Effects of irbesartan on serum uric acid levels in patients with hypertension and diabetes [0.03%]
厄贝沙坦对高血压合并糖尿病患者血尿酸水平的影响
Makiko Nakamura,Nobuo Sasai,Ichiro Hisatome et al.
Makiko Nakamura et al.
Background: Hyperuricemia has been proposed to be a risk factor for cardiovascular disease and chronic kidney disease. Since diabetes is often complicated by hypertension and hyperuricemia, efficient therapeutic strategy ...
Analysis of factors affecting rehospitalization of patients with chronic kidney disease after educational hospitalization [0.03%]
慢性肾脏病患者经教育干预住院后的再住院影响因素分析
Eiji Kose,Taesong An,Akihiko Kikkawa et al.
Eiji Kose et al.
Background: Chronic kidney disease (CKD) is associated with a high risk of cardiovascular disease complications. Therefore, medical institutions conduct educational hospitalization for early treatment and education of CKD...
Glibenclamide in patients with poorly controlled type 2 diabetes: a 12-week, prospective, single-center, open-label, dose-escalation study [0.03%]
二甲双胍联合格列本脲治疗控制不佳的2型糖尿病患者的一项为期12周的前瞻性、单中心、开放标签、剂量递增研究
Virendra Rambiritch,Breminand Maharaj,Poobalan Naidoo
Virendra Rambiritch
Background: The purpose of this study was to investigate the effect of glibenclamide dose escalation on blood glucose and insulin in patients with poorly controlled type 2 diabetes. ...
Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers [0.03%]
健康志愿者静脉和口服给药后乙酰水杨酸的药代动力学和药效学研究
J Nagelschmitz,M Blunck,J Kraetzschmar et al.
J Nagelschmitz et al.
Background: The pharmacology of single doses of acetylsalicylic acid (ASA) administered intravenously (250 or 500 mg) or orally (100, 300, or 500 mg) was evaluated in a randomized, placebo-controlled, crossover study. ...
Takayuki Kunisawa,Hidefumi Kasai,Makoto Suda et al.
Takayuki Kunisawa et al.
Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. ...
Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways [0.03%]
多发性硬化症的病理生理过程：聚焦红细胞生成素NF-E2相关因子2及相关新兴通路
Philipp Arnold,Deb Mojumder,John Detoledo et al.
Philipp Arnold et al.
Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by the demyelination of neuronal axons. Four different patterns of demyelination have been described, showing the heterogeneity in the immunopathologic...
The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders [0.03%]
影响Nrf2信号通路在退行性疾病和免疫性疾病中的临床潜力
Bifeng Gao,An Doan,Brooks M Hybertson
Bifeng Gao
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2; encoded in humans by the NFE2L2 gene) is a transcription factor that regulates the gene expression of a wide variety of cytoprotective phase II detoxification and antioxidant enzymes throug...
Astrid Wendt,Xavier Adhoute,Paul Castellani et al.
Astrid Wendt et al.
The launch of first-generation protease inhibitors (PIs) is a major step forward in HCV treatment. However, the major advance is up to now restricted to genotype 1 (GT-1) patients. The development of second-wave and second-generation PIs yi...
Special issue of clinical pharmacology: advances and applications in new protein therapeutics modulating tumor immunity [0.03%]
临床药理学专题：调节肿瘤免疫的新蛋白治疗药物的研究进展与应用挑战
Arthur E Frankel
Arthur E Frankel
Hemodialysis does not alter in vitro hepatic CYP3A4 and CYP2D6 metabolic activity in uremic serum [0.03%]
血液透析不影响尿毒症血清体外肝CYP3A4和CYP2D6代谢活性
Brian S Decker,Kalisha D O&#x;Neill,Mary A Chambers et al.
Brian S Decker et al.
There is a paucity of studies evaluating the change in liver metabolism in subjects receiving hemodialysis. The purpose of this study was to compare the effect of uremic toxins on hepatic cytochrome P450 (CYP)3A4 and CYP2D6 metabolism befor...