Juvenile Dermatomyositis: Updates in Pathogenesis and Biomarkers, Current Treatment, and Emerging Targeted Therapies [0.03%]
皮肌炎的新进展：发病机制和生物标志物、目前的治疗以及新兴靶向疗法
Hanna Kim
Hanna Kim
Juvenile dermatomyositis is a rare systemic inflammatory autoimmune disease involving muscle, skin, and vessels. Most patients do not fully respond to initial therapy, instead having a chronic refractory or polycyclic disease course. Pathog...
Gabriele Canciani,Francesco Fabozzi,Claudia Pinacchio et al.
Gabriele Canciani et al.
Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies, inducing notable and durable clinical responses. However, for solid tumors, including but not limited to pediatric tumors, several pecu...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System [0.03%]
基于美国食品药品管理局不良事件报告系统的小儿专利动脉导管一线用药的药品不良事件信号检测研究
Kannan Sridharan,Gowri Sivaramakrishnan
Kannan Sridharan
Background: Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure in preterm neonates. However, their relative safety profiles remain unclear. ...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain [0.03%]
儿科肿瘤疼痛的叙事性回顾：程序性和外科手术性疼痛的阿片类药物选择
Elizabeth A Hall,Chasity M Shelton,Tracy M Hagemann et al.
Elizabeth A Hall et al.
This narrative review examines the evolving role of opioids in managing procedural and surgical pain in pediatric oncology patients. The review evaluates studies on opioid use across various oncological surgeries including thoracic, abdomin...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study [0.03%]
一项前瞻性研究：LEV和VPA治疗对癫痫患儿愤怒情绪及注意力缺陷多动障碍临床特点的影响
Zeynep Vatansever Pınar,Safiye Güneş Sağer,İrem Damla Çimen et al.
Zeynep Vatansever Pınar et al.
Background and objective: Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacerbation of psychiatric symptoms such as irritability, aggression, and hype...
Observational Study
Paediatric drugs. 2024 Nov;26(6):753-765. DOI:10.1007/s40272-024-00652-8 2024
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review [0.03%]
杜氏肌营养不良症患者使用Vamorolone的有效性和安全性的系统评价
Carlos Pascual-Morena,Maribel Lucerón-Lucas-Torres,Irene Martínez-García et al.
Carlos Pascual-Morena et al.
Background: Vamorolone has recently been approved for the management of Duchenne muscular dystrophy to replace glucocorticosteroids, which theoretically have more side effects. However, its efficacy and safety profile is ...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis [0.03%]
儿科远端肾小管酸中毒治疗的新进展
Olivia Boyer,Mélissa Ould Rabah,Evgenia Preka
Olivia Boyer
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells of the collecting duct, leading to impaired urine acidification and resulting in metabolic acidosis, hypokalemia, and hyp...
Role of mTOR Inhibitors in Pediatric Liver Transplant Recipients: A Systematic Review [0.03%]
雷帕霉素靶蛋白抑制剂在儿童肝移植受者中作用的系统评价
Marjan Moghadamnia,Simin Dashti-Khavidaki,Hosein Alimadadi
Marjan Moghadamnia
Background: Immunosuppressive medications play a crucial role in determining both organ and patient survival following liver transplantation (LT). Typically, immunosuppressive protocols for pediatric LT patients rely on c...
Preventing Recurrence of Crohn's Disease Post-Ileocaecal Surgery in Paediatric Patients: A Therapy Guide Based on Systematic Review of the Evidence [0.03%]
基于系统评价的证据制定儿童回肠Crohn病术后复发的治疗指南
Jiri Bronsky,Kristyna Zarubova,Michal Kubat et al.
Jiri Bronsky et al.
Background and aims: Ileocaecal resection (ICR) is frequent in paediatric patients with Crohn's disease (pCD). Despite rates of reoperation being low, the risk of clinical or endoscopic post-operative recurrence (POR) is ...
Sithara Ramdas,Teresa Painho,Maria I Vanegas et al.
Sithara Ramdas et al.
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is a treatable condition with most patients requiring immunosuppression for disease control and/or remission. Juvenile m...