Managing bronchiolitis obliterans syndrome (BOS) and chronic lung allograft dysfunction (CLAD) in children: what does the future hold? [0.03%]
儿童闭塞性细支气管炎（BOS）和慢性移植物肺功能障碍（CLAD）的管理：未来何去何从？
Gregory I Snell,Miranda Paraskeva,Glen P Westall
Gregory I Snell
The success of pediatric lung transplantation continues to be limited by long-term graft dysfunction. Historically this has been characterized as an obstructive spirometric defect in the form of the bronchiolitis obliterans syndrome (BOS). ...
Safety and pharmacokinetics of atypical antipsychotics in children and adolescents [0.03%]
非典型抗精神病药物在儿童和青少年中的安全性及药代动力学特点
Silvio Caccia
Silvio Caccia
Pediatric behavioral and affective disorders often require antipsychotic therapy, in combination with psychotherapeutic interventions, for their treatment and stabilization. Although pharmacotherapy can include either typical or atypical an...
Better drug therapy for the children of Africa: current impediments to success and potential strategies for improvement [0.03%]
改善非洲儿童药物治疗现状：当前障碍及潜在对策
Stuart M Macleod,Janet K Finch,William M Macharia et al.
Stuart M Macleod et al.
A commentary is presented on the urgent need for a comprehensive effort to improve the practice of pediatric therapeutics in Africa. A call for action is addressed to a variety of practitioners internationally, many of whom possess skills t...
Sarita Dhuper,Sujatha Buddhe,Sunil Patel
Sarita Dhuper
The scientific, medical, and lay communities are currently confronted with a serious medical and public health problem related to the marked non-remitting worldwide epidemic of obesity. This ever-increasing prevalence of obesity is accompan...
Alexandra Adams,Sejal Saglani
Alexandra Adams
Asthma continues to be one of the greatest burdens to healthcare resources throughout the developed world. In most cases, good symptom control can be achieved with low-dose inhaled corticosteroids, and can be cared for in the primary and se...
Çiçek Wöber-Bingöl
Çiçek Wöber-Bingöl
Migraine is a common disease in children and adolescents. The incidence of migraine has increased alarmingly in the general population during recent decades. Migraine causes considerable individual suffering and impaired quality of life. Th...
Topical calcineurin inhibitors for atopic dermatitis: review and treatment recommendations [0.03%]
特应性皮炎的外用钙调神经磷酸酶抑制剂：综述和治疗推荐
Warner W Carr
Warner W Carr
Atopic dermatitis (AD) is an inflammatory skin disease commonly affecting children and managed by pediatricians, primary care physicians, allergists, and dermatologists alike. For many years, the only available topical pharmacological treat...
Bipolar depression in pediatric populations : epidemiology and management [0.03%]
儿科人群的双相抑郁的流行病学和治疗措施研究
Victoria E Cosgrove,Donna Roybal,Kiki D Chang
Victoria E Cosgrove
Depression in children and adolescents with bipolar disorder is more commonly observed than mania or hypomania, and is associated with significant functional disability in multiple environmental realms. Optimal management of pediatric bipol...
Cancer pharmacogenomics in children: research initiatives and progress to date [0.03%]
儿童肿瘤药物基因组学：研究计划和迄今进展
Shahrad Rod Rassekh,Colin J D Ross,Bruce C Carleton et al.
Shahrad Rod Rassekh et al.
Over the last few decades, cure rates for pediatric cancer have increased dramatically, and now over 80 % of children with cancer are cured of their disease. This improvement in cure has come with a significant cost, with many children suff...
Premenstrual dysphoric disorder and severe premenstrual syndrome in adolescents [0.03%]
青春期前的经前期烦躁障碍和严重的经前期综合征
Andrea J Rapkin,Judith A Mikacich
Andrea J Rapkin
Numerous epidemiologic studies have demonstrated that premenstrual disorders (PMDs) begin during the teenage years. At least 20 % of adolescents experience moderate-to-severe premenstrual symptoms associated with functional impairment. Prem...