Variability in Meropenem Distribution and Clearance in Children with Sepsis: Population-Based Pharmacokinetics with Assessment of Renal Biomarkers [0.03%]
重症感染儿童美罗培南药动学的个体差异及人群模型结合肾功能标志物评估
Jennifer Le,Julie Huynh,Brandon Vo et al.
Jennifer Le et al.
Background and objective: Meropenem dosing to achieve therapeutic exposure in critically ill children with sepsis is challenging due to a spectrum of renal function, from augmented renal clearance (ARC) to acute kidney in...
Population Pharmacokinetics and Pharmacodynamics of Fepixnebart (LY3016859) and Epiregulin in Patients with Chronic Pain [0.03%]
慢性疼痛患者中Fepixnebart（LY3016859）和Epiregulin的群体药代动力学和药效学研究
Douglas E James,Jason Bailey,Jan-Stefan van der Walt et al.
Douglas E James et al.
Background and objective: Fepixnebart (LY3016859), a humanized immunoglobulin G4 monoclonal antibody with high binding affinity to epiregulin and tumor growth factor-α, is being developed as a novel analgesic to treat br...
Model-Informed Dose Optimization of Pazopanib in Real-World Patients with Cancer [0.03%]
基于模型的帕唑帕尼剂量优化在癌症患者中的应用研究
Zhiyuan Tan,Swantje Völler,Anyue Yin et al.
Zhiyuan Tan et al.
Background and objectives: Pazopanib is approved for metastatic renal cell carcinoma (mRCC) and soft tissue sarcoma (STS) in a dose of 800 mg once daily (QD) taken under fasted conditions. In clinical practice, approximat...
Population Pharmacokinetics of Tarlatamab, a Half-Life Extended DLL3-Directed Bispecific T-Cell Engager in Patients with Previously Treated Small Cell Lung Cancer [0.03%]
Tarlatamab的群体药代动力学：一种半衰期延长的DLL3导向双特异性T细胞接合器在既往接受过治疗的小细胞肺癌患者中的应用
Stephanie Kong,Mukul Minocha,Po-Wei Chen et al.
Stephanie Kong et al.
Background and objective: Tarlatamab is a first in class, half-life extended delta-like ligand 3 (DLL3) directed bispecific T-cell engager (BiTE®) immunotherapy that has shown durable efficacy in patients with previously...
Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19 [0.03%]
新冠肺炎住院患者的瑞德西韦及其代谢产物GS-441524群体药代动力学模型研究
Darren M Roberts,Xin Liu,Suzanne L Parker et al.
Darren M Roberts et al.
Background and objectives: There are limited data testing whether the licensed dose of remdesivir and its active metabolite GS-441524 achieve target concentrations in hospitalised patients with confirmed severe acute resp...
Anti-infectives in Pediatric Patients with Cystic Fibrosis: A Comprehensive Review of Population Pharmacokinetic Analyses [0.03%]
囊性纤维化患儿的抗感染药物药代动力学综合评价
Aysenur Yaliniz,Mehdi El Hassani,Ana C Blanchard et al.
Aysenur Yaliniz et al.
Pulmonary complications are the leading cause of morbidity and mortality in pediatric patients with cystic fibrosis. Altered pharmacokinetic parameters in this population, as well as high inter- and intra-individual variability, complicate ...
Pharmacokinetics and Pharmacodynamics of Prusogliptin (DBPR108), a Once-Daily Dipeptidyl Peptidase-4 Inhibitor, in Patients with Type 2 Diabetes [0.03%]
普鲁格列酮(DBPR108)的药代动力学和药效学：一种每日一次的二肽基肽酶-4抑制剂用于治疗2型糖尿病患者的临床研究
Wenfang Liu,Kexu Yang,Yang Lin et al.
Wenfang Liu et al.
Background and objective: DBPR108 (prusogliptin) is a novel, orally bioavailable dipeptidyl peptidase-4 (DPP-4) inhibitor. This study investigated the pharmacokinetics and pharmacodynamic characteristics of DBPR108 tablet...
A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations [0.03%]
关于环丙沙星和多黏菌素B成人药代动力学研究的系统评价
Puteri Juanita Zamri,Sazlyna Mohd Sazlly Lim,Fekade Bruck Sime et al.
Puteri Juanita Zamri et al.
Background and objective: The pharmacokinetics of polymyxins are highly variable and conventional dosing regimens may likely lead to sub-optimal exposures and outcomes, particularly in critically ill patients with multi-d...
Impact of Hypothermic Temperature Control on Plasma and Soft Tissue Pharmacokinetics of Penicillin/Beta-Lactamase Inhibitor Combinations in Patients Resuscitated After Cardiac Arrest [0.03%]
心肺复苏术后心脏骤停患者低温管理对青霉素/β-内酰胺酶抑制剂复合制剂血浆及软组织药动学的影响
Alexandra-Maria Stommel,Peter Matzneller,Valentin Al Jalali et al.
Alexandra-Maria Stommel et al.
Background and objectives: Penicillin/beta-lactamase inhibitors are often used to treat aspiration pneumonia in patients resuscitated after cardiac arrest (CA). The impact of hypothermic temperature control on the pharmac...
Pharmacokinetics and Safety of Levofloxacin for Treatment of Rifampicin-Resistant Tuberculosis During Pregnancy and the Postpartum Period: Results from IMPAACT P1026s [0.03%]
妊娠和产后期间利福平耐药结核病治疗中左氧氟沙星的药代动力学和安全性：来自IMPAACT P1026s的研究结果
Jennifer A Hughes,Mauricio Pinilla,Kristina M Brooks et al.
Jennifer A Hughes et al.
Background and objective: Treatment of rifampicin-resistant tuberculosis (RR-TB) often includes fluoroquinolones, but data on long-term exposure during and after pregnancy are limited. We examined the pharmacokinetics and...