Lenacapavir at the Spatiotemporal Limit: Tissue Pharmacokinetics, Pharmacokinetic Tail Dynamics, and the Emergence of Capsid Resistance in Long-Acting HIV Prevention [0.03%]
长效HIV预防中LENACAPAVIR的时空极限：组织药代动力学、药代动力尾部特征及衣壳耐药的出现
Hans Chinomso Chris-Uchendu,Gerald Olwit,Arnold Atuhaire et al.
Hans Chinomso Chris-Uchendu et al.
Background: Lenacapavir (LEN), a first-in-class HIV-1 capsid inhibitor administered subcutaneously twice yearly, has demonstrated near-perfect efficacy in Phase 3 trials, generating justified enthusiasm for its potential ...
Transcriptomic Modulation of Inflammasome-Related Genes Following Metformin Administration in Breast Cancer Patients with Paclitaxel-Induced Neuropathy [0.03%]
二甲双胍调节紫杉醇诱发的乳腺癌患者的炎性小体相关基因转录组学变化
Alireza Malayeri,Mehdi Etemad Nezhad,Farrokh Ramesh et al.
Alireza Malayeri et al.
Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of paclitaxel therapy. The inflammasome complex, including apoptosis-associated speck-like protein containing a CARD (ASC), Caspas...
Incidence and Risk Factors of Chemotherapy-Induced Nausea and Vomiting Among Adult Cancer Patients at Mbarara Regional Referral Hospital: A Prospective Study [0.03%]
马巴拉拉地区转诊医院成人癌症患者化疗引起的恶心呕吐的发病情况及危险因素：一项前瞻性研究
Patrick Kitheka Muasya,Tadele Mekuriya Yadesa,John Isiiko et al.
Patrick Kitheka Muasya et al.
Background: Chemotherapy-induced nausea and vomiting (CINV) remains a significant and distressing adverse effect of cancer treatment, adversely affecting patients' quality of life. Despite well-established international g...
Recurrent/Refractory Multidrug- and Pre-Multidrug-Resistant Pseudomonas aeruginosa Infection Cases Maintained by Long-Term, Low-Dose Macrolide Administration [0.03%]
长期低剂量麦角脂维持的反复发作和难治性多重耐药和全耐药绿脓杆菌感染案例
Masafumi Seki
Masafumi Seki
Multidrug-resistant Pseudomonas aeruginosa (MDRP) is usually induced by inappropriate use of broad-spectrum antibiotics, and pre-multidrug-resistant Pseudomonas aeruginosa (pre-MDRP) is defined as resistance to any two of three antibiotics,...
Superior Efficacy and Deep Molecular Remission with Venetoclax Plus Hypomethylating Agent in Elderly Acute Myeloid Leukemia: A Real-World Comparative Cohort Study [0.03%]
用于老年急性髓系白血病患者的维奈克拉联合低甲基化药物疗效更优且可获得深层次分子缓解：一项真实世界队列研究
Chen Luo,Yuhan Jiang,Huiling Yan et al.
Chen Luo et al.
Background: Treatment of elderly acute myeloid leukemia (AML) remains challenging, and intensive chemotherapy is often poorly tolerated in elderly patients due to comorbidities and frailty, thereby necessitating low‑inte...
Protocol for a Prospective, Multicenter Cohort Study on the Treatment of Chronic Cardiorenal Syndrome with Qishen Yiqi Dropping Pills [0.03%]
补肾益气滴丸治疗慢性心肾综合征的前瞻性多中心队列研究方案
Guohua Shi,Yiming Zuo,Yuxiao Cao et al.
Guohua Shi et al.
Background: Chronic Cardiorenal Syndrome (CRS types 2/4) involves the mutual exacerbation of heart failure and chronic kidney disease, with over half of heart failure patients affected by renal impairment that increases m...
Chronic Pain in Elderly Patients: Pathophysiology, Pharmacologic and Non-Pharmacologic Therapies, and Interventional Management [0.03%]
老年患者的慢性疼痛：发病机制、药物性和非药物性治疗及介入治疗
Ankur Jain,Eliot Sadik,Alejandra Cardenas-Rojas et al.
Ankur Jain et al.
Purpose: Chronic pain is a debilitating condition faced among the geriatric population, contributing to reduced mobility, impaired daily function, and increased dependence on healthcare services. This review explores the ...
Optimizing Enoxaparin Dosing in Asian Patients: The Critical Role of Age and Renal Function in Achieving Target Anti-Xa Levels [0.03%]
亚洲患者依诺肝素剂量优化：年龄和肾功能在达到抗FXa目标水平中的关键作用
Wenxing Peng,Shuran Yang,Ying Dai et al.
Wenxing Peng et al.
Objective: To investigate the roles of age and renal function in optimizing enoxaparin dosage for achieving target anti-Xa levels in Asian patients. Metho...
Yusra Soorya,Bushirat A Abubakar,Zack Karzoun et al.
Yusra Soorya et al.
Hydrogels are widely used in clinical medicine for drug delivery and tissue repair; however, they exhibit limited mechanical strength, suboptimal degradation profiles, and variable biocompatibility. In order to address inherent shortcomings...
Montelukast and Delirium Risk During Intensive Care Unit (ICU) Stay: Findings from a Cohort Study [0.03%]
蒙拉克斯特与重症监护病房住院期间发生谵妄的风险：一项队列研究的结果
Alaa Almagthali,Khalid Al Sulaiman,Samiah Alsohimi et al.
Alaa Almagthali et al.
Background: Delirium is a frequent complication in critically ill patients and is associated with increased mortality, prolonged hospitalization, and long-term cognitive impairment. Montelukast, a leukotriene receptor ant...