Pharmacokinetics and Safety of Navitoclax in Hepatic Impairment [0.03%]
肝损伤患者中Navitoclax的药代动力学和安全性研究
Maulik Patel,Jalaja Potluri,Thomas Marbury et al.
Maulik Patel et al.
Background and objective: Navitoclax, an orally bioavailable B-cell lymphoma-2 (Bcl-2) family protein inhibitor, inhibits antiapoptotic Bcl-2 family proteins (with high affinity to Bcl-XL, Bcl-2, and Bcl-W). Navitoclax in...
Cosmin Balan,Cristian Boros,Serban-Ion Bubenek-Turconi et al.
Cosmin Balan et al.
Objectives: The volume kinetics of a commercially available colloid fluid, Gelofusine, have not been studied previously. Methods: Intra...
Leveraging Clinical Data to Enhance the Performance Evaluation of Ceftriaxone Population Pharmacokinetic Models in Children [0.03%]
利用临床数据提高儿童头孢曲松人群药动学模型性能评估水平
Stef Schouwenburg,Tim Preijers,Alan Abdulla et al.
Stef Schouwenburg et al.
Introduction: Sepsis affects approximately 8% of pediatric intensive care unit (PICU) admissions in high-income countries. Ceftriaxone, a broad-spectrum beta-lactam antibiotic, is widely used for treating severe infection...
Correction: Influence of Ageing on the Pharmacodynamics and Pharmacokinetics of Chronically Administered Medicines in Geriatric Patients: A Review [0.03%]
校正：年龄对慢性给药药物在老年患者体内药理作用和药代动力学的影响：一项回顾性研究
Nokwanda N Ngcobo
Nokwanda N Ngcobo
Published Erratum
Clinical pharmacokinetics. 2025 Mar 15. DOI:10.1007/s40262-025-01494-4 2025
Pharmacokinetics and Target Attainment of Teicoplanin: A Systematic Review [0.03%]
替考拉宁的药代动力学和目标覆盖率：系统评价
Jaap W A Mouton,Arnaud De Clercq,Peter De Paepe et al.
Jaap W A Mouton et al.
Background and objective: Teicoplanin is a glycopeptide antibiotic used to treat severe Gram-positive infections. This systematic review provides a comprehensive overview of the current knowledge on the pharmacokinetics o...
Evaluation of Safety and Pharmacokinetics of DDCI-01, a Phosphodiesterase Type 5 Inhibitor, in Healthy Participants [0.03%]
DDCI-01（一种磷酸二酯酶型5抑制剂）在健康受试者中的安全性和药代动力学评价
Qian Li,Shen-Shen Huang,Dong-Chuan Zhang et al.
Qian Li et al.
Aim: The aim of this study was to evaluate the safety, tolerability, and pharmacokinetics of single escalating oral doses of DDCI-01 (a novel, highly selective, long-acting phosphodiesterase type 5 inhibitor) administered...
Opportunities for Precision Dosing of Cytotoxic Drugs in Non-Small Cell Lung Cancer: Bridging the Gap in Precision Medicine [0.03%]
非小细胞肺癌细胞毒药物精准给药的机遇：弥合精准医学领域的差距
M P Kicken,M J Deenen,A J van der Wekken et al.
M P Kicken et al.
Precision dosing of classical cytotoxic drugs in oncology remains underdeveloped, especially in treating non-small cell lung cancer (NSCLC). Despite advancements in targeted therapy and immunotherapy, classical cytotoxic agents continue to ...
Ticagrelor is Associated with Increased Rosuvastatin Blood Concentrations in Patients who have had a Myocardial Infarction [0.03%]
Ticagrelor与心肌梗死后患者rosuvastatin血浓度升高有关
Tjaša Dermota,Borut Jug,Jurij Trontelj et al.
Tjaša Dermota et al.
Aims: The primary objective of this study was to determine whether concomitant therapy with ticagrelor and rosuvastatin affects rosuvastatin plasma concentrations in patients receiving rosuvastatin 40 mg/day after myocard...
Pharmacokinetics of Opioid Infusions in the Adult Intensive Care Unit Setting-A Systematic Review [0.03%]
成人重症监护病房中阿片类药物输注的药代动力学-系统回顾
Johannie Beaucage-Charron,Justine Rinfret,Guillaume Trottier et al.
Johannie Beaucage-Charron et al.
Introduction: Pharmacokinetics (PKs) of drugs are often altered in the intensive care unit (ICU). Opioids are often used in the ICU, particularly as continuous infusions, and their characteristics lead them to undergo PK ...
Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing [0.03%]
头孢吡肟在危重儿童和年轻成人中的群体药动学：模型建立以及用于蒙特卡洛模拟和基于模型的精准给药的外部验证
Ronaldo Morales Junior,H Rhodes Hambrick,Tomoyuki Mizuno et al.
Ronaldo Morales Junior et al.
Background and objective: This study aimed to develop a population pharmacokinetic model for cefepime in critically ill pediatric and young adult patients to inform dosing recommendations and to evaluate the model's predi...