄牙社区获得性下呼吸道感染病原菌耐药性Viriato研究更新报告
José Melo-Cristino,Letícia Santos,Catarina Silva-Costa et al.
José Melo-Cristino et al.
The Viriato study is a prospective, multicentre laboratory-based surveillance study of antimicrobial susceptibility in which 30 microbiology laboratories throughout Portugal are asked to isolate, identify and submit to a central laboratory ...