Effectiveness of Sacubitril/Valsartan in Reducing Hospitalizations in Older Belgian Adults with Heart Failure and Reduced Ejection Fraction: An Age-Stratified Study [0.03%]
索卡布トリ尔/瓦尔沙塔ン用于减少老年比利时成人射血分数降低的心力衰竭住院的有效性：分年龄段研究
Eléonore Maury,Lorenz Van der Linden,Kris Bogaerts et al.
Eléonore Maury et al.
Background: Heart failure with reduced ejection fraction is increasingly prevalent in older adults, yet data on guideline-directed therapies in the oldest age groups remain limited. ...
Cross-Sectional Study on Factors Associated with Hyperpolypharmacy and Medication Adherence in Older Adults with Multimorbidity and Polypharmacy [0.03%]
多病共存和多重用药老年高血压患者高药物负苛及服药依从性的横断面研究
Shanthi Beglinger,Lisa Bretagne,François Volery et al.
Shanthi Beglinger et al.
Background: Knowledge of multiple medication use and medication adherence is important to assess treatment effectiveness and prevent worsening of disease, re-hospitalization, and increased healthcare costs. Limited data e...
Effectiveness of a Collaborative Deprescribing Intervention of Proton Pump Inhibitors on Community-Dwelling Older Adults: The C-SENIoR Pragmatic Non-randomised Controlled Trial [0.03%]
一项在社区居住的老年人中联合减药干预抑制质子泵的有效性非随机对照试验(C-SENIoR实际研究)
Sónia Romano,António Teixeira Rodrigues,José Pedro Guerreiro et al.
Sónia Romano et al.
Background: Proton pump inhibitors (PPIs) are commonly used and often prescribed inappropriately, which increases the risk of adverse events. Deprescribing is a health professional-supervised intervention aimed at reducin...
Diana I Brixner,Chenyue Zhao,Hideki Toyosaki et al.
Diana I Brixner et al.
Background: Lecanemab is the first anti-amyloid monoclonal antibody with full approval in the US for the treatment of early Alzheimer's disease (AD). This observational study aimed to provide information about patient dem...
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward [0.03%]
老年患者在癌症早期临床试验中的纳入：安全性、有效性和未来方向
Jessie Nguyen,Nicolò Matteo Luca Battisti,Danielle Ní Chróinín et al.
Jessie Nguyen et al.
Early-phase clinical trials (EPCTs) are critical for evaluating the safety, tolerability, efficacy and pharmacokinetics of novel oncology therapies. However, older adults are underrepresented in all phases of oncology clinical trials, inclu...
Menopause, Hormone Therapy, and Gout in Older Women: An Overlooked Connection : A Comment on "Comparison of Clinical Characteristics in Older-Onset and Common-Age-of-Onset Gout: A Prospective Gout Cohort Study" by Do et al [0.03%]
关于绝经、激素治疗与高尿酸血症的关系——冷门但不应被忽视的一环：对Do等“不同年龄期痛风患者的临床特点比较：前瞻性队列研究”一文的述评
Anna Vittoria Mattioli
Anna Vittoria Mattioli
The FORTA (Fit for the Aged) List 2024: Fifth Version of a Validated Clinical Aid for Improved Pharmacotherapy in Older Adults [0.03%]
2024年FORTA（适合老年人）清单第五版：改善老年患者药物治疗的临床辅助工具的有效版本
Farhad Pazan,Christel Weiss,Martin Wehling;FORTA
Farhad Pazan
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic [0.03%]
老年门诊病人使用加巴喷丁类药物的趋势及用药规律性：一项跌倒诊所回顾性横断面研究
Hussein Alkafaji,Jesper Schmidt,Johannes Riis et al.
Hussein Alkafaji et al.
Purpose: With pain treatment shifting away from opioids, alternative analgesics-such as gabapentinoids-are increasingly being used. This study investigated the prevalence and indications for gabapentinoid use among geriat...
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial [0.03%]
面向患者的教育促进停用药物的实效性研究——一项实用主义试验
Katie Fitzgerald Jones,Kelly Stolzmann,Jolie Wormwood et al.
Katie Fitzgerald Jones et al.
Background: More than one in three older adults use potentially inappropriate medications (PIMs), and those with chronic conditions are more likely to be on multiple PIMs. Deprescribing, defined as stopping or dose-reduci...