Olympia A Tsilochristou,Nikolaos Douladiris,Michael Makris et al.
Olympia A Tsilochristou et al.
The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of 'united airways disease' or 'respiratory allergy', implying that allergy, in its widest sense, underlies this clinical sy...
Metformin in the treatment of obese children and adolescents at risk of type 2 diabetes [0.03%]
二甲双胍治疗肥胖的10至16岁有患2型糖尿病风险的儿童和青少年患者的效果：一项随机临床试验
Deborah L Kendall,Rakesh Amin,Peter E Clayton
Deborah L Kendall
Metformin is the first-line treatment for type 2 diabetes (T2D) in adults, children and young people, particularly in obese or overweight patients. Many studies have demonstrated that metformin is associated with weight reduction in adults ...
D Thangarajah,M O&#x;Meara,A Dhawan
D Thangarajah
The success of paediatric liver transplantation is attributed to improved surgical techniques and the advent of calcineurin inhibitor-based immunosuppression. Acute rejection (AR) rarely results in graft loss with calcineurin inhibitor immu...
Pediatric health care quality measures: considerations for pharmacotherapy [0.03%]
儿科保健质量衡量标准：药物治疗的考虑因素
Edwin A Lomotan,Denise Dougherty
Edwin A Lomotan
Measuring the quality use of medicines can be conceptualized as a mechanism for understanding appropriate use, underuse, overuse, or misuse. For pediatric pharmacotherapy, measuring the quality use of medicines requires awareness of the dif...
Anna Pecoraro,Marc Fishman,Michelle Ma et al.
Anna Pecoraro et al.
Opioid misuse, abuse, and dependence are global problems whose patterns vary across cultures. In the USA, the non-medical use of prescription opioids has become particularly serious because of its association with addiction and overdose dea...
Jana Dekrem,Kristel Van Calsteren,Frédéric Amant
Jana Dekrem
Approximately 1 in 1,000-2,000 pregnancies are complicated by cancer. Today, different treatment options are considered as safe during pregnancy: chemotherapy, radiotherapy, surgery, or a combination of these. Surgery is considered safe dur...
Kara Heelan,Neil H Shear
Kara Heelan
Cutaneous drug reactions account for a large proportion of adverse drug reactions. Cutaneous drug reactions can be very challenging to diagnose. They can mimic many other skin diseases; this is especially evident during childhood, when vira...
Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial [0.03%]
利鲁唑联合利培酮治疗自闭症儿童易激惹的疗效：一项安慰剂对照、随机双盲试验
Ali Ghaleiha,Effat Mohammadi,Mohammad-Reza Mohammadi et al.
Ali Ghaleiha et al.
Background: A hyperglutamatergic state has been shown to play a possible role in the pathophysiology of autistic disorders. Riluzole is a glutamate-modulating agent with neuroprotective properties, which has been shown to...
Randomized Controlled Trial
Paediatric drugs. 2013 Dec;15(6):505-14. DOI:10.1007/s40272-013-0036-2 2013
Glucocorticoids in the management of systemic juvenile idiopathic arthritis [0.03%]
糖皮质激素在全身型幼年特发性关节炎治疗中的作用
Gaia Vannucci,Luca Cantarini,Teresa Giani et al.
Gaia Vannucci et al.
Glucocorticoids have been the mainstay of treatment for many years in systemic-onset juvenile idiopathic arthritis (sJIA), causing important side effects and some difficulties in the management of this disease. Until the introduction of bio...
Optimal management of Ewing sarcoma family of tumors: recent developments in systemic therapy [0.03%]
Ewing肉瘤家族肿瘤的综合治疗：化疗新进展
Cormac Owens,Lesleigh S Abbott,Abha A Gupta
Cormac Owens
The Ewing sarcoma family of tumors (ESFT) is defined by cell surface expression of CD99 and a translocation involving EWS and an ETS partner. Cytotoxic chemotherapy remains the benchmark of first- and second-line therapy, and although the m...