Considering Tumour Sidedness is Critical for Accurate Interpretation of Liquid Biopsy Results in Metastatic Colorectal Cancer [0.03%]
在转移性结直肠癌中考虑肿瘤侧性对于准确解释液体活检结果至关重要
Marta Toledano-Fonseca,Icíar de la Fuente,María José Ortiz-Morales et al.
Marta Toledano-Fonseca et al.
Background: Colorectal cancer is one of the most common and deadly malignancies worldwide. Traditionally, all colon tumours have been treated as a single entity, but growing evidence shows that tumour behaviour differs ma...
Matt Shirley
Matt Shirley
Tividenofusp alfa (tividenofusp alfa-eknm; AVLAYAH™) is an intravenous brain-penetrant enzyme replacement therapy being developed by Denali Therapeutics for the treatment of mucopolysaccharidosis type II (MPS II). Also known as Hunter synd...
Jennifer Hanson,Penelope E Bonnen
Jennifer Hanson
Cerebrotendinous xanthomatosis (CTX) is rare, autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in CYP27A1, which encodes sterile 27 hydroxylase, a key enzyme in bile acid biosynthesis. Enzyme deficiency...
Standardized Analytical Verification of ctDNA ESR1 Mutation Testing in Metastatic HR+/HER2- Breast Cancer: A European Multicentre Study Using dPCR and NGS-Based Liquid Biopsy [0.03%]
欧洲多中心研究使用dPCR和基于NGS的液体活检对转移性HR+/HER2-乳腺癌中ctDNA ESR1突变检测的标准分析验证：一项欧洲多中心研究
Federico Rojo,Valentina Guarneri,Nicola Fusco et al.
Federico Rojo et al.
Introduction: Activating ESR1 mutations are a major mechanism of resistance to aromatase inhibitors in hormone receptor-positive, HER2-negative metastatic breast cancer (mBC). International guidelines, including those fro...
LINE-1 Deregulation in Ovarian Cancer: Implications for Diagnosis, Prognosis, and Therapeutic Targeting [0.03%]
卵巢癌中LINE-1逆转座子去抑制的诊断、预后和治疗靶向意义
Nicoletta Bonci,Valentina Schiavoni,Jesmina Rexha et al.
Nicoletta Bonci et al.
Ovarian cancer is a highly heterogeneous malignancy and remains a major cause of cancer-related mortality, mainly due to late diagnosis and frequent development of therapy resistance. Current diagnostic markers show limited sensitivity for ...
Targeting Cytotoxic T-Cell Effector Function with Granzyme B PET: Translational Advances Toward Predicting Immunotherapy Outcomes [0.03%]
靶向细胞毒性T细胞效应功能的颗粒酶B-PET：预测免疫治疗效果的转化进展
Luca Filippi,Priscilla Guglielmo,Esra Arslan et al.
Luca Filippi et al.
The clinical success of cancer immunotherapy has highlighted the urgent need for biomarkers capable of capturing dynamic and functional anti-tumor immune activity. Granzyme B (GzmB), a serine protease released by activated cytotoxic CD8⁺ T...
Real-Time Detection of Colorectal Cancer Using Topical Application of a pH-Activatable Fluorophore [0.03%]
一种 topical application的pH激活荧光染料结肠镜检查技术诊断结直肠癌的研究
Daan G J Linders,Jinhui Ser,Md Shamim et al.
Daan G J Linders et al.
Introduction: Standard treatment for locally advanced rectal cancer involves neoadjuvant chemoradiation therapy (nCRT) followed by total mesorectal excision, but this approach carries significant morbidity and often resul...
Extracellular Vesicles in Beta-Thalassemia: Phenotype-Specific Profiles and Potential Clinical Associations [0.03%]
β-地中海贫血的细胞外囊泡：表型特异性谱型和潜在临床相关性
Sirichai Srichairatanakool,Siriporn C Chattipakorn,Adisak Tantiworawit et al.
Sirichai Srichairatanakool et al.
Βeta-thalassemia is one of the most common genetic disorders worldwide, characterized by ineffective erythropoiesis (IE), which leads to a wide spectrum of heterogeneous disease-related complications. Extracellular vesicles (EVs) have emer...
Correction: Beyond Binary FISH Results: Targeted NGS Provides Deeper Characterization of MYC and Broader Genomic Alterations in DLBCL [0.03%]
关于FISH二元结果的更正：靶向NGS对DLBCL中MYC进行更为深入的表征并揭示了更为广泛的基因组改变
Mariana Bastos-Oreiro,Sara Fernández de Córdoba-Oñate,Ismael de la Iglesia-San Sebastián et al.
Mariana Bastos-Oreiro et al.
Published Erratum
Molecular diagnosis & therapy. 2026 May 22. DOI:10.1007/s40291-026-00857-2 2026
Heat Shock Proteins as Cancer Biomarkers: From Mechanism to Clinical Application [0.03%]
热休克蛋白作为癌症生物标志物：从机制到临床应用
Prajjwal Kushwaha,Ipsita Roy
Prajjwal Kushwaha
Molecular chaperones are an integral part of the proteostasis network of the cell that regulate client protein folding, substrate interactions, disaggregation, degradation, and intracellular trafficking, either independently or through coor...