Jamie D Croxtall
Jamie D Croxtall
Valsartan is an oral angiotensin II subtype 1 receptor antagonist with well established antihypertensive efficacy in adults. It is now approved in the EU and the US for the treatment of hypertension in children and adolescents. In two, rand...
From adults to children: simulation-based choice of an appropriate sparse-sampling schedule [0.03%]
从成人到儿童：基于模拟的稀疏采样适当时间的选择
Stefanie Reif,Marcus Schultze-Mosgau,Gabriele Sutter
Stefanie Reif
Background: According to the International Conference on Harmonisation guideline E11, pharmacokinetic (PK) bridging studies can be applied to support pediatric drug development. However, for PK studies in infants and chil...
Takako Miyamae
Takako Miyamae
Cryopyrin-associated periodic syndromes (CAPS) are a group of rare autoinflammatory disorders; many cases of CAPS are caused by mutations in the NLRP3 gene. In these conditions, interleukin (IL)-1 is overproduced, and this overproduction pl...
Safety and tolerability of loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension in pediatric subjects [0.03%]
0.5%洛特贝松和0.3%托布拉霉素眼科混悬液在儿科受试者中的安全性和耐受性
Timothy L Comstock,Michael R Paterno,Kirk M Bateman et al.
Timothy L Comstock et al.
Background: Loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension (LE/T) is indicated for steroid-responsive inflammatory ocular conditions where superficial bacterial ocular infection or a risk of bacteria...
Randomized Controlled Trial
Paediatric drugs. 2012 Apr 1;14(2):119-30. DOI:10.2165/11596320-000000000-00000 2012
Emma D Deeks
Emma D Deeks
Atazanavir is a selective and potent inhibitor of the HIV-1 protease. The drug is administered in combination with low-dose ritonavir, to boost atazanavir pharmacokinetics (i.e. ritonavir-boosted atazanavir), and other antiretroviral agents...
Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents [0.03%]
用于辅助青少年戒烟的药物治疗的有效性和耐受性
Steffani R Bailey,Erin E Crew,Emily C Riske et al.
Steffani R Bailey et al.
Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacolo...
Luc De Catte,Bart De Keersmaeker,Filip Claus
Luc De Catte
The low prevalence of fetal CNS anomalies results in a restricted level of exposure to, and limited experience for most obstetricians involved in, prenatal ultrasound. Sonographic guidelines for screening the fetal brain in a systematic way...
Aniruddh V Deshpande,Patrina H Y Caldwell
Aniruddh V Deshpande
Nocturnal enuresis, or bedwetting, is the most common cause of urinary incontinence in children. It is known to have a significant psychosocial impact on the child as well as the family. Nocturnal enuresis typically presents as failure to b...