Impact of Psilocybin on Motor Function in Healthy Participants: A Phase 1, Randomised, Triple-Blind, Dose-Finding Study [0.03%]
裸盖菇素对健康受试者运动功能的影响：一项随机、三盲、剂量寻找的1期研究
Chiranth Bhagavan,Olivia Carter,Glenn Nielsen et al.
Chiranth Bhagavan et al.
Background: Psychedelics exert widespread effects on brain activity, but their impact on motor function is unclear. This is clinically relevant given the emerging interest in psychedelic-assisted physical therapy for diso...
Sigma-1 Receptor Ligand Blarcamesine (ANAVEX 2-73) for Alzheimer's Disease: A Systematic Review [0.03%]
治疗阿尔茨海默病的sigma-1受体配体blarcamesine（anavex 2-73）：系统性综述
Sirikalaya Brimson,Premrutai Thitilertdecha,Kishoree Krishna Kumaree et al.
Sirikalaya Brimson et al.
Background and objectives: Alzheimer's disease (AD) remains a major cause of dementia, and currently available therapies provide only modest clinical benefit or are limited by intravenous administration and treatment-rela...
Efficacy and Safety of an Early Aggressive Lipid-Lowering Strategy Using Triple Therapy After Mechanical Thrombectomy [0.03%]
机械取栓后的三联强化降脂治疗的有效性和安全性
Ho Geol Woo,Jaeyu Park,Tae-Jin Song et al.
Ho Geol Woo et al.
Background: Current guidelines recommend initial high-intensity statin monotherapy and "the wait and watch paradigm," even in patients with acute ischemic stroke (AIS). However, newer lipid-lowering therapies allow aggres...
PDE10A Inhibition in Schizophrenia: A Randomised, Placebo-Controlled Phase 2 Study of Alofropodect (CPL'36) in Patients Experiencing Acute Schizophrenia [0.03%]
精神分裂症PDE10A抑制研究：在急性期精神分裂症患者中进行的安慰剂对照II期临床试验（Alofopodect[CPL'36]）
Maciej Wieczorek,Napoleon Waszkiewicz,Ewa Gromniak-Haniecka et al.
Maciej Wieczorek et al.
Background: Drugs that inhibit phosphodiesterase 10A (PDE10A) activity have shown efficacy in animal models. However, clinical trials of PDE10A inhibitors in patients with schizophrenia have failed to provide clinically s...
Adjunctive Pharmacotherapy for Major Depressive Disorder with Anxiety Symptoms: from Monoamines to Recent Clinical Evidence [0.03%]
抑郁症伴焦虑症状的增效治疗：从单胺到临床依据
Roger S McIntyre,Masaki Kato,Michael E Thase et al.
Roger S McIntyre et al.
Anxiety symptoms are common in patients with major depressive disorder (MDD). The presence of anxiety symptoms can indicate greater depression severity, and is associated with a higher comorbidity burden, suicidality, lower levels of functi...
Comparative Bioavailability of Trimodal (CTx-1301) Versus Bimodal Dexmethylphenidate Modified-Release Formulations in Adults with Attention-Deficit/Hyperactivity Disorder: A Randomized, Single-Dose, Crossover Study [0.03%]
一项随机、单次给药、交叉试验：在注意缺陷多动障碍成人患者中，三相CTx-1301与二相盐酸右甲苯丙胺缓释制剂的生物利用度比较研究
Arthur B Straughn,Raul Silva,Michael J Cattaneo et al.
Arthur B Straughn et al.
Background and objectives: Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder that often requires sustained symptom control throughout the day. Although bimodal extended-release dexme...
Recent Locoregional CAR T-Cell Trials for the Treatment of Recurrent Glioblastoma: Implications for Neuro-Oncology Practice [0.03%]
复发性胶质母细胞瘤的局部区域CAR-T细胞试验对神经肿瘤学实践的意义
Manina Maja Etter,Kevin Akeret,Raphael Guzman et al.
Manina Maja Etter et al.
Glioblastoma remains one of the most aggressive primary brain tumors in adults, with a survival rarely exceeding 15 months despite multimodal therapy. Novel immunotherapeutic strategies, particularly chimeric antigen receptor T-cell therapy...
Memantine Augmentation in Obsessive-Compulsive Disorder: A Systematic Review and Meta-analysis [0.03%]
氯胺酮联合治疗强迫症的系统综述和meta分析
Stanley Lyndon,Donald R McNally
Stanley Lyndon
Background: Obsessive-compulsive disorder (OCD) remains challenging to treat despite established treatments. Objective: Since glutamate...
Sublingual Administration for Pain Control: Pharmacology, Clinical Applications and Future Directions [0.03%]
舌下给药镇痛：药理学、临床应用及未来方向
Sarang S Koushik,Karina Gritsenko,Dhanesh D Binda et al.
Sarang S Koushik et al.
Sublingual (SL) drug delivery represents an important alternative route of analgesic administration, particularly in settings where rapid pain control is desired or oral and parenteral routes are limited. By enabling direct absorption throu...
Disease Stabilization with MEK Inhibitors in NF1-Associated Plexiform Neurofibromas: A Systematic Review and Meta-Analysis with Subgroup Analyses by Age and Study Design [0.03%]
NF1相关性丛状神经纤维瘤使用MEK抑制剂达到疾病稳定的系统评价和元分析及分年龄、研究设计的亚组分析
Sai Sanikommu,Alejandro N Santos,Bashar M Dawoud et al.
Sai Sanikommu et al.
Background: Plexiform neurofibromas (PN) represent a significant cause of morbidity among patients diagnosed with neurofibromatosis type 1 (NF1). MEK inhibitors continue to be developed as targeted therapies by inhibiting...