Connie Kang
Connie Kang
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed by Regeneron Pharmaceuticals, Inc. and Sanofi (formerly sanofi-aventis), is approved globally for use in adults with estab...
Lin Song,Ni Zhang,Ting-Ting Jiang et al.
Lin Song et al.
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and assist in paediatric drug development. In 2014, the National Health and Family Planning Commission (now known as the Na...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update [0.03%]
儿科神经精神系统性红斑狼疮的诊断和治疗：最新研究动态分析
Dilara Unal,Veysel Cam,Hulya Ercan Emreol et al.
Dilara Unal et al.
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. The presentation and severity of neuropsychiatric involvement in SLE may show considerable variability. The disease can...
Sohita Dhillon
Sohita Dhillon
Inotuzumab ozogamicin (BESPONSA™) is a CD22-targeted monoclonal antibody drug conjugate (ADC) developed by Pfizer for the treatment of CD22-postive B-cell precursor acute lymphoblastic leukaemia (ALL). Inotuzumab ozogamicin comprises a hum...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN [0.03%]
英夫利西单抗治疗儿童溃疡性结肠炎的疗效和安全性：一项儿科IBD波尔图小组多中心回顾性研究
Shlomi Cohen,Helena Rolandsdotter,Kaija-Leena Kolho et al.
Shlomi Cohen et al.
Background and objectives: Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (IBDU) are limited. We aimed to evaluate the effectiveness and safety of u...
A Pilot Study of Ketotifen in Patients Aged 8-17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia [0.03%]
ketotifen治疗8至17岁功能性消化不良伴粘膜嗜酸性粒细胞增多症患儿的临床研究
Chance S Friesen,Valentina Shakhnovich,Paul Toren et al.
Chance S Friesen et al.
Background and objective: Mast cells have been implicated in abdominal pain-associated disorders of gut-brain interaction, such as functional dyspepsia. As such, ketotifen, a second-generation antihistamine and mast cell ...
Randomized Controlled Trial
Paediatric drugs. 2024 Jul;26(4):451-457. DOI:10.1007/s40272-024-00628-8 2024
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study [0.03%]
长时间连续使用氯胺酮对重症儿童的影响：一项前瞻性队列研究
Paulo Sérgio Lucas da Silva,Emerson Yukio Kubo,Rafael da Motta Ramos Siqueira et al.
Paulo Sérgio Lucas da Silva et al.
Background: Ketamine has been considered as an adjunct for children who do not reach their predefined target sedation depth. However, there is limited evidence regarding the use of ketamine as a prolonged infusion (i.e., ...
Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians [0.03%]
儿科药物个性化给药：临床医生的儿科药理学入门教程
Kevin Meesters,Violeta Balbas-Martinez,Karel Allegaert et al.
Kevin Meesters et al.
The widespread use of drugs for unapproved purposes remains common in children, primarily attributable to practical, ethical, and financial constraints associated with pediatric drug research. Pharmacometrics, the scientific discipline that...
Aslı İnci,Fatih Süheyl Ezgü,Leyla Tümer
Aslı İnci
Inborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a metabolic/biochemical pathway or other disturbances in the metabolic pathway including transport protein o...
Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship [0.03%]
儿童穿孔性阑尾炎的诊治、病原学及抗菌 stewardship
Katherine B Snyder,Catherine J Hunter,Christie L Buonpane
Katherine B Snyder
Although appendicitis has been described for more than 300 years, its optimal management remains a topic of active investigation. Acute appendicitis is the most common cause of peritonitis in children, and rates of perforated appendicitis a...