Population Pharmacokinetic Modeling of Oxcarbazepine and Its Active Metabolite 10-Monohydroxy Derivative to Inform Dosing in Children with Obesity [0.03%]
用于肥胖儿童奥卡西平剂量调整的群体药动学研究及其活性代谢产物10-单羟基衍生物的研究
Jaydeep Sinha,Kanecia Zimmerman,Stephen J Balevic et al.
Jaydeep Sinha et al.
Background: Oxcarbazepine (OXZ) is an antiepileptic drug whose pharmacological effect is primarily mediated by its active metabolite, 10-monohydroxy derivative (MHD). OXZ is approved for use in adults and children older t...
Population Pharmacokinetics of Atogepant for the Prevention of Migraine [0.03%]
用于预防偏头痛的Atogepant群体药代动力学分析
Louisa Schlachter,Sven Stodtmann,Alexander Voelkner et al.
Louisa Schlachter et al.
Background and objective: Atogepant is an oral calcitonin gene-related peptide receptor antagonist developed for the preventive treatment of migraine. This work aimed to develop a population pharmacokinetic (popPK) model ...
Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum [0.03%]
在孕期和产后预测替诺福韦酯和特诺福韦艾拉酚胺在血浆和细胞基质中的暴露量的半机制化群体药代动力学模型的发展
Yifan Yu,Kristina M Brooks,Gustavo F Doncel et al.
Yifan Yu et al.
Background and objective: Tenofovir (TFV)-based regimens are backbones of both HIV treatment and pre-exposure prophylaxis during pregnancy. Multiple studies have shown up to one-third decreases in dried blood spot tenofov...
A Population Pharmacokinetic and Exposure-Response Analysis for Baricitinib in Pediatric Patients with Atopic Dermatitis [0.03%]
巴瑞克替尼治疗特应性皮炎儿科患者的群体药代动力学和暴露反应关系分析
Rodney L Decker,C Steven Ernest nd,David B Radtke et al.
Rodney L Decker et al.
Background: Baricitinib is approved for the treatment of adults with moderate-to-severe atopic dermatitis (AD) who are candidates for systemic therapy and has received regulatory authorization in Europe for moderate-to-se...
Systematic Search of Height and Weight Changes of Exclusively Breastfed Infants Until 1 Year of age: A Contribution from the ConcePTION Project [0.03%]
为期一年的纯母乳喂养婴儿体重和身高的系统化监测研究：CONCEPTION项目成果之一
Martje Van Neste,Julia Macente,Nina Nauwelaerts et al.
Martje Van Neste et al.
Physiologically based pharmacokinetic (PBPK) modelling and simulation allows prediction of drug exposure in specific populations, such as infants during lactation. However, the influence of feeding type (e.g., human milk vs formula) on phys...
Population Pharmacokinetics of a Novel Oral Fosfomycin Prophylactic Scheme in the Plasma and Prostate of Patients Undergoing Endoscopic Surgery for Benign Prostatic Hyperplasia [0.03%]
经尿道前列腺切除术患者新型口服磷霉素预防方案的群体药代动力学研究：基于血浆和前列腺中的药物浓度
Pier Giorgio Cojutti,Pasquale Maria Berrino,Valeria Rotaru et al.
Pier Giorgio Cojutti et al.
Background and objective: Fosfomycin trometamol may be a valuable option for antimicrobial prophylaxis before urological surgery for benign prostatic hyperplasia. The objective is to develop a population pharmacokinetic m...
Low Target Attainment of Intravenous Cefuroxime in Critically Ill Term Neonates and Children: A Pooled Population Pharmacokinetics Study [0.03%]
危重新生儿和儿童静脉注射头孢呋辛血药浓度未达靶值：人群药代动力学研究
Stef Schouwenburg,Tim Preijers,Roelie M Wösten-van Asperen et al.
Stef Schouwenburg et al.
Background and objective: Cefuroxime is a widely prescribed beta-lactam antibiotic, particularly in pediatric cardiac and medical-surgical intensive care units. The aim of this study was to describe intravenous cefuroxime...
Population Pharmacokinetics Analysis of Infliximab in up to 10-Year-Old Patients with Paediatric Inflammatory Bowel Disease: Label-Recommended Dose Fails to Achieve Therapeutic Target Concentration [0.03%]
英夫利西单抗治疗儿童及青少年炎症性肠病患者的人群药代动力学分析：说明书推荐剂量不能达到药物的治疗目标浓度
Q Zhao,M M E Jongsma,S A Vuijk et al.
Q Zhao et al.
Background and objectives: Younger patients with paediatric inflammatory bowel disease (IBD) may require higher infliximab (IFX) doses to attain similar target trough levels compared with older paediatric and adult patien...
How is Levetiracetam Monotherapy Currently Monitored in Pregnancy? A Systematic Review [0.03%]
妊娠期间利维他西坦单药治疗的监测现状如何？一项系统综述
Tessa Rademaker,Yeonyung Goo,May Ching Soh et al.
Tessa Rademaker et al.
Background: Levetiracetam is commonly used as antiepileptic drug during pregnancy and has a well-established safety profile in that setting. Pregnancy-related pharmacokinetic changes may result in decreased levetiracetam ...
Randomized, Double-Blind, Phase I Pharmacokinetic Study of Subcutaneous Recombinant Human Superoxide Dismutase (rhSOD) in Healthy Volunteers [0.03%]
重组人超氧化物歧化酶（rhSOD）健康受试者皮下注射I期随机、双盲药物动力学研究
Valentin Al Jalali,Martin Bauer,Anselm Jorda et al.
Valentin Al Jalali et al.
Background: Excessive production of reactive oxygen species (ROS), particularly superoxide anion ( O 2 · - ), is a key mechanism in diseases such as cancer, inflammatory disorders, neurodegenerative conditions, and...