Marty Hinz,Alvin Stein,Ted Cole
Marty Hinz
The only indication for carbidopa and benserazide is the management of L-3,4-dihydroxyphenylalanine (L-dopa)-induced nausea. Both drugs irreversibly bind to and permanently deactivate pyridoxal 5'-phosphate (PLP), the active form of vitamin...
Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug-drug interaction study [0.03%]
艾唑加滨/瑞替加滨对健康志愿者地高辛药代动力学无影响：药物相互作用研究结果
Debra J Tompson,Christopher S Crean,Mauro Buraglio et al.
Debra J Tompson et al.
Introduction: The potential for ezogabine/retigabine (EZG/RTG) and its N-acetyl metabolite (NAMR) to inhibit the transporter protein P-glycoprotein-(P-gp)-mediated digoxin transport was tested in vitro. EZG/RTG did not in...
Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens [0.03%]
阿柏卡星：治疗耐甲氧西林金黄色葡萄球菌及多重耐药革兰阴性病原体感染的又一新药
Tetsuya Matsumoto
Tetsuya Matsumoto
Arbekacin sulfate (ABK), an aminoglycoside antibiotic, was discovered in 1972 and was derived from dibekacin to stabilize many common aminoglycoside modifying enzymes. ABK shows broad antimicrobial activities against not only Gram-positive ...
Alessia Carocci,Alessia Catalano,Maria Stefania Sinicropi
Alessia Carocci
Melatonin (N-acetyl-5-methoxytryptamine) is widely known as "the darkness hormone". It is a major chronobiological regulator involved in circadian phasing and sleep-wake cycle in humans. Numerous other functions, including cyto/neuroprotect...
Rachel M Kruer,Andrew S Jarrell,Asad Latif
Rachel M Kruer
The Institute of Medicine has reported that medication errors are the single most common type of error in health care, representing 19% of all adverse events, while accounting for over 7,000 deaths annually. The frequency of medication erro...
Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review [0.03%]
布洛芬和吲哚美辛对早产儿肾不良反应的差异：综述
Gian Maria Pacifici
Gian Maria Pacifici
Objective: The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indomethacin in order to choose the safer drug to administer to preterm infants. ...
Administration of supplemental L-tyrosine with phenelzine: a clinical literature review [0.03%]
左旋酪氨酸与苯乙肼联用的临床文献回顾
Marty Hinz,Alvin Stein,Ted Cole et al.
Marty Hinz et al.
The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil(®)) prescribing information notes: "The potentiation of sympathomimetic substances and related co...
Ghada Khoury,Marwan Sheikh-Taha
Ghada Khoury
Objective: We examined the potential effect of sex and age on warfarin dosing in ambulatory adult patients. Methods: We conducted a ret...
In vitro microdialysis membrane efficiency of broad-spectrum antibiotics in combination and alone [0.03%]
广谱抗生素单药及联合用药的体外微透析膜效率研究
Shawn H MacVane,Seth T Housman,David P Nicolau
Shawn H MacVane
Purpose: Microdialysis is a valuable technique for studying the distribution of drugs into interstitial fluid, the target site for a pharmacologic effect. Due to incomplete equilibrium, retrodialysis is a method used to c...
Incidence and management of adverse events in patients with relapsed and/or refractory multiple myeloma receiving single-agent carfilzomib [0.03%]
卡非佐米单药治疗复发和/或难治多发性骨髓瘤患者的不良事件的发病率及处理措施：一项II期研究
R Donald Harvey
R Donald Harvey
Carfilzomib, a selective proteasome inhibitor approved in the USA in 2012, is a single agent for relapsed and refractory multiple myeloma. Carfilzomib is administered as a 2-10-minute infusion on days 1, 2, 8, 9, 15, and 16 of a 28-day cycl...