Developing a Hierarchical Algorithm to Identify Pregnancies and Determine Gestational Age from Nationwide Linked Health Data in Taiwan [0.03%]
开发分层算法，从台湾全国链接卫生数据中识别妊娠并确定孕周
Miyuki Hsing-Chun Hsieh,Zoe Chi-Jui Chang,Chih-Wan Lin et al.
Miyuki Hsing-Chun Hsieh et al.
Background: Administrative health data are vital for investigating medication safety during pregnancy. In Taiwan, while the National Health Insurance Research Database (NHIRD) and Birth Certificate Application (BCA) captu...
Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis [0.03%]
口服抗凝剂与低分子量肝素在肿瘤相关血栓形成治疗中的有效性和安全性：系统性回顾和meta分析
Wei Kang,Bowie P Y Lam,Rinko Tsz Lam Lau et al.
Wei Kang et al.
Background: Cancer-associated thrombosis is a condition associated with high mortality rates, yet limited evidence exists regarding the safety and effectiveness of low-molecular-weight heparin (LMWH) and direct oral antic...
Analytic Misjudgment of Drug Safety Evidence and Causality: From the Prosecutor's Fallacy and Simpson's Paradox to Artificial Intelligence [0.03%]
药物安全证据和因果关系的分析误判：从检察官谬论和辛普森悖论到人工智能
Tarek A Hammad,Justine Rochon
Tarek A Hammad
Drug safety assessment, particularly in the post-marketing setting, is especially vulnerable to analytic misjudgment because it relies on heterogeneous evidence streams, incomplete data, infrequent events, and decisions made under substanti...
A Large Language Model for Extracting Post-marketing Adverse Drug Events from Clinical Notes in the Electronic Health Record [0.03%]
一种从电子健康记录的临床笔记中提取药品上市后不良事件的大型语言模型
Dana Ludwig,Michelle Wang,James Buchanan et al.
Dana Ludwig et al.
Background: Clinical notes contain a vast amount of potentially useful information about adverse drug event (ADE) signals that never reach pharmacovigilance databases. Traditional rule-based or sentence-level models often...
Assessing the Risk of Adverse Maternal and Infant Outcomes Following Prenatal Modafinil Exposure: A French Nationwide Cohort Study [0.03%]
孕期莫达菲尼暴露对母婴不良结局的风险评估：一项法国全国队列研究
Sigal Kaplan,Julie de Nascimento,Andrea Contini
Sigal Kaplan
Background and objectives: Concerns about modafinil and armodafinil use in pregnancy emerged from animal reproductive toxicity and limited human data, including a US registry suggesting increased risk of major congenital ...
Gabapentin and Pregabalin Use in First Trimester of Pregnancy and Risk of Specific Congenital Anomalies: An IMI ConcePTION European Case-Malformed Control Study [0.03%]
妊娠早期使用加巴喷丁和普瑞巴林与特定先天性畸形风险的关系：IMI ConcePTION欧洲病例对照研究
Anna-Belle Beau,Erika Cifuentes Castro,Justine Benevent et al.
Anna-Belle Beau et al.
Introduction and objective: Given the increasing use of gabapentinoids and ongoing safety concerns, we assessed the association between first-trimester exposure to gabapentin and pregabalin and the risk of specific congen...
Global Perspective on the Evolution and Future of Pharmacovigilance: Deliverables from the 24th Annual Meeting of the International Society of Pharmacovigilance Celebrating 25 Years of Excellence [0.03%]
全球视角下的药物警戒演化和未来：国际药物警戒协会第24届年会成果报告（庆祝卓越成就25周年）
Mohamed A Elhawary,Brian Edwards,Hadir Rostom et al.
Mohamed A Elhawary et al.
Editorial
Drug safety. 2026 Jun 2. DOI:10.1007/s40264-026-01680-8 2026
Incidence of Naloxone-Use Before and After Implementing Opioid Safety Measures for Patients Hospitalised on General Wards in a Swiss University Hospital [0.03%]
瑞士大学医院实施阿片类药物安全措施前后普通病房住院患者纳洛酮使用率的研究
Anja Jungo,Kanchan Dongre,Delia Halbeisen et al.
Anja Jungo et al.
Background: Opioids are high-risk medications that in overdose can lead to severe life-threatening or fatal adverse drug events. Inadvertent overdose is often the cause of opioid intoxication in hospitals. We introduced d...
Theoretical Framework and Key Considerations for Time-to-Onset Analysis in Spontaneous Reporting Systems [0.03%]
自发报告系统中时间序贯分析理论框架及关键考量因素研究
Yoshihiro Noguchi,Yoko Ino,Satoshi Yokoyama et al.
Yoshihiro Noguchi et al.
Spontaneous reporting databases play a central role in pharmacovigilance for monitoring the safety of drugs and vaccines. Conventional statistical signal detection has relied primarily on disproportionality analyses based on reporting frequ...
Assessing Natural Health Product-Drug Interactions and Coding Feasibility: Analysis of a New Zealand General Population Dataset from an Online Market Research Panel [0.03%]
新西兰通用人群数据集的在线市场研究面板中的天然健康产品与药物相互作用及编码可行性分析
E Lyn Lee,Fraser Ogle,Jyadeep Nagra et al.
E Lyn Lee et al.
Introduction: Natural health products (NHPs) include complementary/alternative medicines, dietary supplements, nutraceuticals, and traditional medicines. Natural health products are often self-prescribed and used alongsid...