Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor [0.03%]
法莫替丁对口服直接Xa因子抑制剂阿哌沙班药代动力学的影响
Vijay V Upreti,Yan Song,Jessie Wang et al.
Vijay V Upreti et al.
Background: Apixaban is an oral, selective, direct factor Xa inhibitor approved for thromboprophylaxis after orthopedic surgery and stroke prevention in patients with atrial fibrillation, and under development for treatme...
Differential characteristics of incobotulinumtoxinA and its use in the management of glabellar frown lines [0.03%]
IncobotulinumtoxinA的临床特征及其在皱眉肌皱纹治疗中的应用效果
Welf Prager
Welf Prager
Objectives: This review examines the pharmacologic and clinical characteristics of incobotulinumtoxinA (Xeomin(®)/Xeomeen(®)/Bocouture(®)/XEOMIN Cosmetic™; botulinum toxin type A [150 kDa]), which is free from complex...
Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven(®)) [0.03%]
新诊断的先天性因子Ⅶ缺乏症及重组活化因子Ⅶ（诺其欣安）的应用
Nicole S Bartosh,Tara Tomlin,Christian Cable et al.
Nicole S Bartosh et al.
This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa). Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than ...
Effect of statin therapy on vaspin levels in type 2 diabetic patients [0.03%]
他汀类药物治疗对2型糖尿病患者血管生成抑制素水平的影响
Sayer I Al-Azzam,Karem H Alzoubi,Jaafar Abu Abeeleh et al.
Sayer I Al-Azzam et al.
Background: Statins are commonly used antihyperlipidemic agents, with anti-inflammatory and immunomodulatory properties that are thought to account for a significant portion of their ability to protect against atheroscler...
A Phase 1, randomized, open-label crossover study to evaluate the safety and pharmacokinetics of 400 mg albaconazole administered to healthy participants as a tablet formulation versus a capsule formulation [0.03%]
一项在健康受试者中比较400 mg阿尔巴康唑片剂与胶囊剂型的I期、随机、开放标签交叉研究：安全性和药代动力学评估
Koen van Rossem,Jenny A Lowe
Koen van Rossem
Background: Albaconazole is a novel triazole being developed for the oral treatment of fungal diseases. Once-weekly oral dosing with 400 mg albaconazole for 24 or 36 weeks resulted in high rates of clinical and mycologica...
Erratum: Update on the management of ulcerative colitis: treatment and maintenance approaches focused on MMX(®) mesalamine. [Corrigendum] [0.03%]
克罗恩病治疗和维持缓解方案-MMX®美沙拉秦的最新研究进展(更正)
K Nanda,Ac Moss
K Nanda
Published Erratum
Clinical pharmacology : advances and applications. 2013:5:21. DOI:10.2147/CPAA.S42466 2013
Jung-Ki Yoon,Arthur E Frankel,Lynn G Feun et al.
Jung-Ki Yoon et al.
Despite recent development of promising immunotherapeutic and targeted drugs, prognosis in patients with advanced melanoma remains poor, and a cure for this disease remains elusive in most patients. The success of melanoma therapy depends o...
Advances in the management of glioblastoma: the role of temozolomide and MGMT testing [0.03%]
胶质母细胞瘤的治疗进展：替莫唑胺和MGMT检测的作用
Reena P Thomas,Lawrence Recht,Seema Nagpal
Reena P Thomas
Glioblastoma (GB) is one of the most lethal forms of cancer, with an invasive growth pattern that requires the use of adjuvant therapies, including chemotherapy and radiation, to prolong survival. Temozolomide (TMZ) is an oral chemotherapy ...
Loading regimen required to rapidly achieve therapeutic trough plasma concentration of teicoplanin and evaluation of clinical features [0.03%]
替考拉宁迅速达到稳态谷浓度的加载方案及其临床特征分析
Masafumi Seki,Kaori Yabuno,Koji Miyawaki et al.
Masafumi Seki et al.
Background: A trough concentration of >20 mg/L is considered the optimal dosage of teicoplanin required to ensure early therapeutic effects against methicillin-resistant Staphylococcus aureus (MRSA) infections including t...
Pierre Heudel,Philippe Cassier,Olfa Derbel et al.
Pierre Heudel et al.
Pazopanib is a multikinase inhibitor which potently inhibits the activity of major receptor tyrosine kinases, including vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, vascular endothelial growt...