Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies [0.03%]
老年肿瘤患者肌少症和恶病质的病理生理、诊断、对预后的影响及处理策略
Efthymios Papadopoulos,Brian A Irving,Justin C Brown et al.
Efthymios Papadopoulos et al.
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on ...
Amyloid-related Imaging Abnormalities (ARIA) in the Context of Alzheimer's Disease and Amyloid-targeting Therapies: An Introduction for Advanced Practice Providers [0.03%]
阿尔茨海默病及相关淀粉样蛋白靶向治疗中的影像异常（ARIAs）——为高级实践提供者介绍
Curtis P Schreiber,Amy Kovacik,James Bishop et al.
Curtis P Schreiber et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder pathologically characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles of hyperphosphorylated tau in the brain. Amyloid-targeting therapies (AT...
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study [0.03%]
抗精神病药物剂量与住院老年人疗效和安全性替代指标之间的关联：一项回顾性队列研究
Nicole M Sarisky,Collin M Clark,Stephanie Seyse et al.
Nicole M Sarisky et al.
Introduction: Antipsychotics are frequently used in hospitalized older adults to manage agitation and delirium, despite limited supporting evidence and known risks. While guidelines recommend low doses and short durations...
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke [0.03%]
急性缺血性卒中急诊机械取栓的老年人麻醉注意事项
Byrappa Vinay,Nitin Manohara,Amit Jain
Byrappa Vinay
Acute ischemic stroke (AIS) is a significant cause of morbidity and mortality among older adults, with its incidence, severity, and complication rates increasing with age. Endovascular thrombectomy (EVT) is the standard treatment for AIS du...
Sacubitril/Valsartan, Heart Failure and Risk of Dementia [0.03%]
心力衰竭伴血管紧张素受体-脑啡肽酶抑制剂治疗与以后发生痴呆症的风险：一项回顾性队列研究
Antoine Garnier-Crussard,Virginie Dauphinot,Christelle Mouchoux et al.
Antoine Garnier-Crussard et al.
Editorial
Drugs & aging. 2025 Sep 16. DOI:10.1007/s40266-025-01242-0 2025
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges [0.03%]
狼疮晚发的临床特点、诊断及治疗挑战
Natsuki Sakurai,Ryusuke Yoshimi,Hideaki Nakajima
Natsuki Sakurai
Systemic lupus erythematosus (SLE) is widely recognized as a systemic autoimmune disease predominantly affecting young women. However, since the initial report in 1959, cases of late-onset SLE have been increasingly documented. Late-onset S...
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis [0.03%]
老年≥80岁患者减剂量艾多沙班临床疗效及安全性的真实世界研究
Ruiqi Zhang,Jiali Du,Meilin Liu
Ruiqi Zhang
Background: Optimal anticoagulation strategies in octogenarians remain controversial owing to age-related risks of thromboembolism and bleeding. This study evaluates real-world outcomes of reduced-dose edoxaban (15-30 mg ...
Medication Non-adherence in Older Adults: Underlying Factors, Potential Interventions and Outcomes [0.03%]
老年人用药不合规：潜在影响因素、干预手段及后果分析
Elstin Anbu Raj Stanly,Rajesh Vilakkathala,Johnson George
Elstin Anbu Raj Stanly
Polypharmacy is very common among older adults and is associated with poor health outcomes. This scoping review aimed to understand the underlying factors for poor medication taking by older patients and potential solutions to mitigate thes...
Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia [0.03%]
利用药物分发数据识别具有相似处方模式的老年痴呆症患者群簇
Abby Emdin,Therese A Stukel,Jennifer Bethell et al.
Abby Emdin et al.
Background and objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that...
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population [0.03%]
糖尿病老年人低血糖：老龄化人群的发病机制、预防和个性化治疗
Virginia Boccardi,Alan J Sinclair
Virginia Boccardi
Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to which this population is particularly vulnerable owing to frailty, multimorbidity and cognitive decline. Guidelines re...