Exposure-response analysis to assess the concentration-QTc relationship of CC-122 [0.03%]
浓度-校正QT间期关系的暴露反应分析评估_CC-122的影响
Yan Li,Leonidas N Carayannopoulos,Michael Thomas et al.
Yan Li et al.
CC-122 hydrochloride is a novel pleiotropic pathway modifier compound that binds cereblon, a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex. CC-122 has multiple activities including modulation of immune cells, antiproli...
The effect of weight, body mass index, age, sex, and race on plasma concentrations of subcutaneous sumatriptan: a pooled analysis [0.03%]
体重、体质指数、年龄、性别和种族对皮下注射舒马曲坦后血浆浓度的影响：荟萃分析
Sagar Munjal,Anirudh Gautam,Alan M Rapoport et al.
Sagar Munjal et al.
Objective/background: Factors such as body size (weight and body mass index [BMI]), age, sex, and race might influence the clinical response to sumatriptan. We evaluated the impact of these covariates on the plasma concen...
Systematic review and network meta-analysis of stroke prevention treatments in patients with atrial fibrillation [0.03%]
房颤卒中预防治疗的系统评价和网络meta分析研究
Amy Tawfik,Joanna M Bielecki,Murray Krahn et al.
Amy Tawfik et al.
Background: In the last 4 years, four novel oral anticoagulants have been developed as alternatives to warfarin and antiplatelet agents for stroke prevention in atrial fibrillation (AF) patients. The objective of this rev...
Population pharmacokinetic modeling of glibenclamide in poorly controlled South African type 2 diabetic subjects [0.03%]
南非2型糖尿病患者的优降糖群体药动学模型研究
Virendra Rambiritch,Poobalan Naidoo,Breminand Maharaj et al.
Virendra Rambiritch et al.
Aim: The aim of this study was to describe the pharmacokinetics (PK) of glibenclamide in poorly controlled South African type 2 diabetic subjects using noncompartmental and model-based methods. ...
The treatment of type 2 diabetes in the presence of renal impairment: what we should know about newer therapies [0.03%]
肾功能不全合并2型糖尿病的治疗：我们应该了解的新疗法的相关知识
Melanie Davies,Sudesna Chatterjee,Kamlesh Khunti
Melanie Davies
Worldwide, an estimated 200 million people have chronic kidney disease (CKD), the most common causes of which include hypertension, arteriosclerosis, and diabetes. Importantly, ~40% of patients with diabetes develop CKD, yet evidence from m...
A randomized, double-blind, placebo-, and positive-controlled clinical pilot study to evaluate the efficacy and tolerability of standardized aqueous extracts of Terminalia chebula and Terminalia bellerica in subjects with hyperuricemia [0.03%]
Terminalia chebula和Terminalia bellerica标准化水提取物联合治疗高尿酸血症患者有效性和耐受性的随机双盲安慰剂阳性药对照临床试验
Pingali Usharani,Chandrasekhar Nutalapati,Venkata Kishan Pokuri et al.
Pingali Usharani et al.
Objectives: To evaluate the efficacy and tolerability of standardized aqueous extracts of Terminalia chebula and Terminalia bellerica versus febuxostat and placebo on reduction in serum uric acid levels in subjects with h...
Simultaneous administration of high-dose atorvastatin and clopidogrel does not interfere with platelet inhibition during percutaneous coronary intervention [0.03%]
高强度阿托伐他汀与氯吡格雷联用不会影响经皮冠状动脉介入治疗过程中的血小板抑制作用
Rolf P Kreutz,Jeffrey A Breall,Anjan Sinha et al.
Rolf P Kreutz et al.
Background: Reloading with high-dose atorvastatin shortly before percutaneous coronary interventions (PCIs) has been proposed as a strategy to reduce periprocedural myonecrosis. There has been a concern that statins that ...
Clinical use and applications of histone deacetylase inhibitors in multiple myeloma [0.03%]
组蛋白去乙酰化酶抑制剂在多发性骨髓瘤中的临床应用
Nidhi Tandon,Vijay Ramakrishnan,Shaji K Kumar
Nidhi Tandon
The incorporation of various novel therapies has resulted in a significant survival benefit in newly diagnosed and relapsed patients with multiple myeloma (MM) over the past decade. Despite these advances, resistance to therapy leads to eve...
Differential pharmacology and clinical utility of empagliflozin in type 2 diabetes [0.03%]
恩格列净在2型糖尿病中的药理学差异及临床应用价值
Kashif M Munir,Stephen N Davis
Kashif M Munir
With rates of obesity and diabetes rising across the world, effective therapies to treat hyperglycemia and its associated comorbidities continue to be in demand. Empagliflozin is a highly selective sodium glucose transporter-2 inhibitor tha...
Pharmacokinetic/pharmacodynamic analysis of teicoplanin in patients with MRSA infections [0.03%]
替考拉宁治疗耐甲氧西林金黄色葡萄球菌感染患者的药动/药效学分析研究
Kazuaki Matsumoto,Erika Watanabe,Naoko Kanazawa et al.
Kazuaki Matsumoto et al.
Background: Teicoplanin is a glycopeptide antibiotic that has been used to treat serious, invasive infections caused by Gram-positive bacteria. The area under the drug concentration-time curve (AUC)/minimum inhibitory con...