Antihypertensive Efficacy and Safety of Angiotensin Receptor Blockers (ARBs) with and without Inverse Agonism: A Systematic Review and Network Meta-analysis [0.03%]
血管紧张素受体阻滞剂（ARB）类降压药的有效性和安全性：系统性回顾和网状Meta分析
Jing Liu,Jialu Geng,Jiakun Liu et al.
Jing Liu et al.
Introduction: While not all angiotensin receptor blockers (ARBs) exhibit inverse agonistic activity, certain ARBs with this property may offer greater potential for blood pressure (BP) reduction compared with ARBs without...
Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence [0.03%]
基于培哚普利的降压药单片与自由联合方案依从性及医疗成本的11年真实世界证据研究
Gianluigi Savarese,Ana-Maria Vintila,Luca Degli Esposti et al.
Gianluigi Savarese et al.
Background: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study c...
Comparative Effectiveness of Sacubitril/Valsartan Versus Sodium-Glucose Cotransporter 2 Inhibitors among Patients with Heart Failure with Reduced Ejection Fraction with or without Diabetes: A Cohort Study [0.03%]
与钠-葡萄糖共转运蛋白2抑制剂相比，沙库巴曲/缬沙坦在射血分数降低的心衰患者（无论是否有糖尿病）中的有效性：队列研究
Munaza Riaz,Steven M Smith,David E Winchester et al.
Munaza Riaz et al.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and sacubitril/valsartan (SAC/VAL), an angiotensin receptor-neprilysin inhibitor, are both US Food and Drug Administration-approved and guideline-recommended ...
When Methods Matter: An Umbrella Review of Lorundrostat and the Impact of Analytical Decisions on Reported Blood Pressure and Safety Outcomes [0.03%]
方法的重要性：Lorundrostat的伞式回顾及其分析决策对报告血压和安全结果的影响
Zeyad Elariny,Omar Salem,Mohamad Ashraf Salaheldin et al.
Zeyad Elariny et al.
Background: Lorundrostat has emerged as a promising therapy for uncontrolled and/or resistant hypertension, with multiple systematic reviews and meta-analyses (SRMAs) evaluating its blood pressure effects and hyperkalemia...
Aspirin Versus Clopidogrel as Single Antiplatelet Therapy After TAVI: A Propensity Score-Matched, Retrospective Analysis [0.03%]
经皮主动脉瓣植入术后阿司匹林与氯吡格雷作为单药抗血小板治疗的对比：倾向性评分匹配的回顾性分析
Anastasios Apostolos,Konstantinos Konstantinou,Mohammed Allaf et al.
Anastasios Apostolos et al.
Background: Current guidelines recommend single antiplatelet therapy (SAPT) with aspirin for most patients undergoing transcatheter aortic valve implantation (TAVI). However, the optimal choice of SAPT, namely aspirin or ...
Empagliflozin in STEMI Patients: A Randomized Controlled Trial on Left Ventricular Recovery and Cardiovascular Outcomes [0.03%]
恩格列净与STEMI患者左室重构及心血管结局的一项随机试验
Fatemeh Baharvand,Roxana Mehran,Francesca Maria Di Muro et al.
Fatemeh Baharvand et al.
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors provide cardiovascular benefits in diabetes, but their role in the acute post-myocardial infarction (MI) setting is uncertain. This study evaluated the associa...
Food Effects on the Pharmacokinetics of Single Dose and Steady-State Ralinepag, a Novel Oral Prostacyclin Agonist, in Healthy Volunteers [0.03%]
食物对健康志愿者单剂量和稳态拉利纳帕格（一种新型口服前列环素激动剂）药代动力学的影响
Daniel Lachant,Cristian E Botta,George Giannakoulas et al.
Daniel Lachant et al.
Background: Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by pathological pulmonary vascular remodeling leading to right heart failure. Ralinepag extended-release (XR), is a once-dail...
Using Artificial Intelligence to Identify Patterns and Predictors of Adverse Drug Reactions in Cardiovascular Patients: A Comprehensive Narrative Review [0.03%]
运用人工智能识别心血管病患不良药物反应的模式和预测因素：全面叙述性综述
Erfan Shahabinejad,Fatemeh Soflaei-Shahrbabak,Marzieh Gholami Shoa et al.
Erfan Shahabinejad et al.
Artificial intelligence (AI) has emerged as a transformative tool for improving the detection, prediction, and prevention of adverse drug reactions (ADRs) in cardiovascular (CV) medicine, a domain characterized by high drug utilization, com...
Combination Therapy of GLP-1 RA and SGLT2i in Patients with Established Heart Failure: A Systematic Review and Meta-Analysis of Observational Studies [0.03%]
葡萄糖依赖性胰岛素释放肽受体激动剂与钠-葡萄糖共转运蛋白2抑制剂联合治疗心力衰竭患者的系统评价和 meta 分析：一项观察性研究
Christopher Daniel Tristan,Irnizarifka Irnizarifka,Erlangga Masykur Kynaya et al.
Christopher Daniel Tristan et al.
Background: A combination of Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) and a Sodium-Glucose co-transporter-2 Inhibitor (SGLT2i) has demonstrated complementary benefits. This analysis aimed to compare combination...
GLP-1 Receptor Agonists and Cardiovascular Outcomes in Patients with Type 2 Diabetes Across Myocardial Infarction-Defined Populations: A Systematic Review and Meta-Analysis [0.03%]
在不同心肌梗死定义的人群中，GLP-1受体激动剂对2型糖尿病患者心血管结局的影响：系统评价和meta分析
Pedro Gomes Batista,Railla Raquel Albino Dos Santos Silva,Marcela Vasconcelos Montenegro et al.
Pedro Gomes Batista et al.
Background: Patients with type 2 diabetes mellitus (T2DM) who survive myocardial infarction (MI) remain at high risk for recurrent cardiovascular events and heart failure (HF). Although glucagon-like peptide-1 receptor ag...