A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly [0.03%]
哌拉西林他唑巴坦在不同患者人群中的汇总药代动力学分析：从早产儿至老年人群
Daming Kong,Jason A Roberts,Jeffrey Lipman et al.
Daming Kong et al.
Background and objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the...
Dose Optimization of Vancomycin in Pediatric Post-Cardiac Surgery Patients: A Population Pharmacokinetic Modeling Study [0.03%]
儿科心脏手术后万古霉素的剂量优化：人群药代动力学模型研究
J Kamp,D J E Wannet,E P Buddingh et al.
J Kamp et al.
Background and objective: Vancomycin is a glycopeptide antibiotic used for the treatment of severe gram-positive infections. Despite decades of clinical experience, optimized dosing for vancomycin in pediatric populations...
Population Pharmacokinetics of Epcoritamab Following Subcutaneous Administration in Relapsed or Refractory B Cell Non-Hodgkin Lymphoma [0.03%]
皮下注射Epcoritamab治疗复发或难治性B细胞非霍奇金淋巴瘤的群体药代动力学分析
Tommy Li,Leonid Gibiansky,Apurvasena Parikh et al.
Tommy Li et al.
Background and objectives: Epcoritamab is a CD3xCD20 bispecific antibody approved for the treatment of adults with different types of relapsed or refractory (R/R) B cell non-Hodgkin lymphoma (B-NHL) after ≥ 2 lines of sy...
Echinocandins Pharmacokinetics: A Comprehensive Review of Micafungin, Caspofungin, Anidulafungin, and Rezafungin Population Pharmacokinetic Models and Dose Optimization in Special Populations [0.03%]
棘白菌素类药物的药代动力学：米卡芬净、卡泊芬净、阿尼芬净和rezafungin人群药代动力学模型及特殊人群中剂量优化的综合评价
Marta Albanell-Fernández
Marta Albanell-Fernández
In recent years, many population pharmacokinetic (popPK) models have been developed for echinocandins to better understand the pharmacokinetics (PK) of these antifungals. This comprehensive review aimed to summarize popPK models of echinoca...
Evaluation of the Effect of Risankizumab on the Pharmacokinetics of Cytochrome P450 Substrates in Patients with Moderately to Severely Active Ulcerative Colitis or Crohn's Disease [0.03%]
评估瑞沙珠单抗对中至重度活动性溃疡性结肠炎或克罗恩病患者细胞色素P450底物药代动力学的影响：一项药物相互作用研究
Ronilda D&#x;Cunha,Tofial Azam,Jasmina Kalabic et al.
Ronilda D&#x;Cunha et al.
Background and objective: The objective of this study was to characterize the effects of risankizumab on the pharmacokinetics of cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A substrates in patients with mo...
Relative Forgiveness of Different Allopurinol Implementation Patterns in People with Gout and their Impact on Clinical Outcomes: a Simulation Study [0.03%]
不同别嘌醇实施方案对临床结局影响的相对宽容度——一项模拟研究
Melanie White-Koning,Daniel F B Wright,Dyfrig A Hughes et al.
Melanie White-Koning et al.
Background and objective: Adherence to urate-lowering therapy among people with gout is poor, so it is important to understand which day-to-day medication-taking ('implementation') patterns are most likely to lead to subo...
Angelique E Boutzoukas,Stephen J Balevic,Marion Hemmersbach-Miller et al.
Angelique E Boutzoukas et al.
Background and objective: We conducted an opportunistic pharmacokinetic study to evaluate the population pharmacokinetics of meropenem, an antimicrobial commonly used to treat Gram-negative infections in adults of differe...
Correction: Population Pharmacokinetic Analysis of Tucatinib in Healthy Participants and Patients with Breast Cancer or Colorectal Cancer [0.03%]
纠正：Tucatinib在健康受试者和乳腺癌或结直肠癌患者中的群体药代动力学分析
Daping Zhang,Adekemi Taylor,Jie Janet Zhao et al.
Daping Zhang et al.
Published Erratum
Clinical pharmacokinetics. 2024 Dec 11. DOI:10.1007/s40262-024-01458-0 2024
Static Versus Dynamic Model Predictions of Competitive Inhibitory Metabolic Drug-Drug Interactions via Cytochromes P450: One Step Forward and Two Steps Backwards [0.03%]
关于细胞色素P450介导的代谢药物相互作用的竞争性抑制：静态与动态模型预测的一个进步和两步倒退
Ivan Tiryannik,Aki T Heikkinen,Iain Gardner et al.
Ivan Tiryannik et al.
Background: Predicting metabolic drug-drug interactions (DDIs) via cytochrome P450 enzymes (CYP) is essential in drug development, but controversy has reemerged recently about whether in vitro-in vivo extrapolation (IVIVE...
All You Need to Know About Allometric Scaling: An Integrative Review on the Theoretical Basis, Empirical Evidence, and Application in Human Pharmacology [0.03%]
有关异倍性放大的所有内容：理论基础、实证证据及人体药理学应用的综合述评
Daan W van Valkengoed,Elke H J Krekels,Catherijne A J Knibbe
Daan W van Valkengoed
Scaling approaches are used to describe or predict clearance for paediatric or obese populations from normal-weight adult values. Theoretical allometry assumes the existence of a universal bodyweight-based scaling relationship. Although the...