Evaluation of a Newly Developed Transdiagnostic Cognitive Behavioral Therapy Group to Promote Healthy Aging Among Older People with HIV: Study Protocol for a Pilot Randomized Controlled Trial [0.03%]
一种新型跨诊断认知行为治疗小组促进HIV阳性老年人健康老龄化项目的评价：一项初步随机对照试验的研究方案
Jacklyn D Foley,Lauren B Bernier,Stephanie Schiavo et al.
Jacklyn D Foley et al.
In the era of expanded access to effective antiretroviral therapy (ART), the life expectancy of the estimated 1.2 million people with HIV (PWH) in the United States has significantly increased. There is a timely need to develop and evaluate...
Women in Control: Pioneering Diabetes Self-Management Medical Group Visits in the Virtual World [0.03%]
巾帼不让须眉：糖尿病自我管理先驱医学小组探访虚拟世界
S Mitchell,P Gardiner,G Weigel et al.
S Mitchell et al.
Background: The current state of diabetes self-management (DSM) education and support for diabetic patients is inadequate, especially for minority women who experience disproportionately high rates of diabetes mellitus (D...
Taking Optogenetics into the Human Brain: Opportunities and Challenges in Clinical Trial Design [0.03%]
光学遗传学在人脑中的应用：临床试验设计的机遇与挑战
Michael White,Michael Mackay,Roger Whittaker
Michael White
Optogenetics, the use of light to control the activity of suitably sensitized cells, has led to major advances in the field of basic neuroscience since it first emerged in 2005. Already, the technique has entered clinical trials for conditi...
Life Enhancing Activities for Family Caregivers of people with dementia: protocol for a randomized controlled trial of a positive affect skills intervention [0.03%]
改善痴呆患者家庭护理人员生活的活动技能干预临床试验方案
Alice Verstaen,Judith T Moskowitz,Karin E Snowberg et al.
Alice Verstaen et al.
Given the increasing number of family caregivers of persons with dementia (PWD) and the associated burden and detriments to both physical and mental health, interventions that aim to improve such outcomes are important. Studies are increasi...
MCLENA-1: A Phase II Clinical Trial for the Assessment of Safety, Tolerability, and Efficacy of Lenalidomide in Patients with Mild Cognitive Impairment Due to Alzheimer's Disease [0.03%]
LENALIDOMIDE治疗阿尔茨海默病轻度认知障碍患者Ⅱ期临床研究（MCLENA-1）：疗效和安全性的评估
Boris Decourt,Jeffrey Wilson,Aaron Ritter et al.
Boris Decourt et al.
With the general population reaching higher ages, a surge in Alzheimer's disease (AD) incidence will happen in the coming decades, putting a heavy burden on families and healthcare systems Worldwide. This emphasizes the pressing need for AD...
Computerized Cognitive Training to Improve Mood in Senior Living Settings: Design of a Randomized Controlled Trial [0.03%]
改善老年生活设施中老年人情绪的计算机认知训练：一项随机对照试验的设计
Marianne Smith,Michael P Jones,Megan M Dotson et al.
Marianne Smith et al.
Purpose: This two-arm, randomized controlled trial was designed to evaluate a computerized cognitive speed of processing (SOP) training known as Road Tour in the generally older group of adults residing in assisted living...
The role of functional, social, and mobility dynamics in facilitating older African Americans participation in clinical research [0.03%]
功能、社会和移动动态在促进非裔美国人参与临床研究中的作用
Eve T Shapiro,Jay T Schamel,Kimberly A Parker et al.
Eve T Shapiro et al.
Purpose: Older African Americans experience disproportionately higher incidence of morbidity and mortality related to chronic and infectious diseases, yet are significantly underrepresented in clinical research compared t...
Phase I dose-escalation trial of intravaginal curcumin in women for cervical dysplasia [0.03%]
用于宫颈上皮内瘤变妇女的姜黄素阴道给药I期剂量递增试验
Leda Gattoc,Paula M Frew,Shontell N Thomas et al.
Leda Gattoc et al.
Background: This is a Phase I trial demonstrating safety and tolerability of intravaginal curcumin for future use in women with cervical neoplasia. Object...
Critical Illness Outcome Study: An Observational Study on Protocols and Mortality in Intensive Care Units [0.03%]
重症监护病房诊疗方案与病死率观察研究
Naeem A Ali,David Gutteridge,Sajid Shahul et al.
Naeem A Ali et al.
Introduction: Many individual Intensive Care Unit (ICU) characteristics have been associated with patient outcomes, including staffing, expertise, continuity and team structure. Separately, many aspects of clinical care i...
André P Gabriel,Charles P Mercado
André P Gabriel
Patient retention is critically important in the conduct of a successful clinical trial. The power in numbers in multicenter trials is dependent on the completion of follow-up for every patient randomized. If at the end of a clinical trial,...