Therapeutic Strategies Targeting the Molecular Pathogenesis of Myotonic Dystrophy Type 1: Current Status and Future Directions [0.03%]
肌营养不良症1型靶向分子发病机制的治疗策略：现状与未来方向
Mohamed Chahine,Vamsi Krishna Murthy Ginjupalli,Dominic Jauvin et al.
Mohamed Chahine et al.
Myotonic dystrophy type 1 is the most prevalent adult-onset muscular dystrophy and is characterized by progressive muscle weakness, myotonia, cardiac conduction defects, endocrine dysfunction, and central nervous system involvement. Myotoni...
Yoann Leblay,Marie-Solenne Felix,Jean-Christophe Roux et al.
Yoann Leblay et al.
Rett syndrome is a rare X-linked neurodevelopmental disorder caused by mutations in MECP2, a gene critical for neuronal function, chromatin organization, and synaptic plasticity. After a period of apparently normal early development, indivi...
Beyond Binary FISH Results: Targeted NGS Provides Deeper Characterization of MYC and Broader Genomic Alterations in DLBCL [0.03%]
MYC双色FISH检测结果阴性的DLBCL患者中，目标panel测序能够进行更深入的MYC重排及更大范围内的基因组学改变检测
Mariana Bastos Oreiro,Sara Fernández de Córdoba Oñate,Ismael de la Iglesia San Sebastián et al.
Mariana Bastos Oreiro et al.
Introduction: Rearrangements involving MYC, BCL2, and BCL6 are central to the genetic classification and risk stratification of diffuse large B cell lymphoma (DLBCL). In routine practice, these alterations are primarily a...
Masahiro Okada,Satoru Yamasaki,Go R Sato et al.
Masahiro Okada et al.
Neoantigens have emerged as central targets in the development of individualized cancer vaccines, as they are recognized by the immune system as foreign and can elicit potent anti-tumor responses. Advances in computational algorithms and ma...
The Evolving Role of Genomic Technologies in Multiple Myeloma: Implications for Diagnosis, Risk Stratification and Resistance [0.03%]
基因组技术在多发性骨髓瘤中的作用及其对诊断、危险分层和耐药性的意义
Klára Baďurová,Veronika Kapustová,Jana Kotulová et al.
Klára Baďurová et al.
Plasma cell disorders range from indolent precursors to aggressive malignancies, with multiple myeloma as the most common malignant form. Multiple myeloma biology is highly complex and driven by genomic heterogeneity. Although recent genomi...
Szymon Rutecki,Krzysztof Książek,Justyna Mikuła-Pietrasik
Szymon Rutecki
Exosomes are small extracellular vesicles secreted by various cells. They play a vital role in intercellular communication due to their diverse molecular cargo. Recent advancements in biomedical research have enabled a more detailed charact...
Hannah A Blair
Hannah A Blair
Etuvetidigene autotemcel (WASKYRA™) is an autologous haematopoietic stem cell (HSC)-based gene therapy being developed by Fondazione Telethon for the treatment of Wiskott-Aldrich syndrome (WAS). In December 2025, etuvetidigene autotemcel w...
RNA Aptamers and Epitranscriptomics: Charting Unexplored Territories in RNA Biology [0.03%]
RNA适配体和表转录组学：RNA生物学中未探索领域的研究地图
Mehran Khorshid,Ehsan Pashay Ahi
Mehran Khorshid
The fields of RNA aptamers and epitranscriptomics have each emerged as powerful dimensions of RNA biology, yet their conceptual and mechanistic overlap remains largely unexplored. RNA aptamers as in vitro-selected single-stranded RNA oligon...
Pre-analytical Best Practices for RNA Sequencing from Small Biopsies and Cytologic Specimens [0.03%]
来自小型活检和细胞学标本的RNA测序的前分析最佳实践
Gloria Hopkins Sura,Kelly B Engel,Sarah R Greytak et al.
Gloria Hopkins Sura et al.
RNA sequencing is becoming increasingly common in precision oncology, in both clinical and research settings, for transcriptome profiling, gene-fusion detection, and biomarker discovery. RNA-sequencing analysis of specimens obtained via min...
Colorectal Cancer: A Landscape of New Potential Radiopharmaceuticals [0.03%]
结直肠癌放射性药物新药研发进展与思考——评《结直肠癌靶向放射性药物治疗》书籍要点
Veronica Serena Cabitza,Pier Cesare Capponi,Irene Brusa et al.
Veronica Serena Cabitza et al.
In recent years, advancements in imaging techniques have contributed to a gradual yet promising reduction in colorectal cancer-related mortality. Among these, positron emission tomography (PET), particularly in combination with computed tom...