Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study [0.03%]
儿科患者使用Xa因子抑制剂的不良事件：一项meta分析和药物警戒研究
Shan Chong,Lan Sun,Guangyan Mu et al.
Shan Chong et al.
Background: This study aimed to provide a comprehensive review of adverse events (AEs) associated with factor Xa (FXa) inhibitors in pediatric patients. M...
Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark [0.03%]
丹麦孕期和哺乳期注意缺陷多动障碍药物使用的流行率及时间趋势
Malene Galle Madsen,Jin Liang Zhu,Trine Munk-Olsen et al.
Malene Galle Madsen et al.
Background and objectives: Females of reproductive age are increasingly using attention deficit hyperactivity disorder (ADHD) medication, but its use during pregnancy and breastfeeding is largely unknown. The aim of this ...
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature [0.03%]
安卡拉用于新生儿和婴儿（≤3个月）炎症性疾病的超说明书用药：案例系列及文献回顾
Domenico Umberto De Rose,Francesca Campi,Chiara Maddaloni et al.
Domenico Umberto De Rose et al.
Background: Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of different autoinflammatory diseases, blocking its pathway has become an important ther...
Ganaxolone: A Review in Epileptic Seizures Associated with Cyclin-Dependent Kinase-Like 5 Deficiency Disorder [0.03%]
ganaxolone治疗cyclin依赖性激酶样5缺乏综合征相关癫痫发作的评价
Sheridan M Hoy
Sheridan M Hoy
Oral ganaxolone (ZTALMY®), a synthetic analogue of the endogenous neuroactive steroid allopregnanolone, acts as a positive allosteric modulator of synaptic and extra-synaptic γ-aminobutyric acid (GABA) type A receptor function in the CNS....
Dexmedetomidine for Less Invasive Surfactant Administration: Another Promising Medicine in an Ever-Growing Toolbox? [0.03%]
对于表面活性剂非侵入性给药丁丙诺啡是否是一种日益增多的工具箱中的另一种有前景的药物？
Christian A Maiwald,Karel Allegaert
Christian A Maiwald
Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment [0.03%]
早产儿坏死性肠炎的内脏疼痛：潜在机制及治疗意义
Judith A Ten Barge,Gerbrich E van den Bosch,Rebeccah Slater et al.
Judith A Ten Barge et al.
Necrotizing enterocolitis (NEC) is a relatively rare but very severe gastrointestinal disease primarily affecting very preterm infants. NEC is characterized by excessive inflammation and ischemia in the intestines, and is associated with pr...
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered? [0.03%]
多发性硬化患儿的药物选择优化：我们了解多少？仍有何未解之谜？
Rabporn Suntornlohanakul,E Ann Yeh
Rabporn Suntornlohanakul
Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis with onset before 18 years of age. It is characterized by a more inflammatory course, more frequent clinical relapses, and a greater number of magnetic resonance imaging...
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways [0.03%]
杜氏肌营养不良症药物的新视角：改善呼吸结局和改进监管路径的建议
David J Birnkrant,Jane B Black,Daniel W Sheehan et al.
David J Birnkrant et al.
New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achieving regulatory approval prematurely. It is the cardiorespiratory complications of DMD that cause the disease's major ...
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies? [0.03%]
三种欧洲儿科处方集中的抗菌药物剂量推荐的一致性如何？
Lukas Higi,Elisabeth Carydias,Andrea M Burden et al.
Lukas Higi et al.
Background: Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited amount of label information, several paediatric drug formularies have been developed. ...
A Perri,S Fattore,A Sbordone et al.
A Perri et al.
The prevention, recognition, and treatment of pain is crucial in the management of neonates. Infants do not tolerate pain better than adults; indeed, the immaturity of the endogenous antalgic system means they exhibit an increased stress re...