Novel Approaches to Treating Relapsed and Refractory Multiple Myeloma with a Focus on Recent Approvals of Belantamab Mafodotin and Selinexor [0.03%]
复发和难治性多发性骨髓瘤的新型治疗方法：重点关注Belantamab Mafodotin 和Selinexor 的最新批准
Nisha S Joseph,Yu-Tzu Tai,Kenneth C Anderson et al.
Nisha S Joseph et al.
Though survival outcomes in multiple myeloma patients have improved drastically over the past few decades, there still remains an ongoing need for effective and tolerable treatment options in the relapsed and refractory space. Encouragingly...
Evaluation of Antimalarial Activity of 80% Methanolic Root Extract of Dorstenia barnimiana Against Plasmodium berghei-Infected Mice [0.03%]
评估Dorstenia barnimiana根部提取物的抗疟活性对抗Plasmodium berghei小鼠模型的影响
Dagninet Derebe,Muluken Wubetu,Amare Alamirew
Dagninet Derebe
Background: Due to resistance of parasites, costs, and safety issues with currently available drugs, there is a need to discover new antimalarials. Medicinal plants are one of the most important sources of new drugs. The ...
Evaluation of the Pharmacokinetics of Trazpiroben (TAK-906), a Peripherally Selective D2/D3 Dopamine Receptor Antagonist, in the Presence and Absence of Itraconazole, a Potent CYP 3A4 Inhibitor [0.03%]
他唑匹罗苯(TAK-906，一种外周选择性D2 / D3多巴胺受体拮抗剂)在三唑康唑(强效CYP 3A4抑制剂)存在和不存在情况下的药代动力学评估研究
Chunlin Chen,Wenwen Zhang,Muhammad Bari et al.
Chunlin Chen et al.
Purpose: Treatment options for gastroparesis, such as metoclopramide and domperidone, are limited because of safety concerns, which may be exacerbated in the presence of inhibitors of drug metabolism. This study evaluated...
Guselkumab for the Treatment of Palmoplantar Pustulosis: A Japanese Perspective [0.03%]
Guselkumab治疗掌跖脓疱病的日本视角
Toshiyuki Yamamoto
Toshiyuki Yamamoto
Palmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles. PPP is refractory to various therapies such as topical ointment, oral medicine, and phototherapi...
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study [0.03%]
ATI-450在健康志愿者中的安全性和耐受性、药代动力学及药效学：一项安慰剂对照的随机Ⅰ期研究
David Gordon,Edward T Hellriegel,Heidi Rath Hope et al.
David Gordon et al.
Purpose: ATI-450 is an oral, small-molecule inhibitor of the p38α mitogen-activated protein kinase (MAPK)/MAPK-activated protein kinase 2 (MK2) inflammatory signaling pathway. This phase 1, single and multiple ascending ...
Rupatadine Oral Solution Titration by Body Weight in Paediatric Patients Suffering from Allergic Rhinitis: A Population Pharmacokinetic Study [0.03%]
基于体重的鲁帕他定口服溶液滴定在过敏性鼻炎儿童患者中的药代动力学研究
Eva Santamaria,Iñaki Izquierdo,Marta Valle
Eva Santamaria
Background: Allergic rhinitis (AR) and chronic urticaria, both are treated in children with doses of second generation of antihistamines that have been mostly based on extrapolation of data obtained in adults. The objecti...
Determination of Caffeine and Hydrogen Peroxide Antioxidant Activity of Raw and Roasted Coffee Beans Around Habru Woreda, Ethiopia Using UV-Vis Spectroscopy [0.03%]
紫外可见分光光度法测定哈布鲁区生熟咖啡豆中咖啡因含量及氢过氧化物抗氧化活性
Beshir Legas Muhammed,Mohammed Hussen Seid,Adere Tarekegne Habte
Beshir Legas Muhammed
Background: Coffee is a well-known beverage that is widely used around the world. Despite the wide use of coffee in Ethiopia, there is a lack of extensive studies addressing the issues related to the caffeine content and ...
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain [0.03%]
评估新型低剂量姜黄提取配方在慢性膝关节疼痛的健康成人中有效性和安全性的多中心、随机、双盲、安慰剂对照试验
Shefali Thanawala,Rajat Shah,Venkateswarlu Somepalli et al.
Shefali Thanawala et al.
Background: Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N®-WDTE60N),...
Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria [0.03%]
二甲双胍可能是一种潜在的抗菌辅助药物可对抗多重耐药细菌
Majed M Masadeh,Karem H Alzoubi,Majd M Masadeh et al.
Majed M Masadeh et al.
Introduction: The continuous increase in the incidence of bacterial resistance to existing antibiotics represents a worldwide health burden. A surrogate strategy to combat such crisis is to find compounds that restore the...
An Investigator-Initiated, Prospective, Single-Center, Open-Label Clinical Study to Evaluate Safety and Performance of Intra-Articular Hyaluronic Acid (IA-HA) (Biovisc Ortho) in Patients with Osteoarthritis (OA) of the Knee [0.03%]
一项评价透明质钠（骨维圣）关节腔内注射在膝骨关节炎患者中安全性和有效性的前瞻性、单中心、开放标签的探索者发起临床研究
Ajay Gupta,Chethan Channaveera,Vijender Anand et al.
Ajay Gupta et al.
Objective: IA-HA is injected into the osteoarthritis knee as a viscosupplementation for therapeutic purposes. This clinical trial was carried out for evaluating the efficacy and safety of Biovisc Ortho IA-HA (20 mg/2 mL) ...