Standard-dose versus high-dose acyclovir in children treated empirically for encephalitis: a retrospective cohort study of its use and safety [0.03%]
阿昔洛韦治疗儿童脑炎的标准剂量与高剂量的回顾性队列研究：使用情况和安全性分析
Jennifer G Kendrick,Mary H H Ensom,Andrew Steer et al.
Jennifer G Kendrick et al.
Background: Intravenous acyclovir is the treatment of choice for herpes simplex virus encephalitis. In 2006, the American Academy of Pediatrics updated its dosing recommendations for children aged 3 months to 12 years to ...
Faisal S Malik,Craig E Taplin
Faisal S Malik
Treatment of type 1 diabetes mellitus (T1DM) requires lifelong administration of exogenous insulin. The primary goal of treatment of T1DM in children and adolescents is to maintain near-normoglycemia through intensive insulin therapy, avoid...
Antidepressant drugs and the risk of suicide in children and adolescents [0.03%]
抗抑郁药物与儿童及青少年自杀风险的关系
Göran Isacsson,Charles L Rich
Göran Isacsson
Government agencies have issued warnings about the use of antidepressant medications in children, adolescents, and young adults since 2003. The statements warn that such medications may cause de novo 'suicidality' in some people. This revie...
Christopher Brasher,Benjamin Gafsous,Sophie Dugue et al.
Christopher Brasher et al.
Many factors contribute to suboptimal pain management in children. Current evidence suggests that severe pain in children has significant long-lasting effects, even more so than in adults. In particular, recent evidence suggests a lack of o...
Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity [0.03%]
用于早产儿呼吸暂停治疗和预防的甲基黄嘌呤类药物的应用
Katherine Schoen,Tian Yu,Chris Stockmann et al.
Katherine Schoen et al.
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % of neonates with a birth weight less than 1,000 g. Methylxanthine therapies, including caffeine and theophylline, are a mainstay in the treat...
Marjet J A M Braamskamp,Barbara A Hutten,Albert Wiegman et al.
Marjet J A M Braamskamp et al.
Cardiovascular disease (CVD) remains the leading cause of death and morbidity in our society. One of the major risk factors for CVD is hypercholesterolemia. Hypercholesterolemia in children can be caused by a hereditary disorder or can be s...
Raltegravir: a review of its use in the management of HIV-1 infection in children and adolescents [0.03%]
拉替拉韦用于儿童和青少年HIV-1感染治疗的评价
Caroline M Perry
Caroline M Perry
Raltegravir (ISENTRESS(®)) is an HIV-1 integrase strand transfer inhibitor that is well established as a component of highly active antiretroviral therapy regimens for the treatment of adults with HIV-1 infection, and has recently been app...
Long-acting growth hormone [0.03%]
长效生长激素
Charlotte Höybye,Jens Sandahl Christiansen
Charlotte Höybye
Considerations in the pharmacologic treatment and prevention of neonatal sepsis [0.03%]
新生儿败血症的药物治疗和预防措施之考量
Chris Stockmann,Michael G Spigarelli,Sarah C Campbell et al.
Chris Stockmann et al.
The management of neonatal sepsis is challenging owing to complex developmental and environmental factors that contribute to inter-individual variability in the pharmacokinetics and pharmacodynamics of many antimicrobial agents. In this rev...
Relapsed and refractory pediatric acute myeloid leukemia: current and emerging treatments [0.03%]
复发和难治性儿童急性髓系白血病的现有及新兴治疗方法
Jennifer Davila,Emily Slotkin,Thomas Renaud
Jennifer Davila
Survival rates for children with acute myeloid leukemia (AML) exceed 60 % when modern, intensified chemotherapeutic regimens and enhanced supportive care measures are employed. Despite well-recognized improvements in outcomes, primary refra...