Efficacy and Safety of Upadacitinib in Patients With Moderate-to-Severe Atopic Dermatitis: Phase 3 Randomized Clinical Trial Results Through 140 Weeks [0.03%]
乌帕替尼治疗中重度特应性皮炎疗效和安全性：为期140周的III期随机临床试验结果
Alan D Irvine,Vimal H Prajapati,Emma Guttman-Yassky et al.
Alan D Irvine et al.
Background: Upadacitinib is an oral selective Janus kinase inhibitor approved to treat moderate-to-severe atopic dermatitis (AD) in adults and adolescents; long-term efficacy and safety data beyond 1 year are needed. ...
Joseph F Merola,Stephan Weidinger,Sally Y Tan et al.
Joseph F Merola et al.
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by fluctuating disease activity. Exacerbations of AD signs and/or symptoms, or flares, have a significant impact on patient quality of life and may require modifi...
Exploring Suzetrigine's Role in Dermatologic Surgery: A Novel Nonopioid Analgesic for Postoperative Pain Management [0.03%]
苏泽曲林在皮肤外科手术中作用的探索：一种新型非阿片类术后镇痛药
William J Nahm,Sameer G Gupta,Ryan Chen et al.
William J Nahm et al.
Francis Li-Tien Hsu,Tsen-Fang Tsai
Francis Li-Tien Hsu
Background: Ethnic differences in the clinical and molecular features of many immune-mediated dermatoses have been reported, including psoriasis vulgaris and generalized pustular psoriasis. Palmoplantar pustulosis (PPP) i...
Bimekizumab Complete Clearance of Both Skin and Nail Psoriasis: Comparative Efficacy in Phase III/IIIb Studies [0.03%]
Bimekizumab实现皮肤及甲银屑病的完全清除：III期和IIIb期研究中的疗效比较
Joseph F Merola,Richard B Warren,Diamant Thaçi et al.
Joseph F Merola et al.
Background: Nail psoriasis can have a substantial negative impact on both the physical and emotional well-being of patients, and is a risk factor for psoriatic arthritis. Achieving complete clearance of nails in addition ...
Management of Erythrodermic Psoriasis with Systemic Therapies: A Systematic Review [0.03%]
全身治疗红皮病性银屑病的管理：系统评价
Luca Mastorino,Francesco Leo,Giada Frigatti et al.
Luca Mastorino et al.
Background: Erythrodermic psoriasis (EP) is a severe and rare variant of psoriasis. Clinical features include scaling and erythema affecting more than 75% of body surface area, associated with systemic symptoms such as ly...
Development and Validation of an Artificial Intelligence-Driven Model for Accurate Classification of Erythrodermic Psoriasis Severity: Erythrodermic Psoriasis Integrated Classification System (EPICS) [0.03%]
用于准确分类红皮病型银屑病严重程度的人工智能驱动模型的开发和验证：红皮病性银屑病综合分类系统（EPIC系统）
Yuyan Yang,Chao Wu,Xinyuan Zhang et al.
Yuyan Yang et al.
Background: Erythrodermic psoriasis is a rare subtype of psoriasis with widespread skin lesions, with some patients experiencing severe systemic symptoms. ...
Lichen Simplex Chronicus: Clinical Perspectives and Emerging Therapeutic Strategies [0.03%]
慢性单纯性苔藓的临床特点及治疗策略展望
Michal Moshkovich,Luis F Andrade,Mike Anderson et al.
Michal Moshkovich et al.
Lichen simplex chronicus (LSC), also known as neurodermatitis, is a common chronic pruritic dermatosis defined by lichenified plaques resulting from persistent scratching. Though often secondary to underlying dermatologic, systemic, or psyc...
Michelle Yuan,Jinwoo Lee,Mark Taylor et al.
Michelle Yuan et al.
The growing availability of targeted immunomodulatory therapies has transformed the treatment landscape for chronic inflammatory skin diseases. However, treatment selection remains largely empirical, often guided more by trial-and-error and...
Psoriasis: Considerations for the Management of Women of Childbearing Potential [0.03%]
关于备孕期女性银屑病管理的考量
Signe Agnete Rønde Kristensen,Amanda Kvist-Hansen,Lone Skov
Signe Agnete Rønde Kristensen
As women of childbearing potential constitute a considerable portion of the total psoriasis population, dermatologists must consider both the clinical and psychosocial implications of psoriasis when treating these patients. This review summ...