Population Pharmacokinetic and Pharmacodynamic Modeling to Support Molar Dose Ratio Determination of Long-Acting Insulin Analogs [0.03%]
基于人群的药动学和药效学模型支持低分子量胰岛素类似物剂量比确定的研究
Dan Tang,Xuehu Gao,Min Zhu et al.
Dan Tang et al.
Background and objective: INS068 is a new soluble, long-acting insulin analog intended to cover basal insulin requirements in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). The purpose ...
Population Pharmacokinetics of Intravenous Cefuroxime in Plasma and Bone of Patients with Prosthetic Joint Infection: Is There Room for Dose Optimization? [0.03%]
静脉注射头孢呋辛在人工关节感染患者血浆和骨中的药代动力学：有剂量优化的空间吗？
Gerbert Coen de Waard,Qiaolin Zhao,Ewout S Veltman et al.
Gerbert Coen de Waard et al.
Background and objective: Prosthetic joint infections are serious infections that require perioperative antibiotic prophylaxis. Cefuroxime may be used as prophylaxis, and this study aims to evaluate the current dosing reg...
A Pharmacokinetic Analysis of Intravenous Fluconazole in Adult Patients Undergoing Mechanical Circulatory Support Device Implantation [0.03%]
连续静脉注射氟康唑在植入机械循环支持装置成年患者中的药代动力学分析
Kelly A Cairns,Maria Patricia Hernandez-Mitre,Trisha N Peel et al.
Kelly A Cairns et al.
Background and objective: There is limited information on the pharmacokinetics and optimal dosing of fluconazole in patients undergoing mechanical circulatory support (MCS) device implantation. ...
Pharmacokinetic-Pharmacodynamic Modeling and Simulation of Merigolix, a Nonpeptide Gonadotropin-Releasing Hormone Antagonist [0.03%]
口服GnRH拮抗剂米他司酮的药动学和药效学模型及模拟研究
Soo Hyeon Bae,Jueun Kang,Sangil Jeon et al.
Soo Hyeon Bae et al.
Gonadotropin-releasing hormone (GnRH) antagonists inhibit estrogen synthesis and secretion, making them promising treatment options for estrogen-dependent diseases, such as endometriosis. This study developed a population pharmacokinetic/ph...
Development and Validation of a Chinese Obesity-Specific Physiological Database for PBPK Modeling [0.03%]
中国肥胖人群生理参数数据库的建立与验证
Ruwei Yang,Yujie Wen,Shengnan Zhang et al.
Ruwei Yang et al.
Objectives: To develop and validate a physiologically based pharmacokinetic (PBPK) population model for the Chinese obese population. Methods: ...
Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules [0.03%]
一种评估GalNAcıRNA分子平台集中度-QTc关系的方法
Prajakta Badri,Kiranmai Kolachana,Anh Duong et al.
Prajakta Badri et al.
Background: GalNAc-conjugated short interfering RNAs (GalNAc-siRNAs) lack a biologically plausible mechanism for QT/QTc prolongation based on their unique physicochemical and absorption, distribution, metabolism, and excr...
Antibacterial Pharmacokinetics in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation (ECMO): A Systematic Review of Population Pharmacokinetic Studies [0.03%]
体外膜肺氧合患者抗菌药物药代动力学的系统评价：人口药代动力学研究
Chanelle Ren,Frank Huang,Vesa Cheng et al.
Chanelle Ren et al.
Background and objective: Achieving optimal antibacterial dosing in critically ill patients is challenging owing to the pathophysiological changes that alter drug pharmacokinetics. Extracorporeal membrane oxygenation (ECM...
Population Pharmacokinetics of Total and Protein-Unbound Prednisolone in Children with Immune-Mediated and Systemic Inflammatory Diseases [0.03%]
儿科免疫介导性疾病和系统性炎症疾病患者的 prednisolone 及非结合型 prednisolone 药代动力学研究
Julia E Möhlmann,Caroline A Lindemans,Marc H A Jansen et al.
Julia E Möhlmann et al.
Background and objective: High-dose systemic prednisolone is the mainstay treatment of children with various (auto)immune diseases. The standard empirical dosing regimen with dosages up to 2 mg/kg/day is generally adequat...
Pharmacokinetics and Target Attainment of Fluoroquinolones in Older Adults: A Systematic Review [0.03%]
氟喹诺酮类药物在老年人中的药代动力学和靶标覆盖率：系统评价
Arnaud De Clercq,Jeroen Vervalcke,Cristina De Petter et al.
Arnaud De Clercq et al.
Background and objective: Fluoroquinolones are among the most frequently prescribed antibiotics in older adults. Age-related pharmacokinetic (PK) changes can affect treatment efficacy and increase the risk of adverse drug...
Guidance for External Evaluation and Selection of Population Pharmacokinetic Models for Precision Dosing [0.03%]
精准给药的群体药代动力学模型外部评估和选择指导意见
Mehdi El Hassani,Amélie Marsot
Mehdi El Hassani
Model-informed precision dosing relies on population pharmacokinetic models to personalize drug therapy and improve clinical outcomes. While hundreds of models are published, only a small fraction are externally evaluated and even fewer are...