Analyzing the Efficacy and Potential Risks of Nitrous Oxide for Pain Management During Labor: A Narrative Review [0.03%]
笑气在分娩镇痛中有效性和潜在风险的疗效评价：叙述性文献回顾
Nikhita Kichili,Morgan K Brown,Devon S Armer et al.
Nikhita Kichili et al.
Nitrous oxide has been used worldwide for labor analgesia for over a century. It offers a non-invasive, rapidly acting, and self-administered option for pain and anxiety management. The present investigation examines efficacy, safety, and l...
Antifibrotic Strategies Targeting Phosphodiesterase-4 in Idiopathic Pulmonary Fibrosis: Molecular Mechanisms and Clinical Translation [0.03%]
特发性肺纤维化中靶向磷二酯酶-4的抗纤维化策略：分子机制与临床转化
Quan Ma,Shixin Zhou,Xiaodong Zhi et al.
Quan Ma et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterised by irreversible fibrosis of the lung parenchyma and a steady decline in respiratory function. Its pathogenesis remains incompletely unders...
The Role of Danavorexton for Perioperative Opioid-Induced Respiratory Depression and Sedation: A Narrative Review [0.03%]
围手术期丹沃克斯顿用于阿片类药物引起的呼吸抑制和镇静的药理作用：综述性文章
Alexia J Enache,Collin J Harris,Toluwanimi I Atewogbola et al.
Alexia J Enache et al.
Opioid-induced respiratory depression (OIRD) and sedation are significant perioperative complications that limit safe and effective use of opioid analgesia. Current reversal agents, such as naloxone, are effective at treating OIRD but may n...
The Emerging Role of Liposomal Bupivacaine in Erector Spinae Plane Blocks for Post-Operative Pain Management in Spine Surgeries: A Narrative Review [0.03%]
脂质体布比卡因在脊柱手术后 Erector Spinae 平面阻滞镇痛中作用的叙事性综述
Joseph B Delaney,Luke P Landry,Navy C Coggins et al.
Joseph B Delaney et al.
Postoperative pain is a common consequence of spinal operations related to tissue trauma, manipulation of neural structures, and lengthy procedures. While opioid medications are frequently used for pain control, their side effects, such as ...
Research Progress on the Clinical Application of Remimazolam Outside the Operating Room: A Review of Pharmacological Characteristics, Clinical Effects, and Safety [0.03%]
瑞玛唑仑院外临床应用研究进展：药理学特性、临床疗效及安全性综述
Hao Luo,Ce Zhou,YingDong Qu et al.
Hao Luo et al.
Remimazolam is a novel ultra-short-acting benzodiazepine sedative, which has shown great promise in clinical scenarios such as outpatient surgeries, endoscopic examinations, intensive care units, and emergency departments due to its rapid o...
Thomas Ward Fredrick,Michael Camilleri,Andres Acosta
Thomas Ward Fredrick
In this narrative review we describe the recent updates regarding anti-obesity medications as of February 2025. We describe the physiologic mechanisms underpinning the development of hunger, satiation, and maintenance of satiety to address ...
Monascus purpureus Red Yeast Rice: A Review of the in vitro and in vivo Pharmacological Activities, Studies in Humans, and Case Reports [0.03%]
红曲霉红麹红米：非临床活性、人体试验和案例报告综述
Resha Resmawati Shaleha,Anna Yuliana,Saeful Amin et al.
Resha Resmawati Shaleha et al.
Red yeast rice (RYR) is an Asian indigenous medicine that ferments Oryza sativa grains using the Monascus fungi, specifically Monascus purpureus. Monacolins, pigments, phenols, sterols, and benzopyrans, such as the mycotoxin citrinin, were ...
Bioactive Compounds From Saudi Arabian Fungi: A Systematic Review of Anticancer Potential [0.03%]
沙特阿拉伯真菌的生物活性化合物：抗癌潜力的系统评价
Sahar S Alghamdi,Jehan H Alamre,Arwa Alsubait et al.
Sahar S Alghamdi et al.
Cancer remains the second leading cause of death worldwide, highlighting the urgent need for novel therapeutic approaches. Fungi are a rich source of bioactive metabolites, some of which exhibit potent anticancer properties. This scoping re...
Metabolomics Insights into the Benefits of SGLT2 Inhibitors in Type 2 Diabetes [0.03%]
从代谢组学角度解读SGLT2抑制剂在2型糖尿病中的益处
Artemis Kyriakidou,Theocharis Koufakis,Helen Gika et al.
Artemis Kyriakidou et al.
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an established class of agents in the treatment of type 2 diabetes mellitus (T2DM), with proven cardiovascular and renal benefits. However, their precise m...
Determination of 5-Fluorouracil in Dried Blood Spots for Therapeutic Drug Monitoring and Adverse Event Assessment in Breast Cancer Patients [0.03%]
测定干血点中5-氟尿嘧啶以进行药物浓度监测和乳腺癌患者不良事件评估
Muthia Hanifah,Yahdiana Harahap,Denni Joko Purwanto
Muthia Hanifah
Background: 5-Fluorouracil (5-FU) is a chemotherapy drug used to treat breast cancer. Monitoring 5-FU levels in blood is essential due to its narrow therapeutic range, high individual variability, nonlinear pharmacokineti...