Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response [0.03%]
细胞色素P450 3A4*22、PPAR-α和ARNT多态性与氯吡格雷反应性的关系
Rolf P Kreutz,Janelle Owens,Yan Jin et al.
Rolf P Kreutz et al.
Recent candidate gene studies using a human liver bank and in vivo validation in healthy volunteers identified polymorphisms in cytochrome P450 (CYP) 3A4 gene (CYP3A4*22), Ah-receptor nuclear translocator (ARNT), and peroxisome proliferator...
Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects [0.03%]
阿哌沙班在中国健康受试者中的单次和多次给药的药代动力学、药效学及安全性研究
Yimin Cui,Yan Song,Jessie Wang et al.
Yimin Cui et al.
Background: The pharmacokinetics (PK), pharmacodynamics (PD), and safety of apixaban were assessed in healthy Chinese subjects in this randomized, placebo-controlled, double-blind, single-sequence, single- and multiple-do...
Erratum: Atazanavir-bilirubin interaction: a pharmacokinetic-pharmacodynamic model [Corrigendum] [0.03%]
艾替拉韦-胆红素相互作用：药代动力学/药效学模型的更正注释
[This corrects the article on p. 153 in vol. 5, PMID: 24106429.].
Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes [0.03%]
固定配比的Berberis aristata和Silybum marianum标准化提取物联合使用可能比单用Berberis aristata为2型糖尿病患者带来更好的临床血糖获益：一项初步研究
Francesco Di Pierro,Pietro Putignano,Nicola Villanova et al.
Francesco Di Pierro et al.
Background: Berberine is an isoquinoline alkaloid widely used to improve the glucidic and lipidic profiles of patients with hypercholesterolemia, metabolic syndrome, and type 2 diabetes. The limitation of berberine seems ...
High-dose, short-interval daptomycin regimen was safe and well tolerated in three patients with chronic renal failure [0.03%]
达托霉素大剂量短间隔给药方案对3例慢性肾衰患者安全且耐受良好
Kaori Yabuno,Masafumi Seki,Koji Miyawaki et al.
Kaori Yabuno et al.
Background: The recommended daptomycin dosage is 4 or 6 mg/kg/day for the treatment of complicated skin and soft tissue infections or for Staphylococcus aureus bacteremia, endocarditis, and osteomyelitis. Every other day ...
Epithelial cell-adhesion molecule-directed trifunctional antibody immunotherapy for symptom management of advanced ovarian cancer [0.03%]
针对上皮细胞黏附分子的三功能抗体免疫治疗用于晚期卵巢癌的症状管理
Ramez N Eskander,Krishnansu S Tewari
Ramez N Eskander
Despite advances in cytotoxic chemotherapy and surgical cytoreduction, disease recurrence continues to be a troubling problem in patients with advanced-stage epithelial ovarian cancer (EOC). Malignant ascites affects approximately 10% of pa...
Utkarsh H Acharya,Joanne M Jeter
Utkarsh H Acharya
Ipilimumab is a monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 that has been approved by the US Food and Drug Administration for the treatment of metastatic melanoma. Phase III trials have demonstrated an overall surv...
Atazanavir-bilirubin interaction: a pharmacokinetic-pharmacodynamic model [0.03%]
阿塔南vir-胆红素相互作用：药动学-药效学模型
Roberto Lozano,Nieves Domeque,Alberto-Fermin Apesteguia
Roberto Lozano
Purpose: The aim of this work was to analyze the atazanavir-bilirubin relationship, using a new mathematical approach to pharmacokinetic-pharmacodynamic models, for competitive drug interactions based on Michaelis-Menten ...
Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137 [0.03%]
抗CD137免疫刺激单克隆抗体治疗黑色素瘤免疫疗法
Shi-Yan Li,Yizhen Liu
Shi-Yan Li
Knowledge of how the immune system recognizes and attempts to control cancer growth and development has improved dramatically. The advent of immunotherapies for cancer has resulted in robust clinical responses and confirmed that the immune ...