NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment [0.03%]
小细胞肺癌中表达N-甲基-D天冬氨酸受体可能是有效的治疗靶点
William G North,Guohong Gao,Amy Jensen et al.
William G North et al.
We previously showed that functional N-methyl-D-aspartate (NMDA) receptors are expressed by human neuroblastoma cells. In this study we demonstrate functional NMDAR1 and NMDAR2 receptors are expressed by small-cell lung cancer (SCLC) classi...
Dilip R Patel,Cynthia Feucht,Lesley Reid et al.
Dilip R Patel et al.
Tobacco use has been clearly demonstrated to have negative health consequences. Smoking cigarettes is the predominant method of tobacco use. The tar contained within cigarettes and other similar products is also harmful. Other tarless tobac...
Abir O El-Sadik,Afaf El-Ansary,Sherif M Sabry
Abir O El-Sadik
Nanotechnology has been described as a general purpose technology. It has already generated a range of inventions and innovations. Development of nanotechnology will provide clinical medicine with a range of new diagnostic and therapeutic o...
The pharmacokinetics of valganciclovir prophylaxis in pediatric solid organ transplant patients at risk for Epstein-Barr virus disease [0.03%]
Valganciclovir预防儿科实体器官移植患者EB病毒感染的药代动力学研究
Heather E Vezina,Richard C Brundage,Thomas E Nevins et al.
Heather E Vezina et al.
Antiviral prophylaxis with valganciclovir is used frequently in pediatric solid organ transplant patients to prevent Epstein-Barr virus (EBV)-induced infections and tissue-invasive disease including post-transplant lymphoproliferative disor...
Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent [0.03%]
慢性氟西汀治疗增加啮齿动物白天的褪黑素合成
Gillian W Reierson,Claudio A Mastronardi,Julio Licinio et al.
Gillian W Reierson et al.
Circadian rhythm disturbances can occur as part of the clinical symptoms of major depressive disorder and have been found to resolve with antidepressant therapy. The pineal gland is relevant to circadian rhythms as it secretes the hormone m...
Meghna Adhvaryu,Bhasker Vakharia
Meghna Adhvaryu
Multidrug-resistant tuberculosis has emerged worldwide, with an increasing incidence due to failure of implementation of apparently effective first-line antituberculous therapy as well as primary infection with drug-resistant strains. Failu...
Reduced dose maintenance eculizumab in atypical hemolytic uremic syndrome (aHUS): an update on a previous case report [0.03%]
补体治疗溶血性尿毒症综合征1例报告的后续
Maro Ohanian,Christian Cable,Kathleen Halka
Maro Ohanian
Objective: To describe how maintenance eculizumab sustains improved renal function in severe atypical hemolytic uremic syndrome (aHUS). Case report: ...
Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions [0.03%]
托珠单抗和阿那白滞素在类风湿关节炎患者中的肝毒性：治疗决策
Mahmud Mahamid,Reuven Mader,Rifaat Safadi
Mahmud Mahamid
Background: Elevation of liver enzymes in rheumatoid arthritis patients treated with tocilizumab (Actemra(®)) or anakinra (Kineret(®)) is a well-documented phenomenon. However, characterization of liver histology has no...
Scott E Nelson
Scott E Nelson
Background: Insulin detemir, a long-acting basal insulin analog, is labeled for once-daily or twice-daily dosing in patients with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus. Protocols for some earlier clinical studi...
Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole [0.03%]
沙格列汀与cytochrome p450底物或抑制剂的双向药代动力学交互作用研究：辛伐他汀、地尔硫革缓释片和酮康唑
Chirag G Patel,Li Li,Suzette Girgis et al.
Chirag G Patel et al.
Background: Many medicines, including several cholesterol-lowering agents (eg, lovastatin, simvastatin), antihypertensives (eg, diltiazem, nifedipine, verapamil), and antifungals (eg, ketoconazole) are metabolized by and/...