Recurrent Checkpoint Inhibitor-Related Pneumonitis Refractory to Corticosteroid Treatment: A Case Report and Literature Review [0.03%]
反复糖皮质激素治疗无效的免疫检查点抑制剂相关性肺炎一例及文献复习
Jinyu Yu,Xuanjun Liu,Xingjiao Ma et al.
Jinyu Yu et al.
Background: Immune checkpoint inhibitors (ICIs) are antibodies that activate the immune system to kill tumor cells and have been widely used in oncology. However, dysregulated immune activation may result in the attack of...
Optimizing Antimicrobial Use in Japan: Strategies for Dosage, Combination Therapy, De-Escalation, Oral Switching, Duration, and Guideline Adherence [0.03%]
日本抗菌药物使用的优化：剂量、联合治疗、降阶梯治疗、口服转换、疗程和指南依从性的策略
Masafumi Seki
Masafumi Seki
Antimicrobial stewardship has gained momentum in Japan, prompting the adoption of various strategies to optimize antimicrobial use. Key recommendations include individualized dosing, dosing intervals, and treatment regimens tailored to the ...
Dose Optimization of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia [0.03%]
酪氨酸激酶抑制剂治疗慢性髓性白血病的剂量优化
Jiali Chen,Yidan Zhu,Yinyu Zhao et al.
Jiali Chen et al.
With the advent of newer treatments such as new molecular targeted agents and immunotherapies, the model that selects therapeutic doses on the basis of the maximum tolerated dose is no longer relevant. The emergence of tyrosine kinase inhib...
Zouina Sarfraz,Arun Maharaj,Vyshak Alva Venur et al.
Zouina Sarfraz et al.
Glioblastoma (GB) is an aggressive brain tumor with standard therapies offering limited but measurable survival benefit. Immunotherapy is expanding the treatment landscape for GB. Immune checkpoint inhibitors (ICIs), including nivolumab and...
Xue Jiang,Yangyang Zhan,Dong-Hua Yang et al.
Xue Jiang et al.
Gastrointestinal cancer is one of the most prevalent malignant tumors worldwide. The treatment landscape of gastrointestinal cancer has entered a new era with the advent of immunotherapy, which activates the immune system to identify and el...
Diagnostic Significance of Paraneoplastic Neuronal Antibodies in Japanese Adults with Autoimmune Encephalitis: A Case Series Study in an Adult Epilepsy Clinic [0.03%]
日本成人自身免疫性脑炎患者相关肿瘤神经元抗体的诊断意义：成人癫痫诊所病例系列研究
Masako Kinoshita,Kozue Takada,Hiroya Ohara et al.
Masako Kinoshita et al.
Purpose: Recently, the role of autoimmune mechanisms in epileptogenesis and intractability has attracted attention. The clinical features of autoimmune encephalitis (AE) vary; thus, diagnosis can be difficult and often de...
The Effect of Drug-Drug Interactions on the Pharmacokinetics of Isavuconazole: A Comprehensive Review [0.03%]
伊萨康唑药物相互作用的药动学效应综述
Yanlei Sang,Qiang Xu,Anna Gao et al.
Yanlei Sang et al.
Purpose: Isavuconazole is an azole antifungal drug, which is used for invasive aspergillosis and mucormycosis. The objective of this study was to comprehensive review the impact of drug-drug interactions (DDIs) on isavuco...
Triphenylphosphine-Based Mitochondrial Targeting Nanocarriers: Advancing Cancer Therapy [0.03%]
基于三苯基膦的线粒体靶向纳米载体：推进癌症治疗
Mohd Shoab Ali,B H Jaswanth Gowda,Rahul Shukla et al.
Mohd Shoab Ali et al.
Numerous chemotherapeutic drugs are commercially available for cancer treatment; however, their efficacy is often compromised by diminishing therapeutic effectiveness and unpredictable adverse effects. The lack of specific targeting limits ...
Michel Wakim,Mariana Mezher,Ariel Perez-Perez et al.
Michel Wakim et al.
Primary central nervous system lymphoma (PCNSL) is a rare, aggressive, extranodal lymphoma exclusively located in the central nervous system. High-dose methotrexate (HD-MTX)-based chemotherapy combination regimens are now the standard of ca...
Predictive Analysis of Non-Cardiac Drug-Induced QTc Interval Prolongation: A Cross-Sectional Study [0.03%]
预测性分析非心脏药物所致QTc间期延长问题：一项横断面研究
Nataleen A Albekairy,Reema Abdullah Aldawsari,Sarah Alanazi et al.
Nataleen A Albekairy et al.
Purpose: This study aimed to assess the real-world impacts of non-cardiac drug-induced QTc interval prolongation and identify associated risk factors in acute care settings. ...