Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers [0.03%]
健康志愿者中食物对口服溶液和胶囊左旋多巴药代动力学影响的比较研究
D Alexander Oh,Neha Parikh,Varun Khurana et al.
D Alexander Oh et al.
Dronabinol is a pharmaceutical tetrahydrocannabinol originally developed as an oral capsule. A dronabinol oral solution was recently approved, and the effects of food on absorption and bioavailability of the oral solution versus capsules we...
Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in patients with dyslipidemia [0.03%]
巴豆、圣玛丽安姆和单链K及KA的高标准化合物对血脂异常患者的回顾性分析
Francesco Di Pierro,Pietro Putignano,Tarcisio Ferrara et al.
Francesco Di Pierro et al.
Background: Berberis aristata, because of its berberine content, and Monascus purpureus fermented rice, because of the presence of monacolins (naturally derived statins), are widely investigated food-grade ingredients use...
A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin [0.03%]
一项一期研究：评估年龄和体重对羟丙基-β-环糊精增溶的注射用diclofenac药代动力学影响的研究
Ronald Goldwater,William G Kramer,Douglas A Hamilton et al.
Ronald Goldwater et al.
Purpose: The analgesic and opioid-sparing effects of nonsteroidal anti-inflammatory drugs can be beneficial in postoperative populations. Hydroxypropyl-β-cyclodextrin (HPβCD)-diclofenac is an injectable formulation of d...
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis [0.03%]
一例孕妇因治疗妊娠剧吐而诱发的艾司奥美拉唑致肝损病例报告
Binny Thomas,Mahmoud Mohamed,Moza Al Hail et al.
Binny Thomas et al.
We report a case of 22-year-old primigravida presented to Women's Hospital - Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laborat...
A prospective, observational study comparing the PK/PD relationships of generic Meropenem (Mercide®) to the innovator brand in critically ill patients [0.03%]
一项前瞻性观察研究：比较重症患者中国产美罗培南(美平)仿制药与原研药的药物代谢动力学/效应动力学关系特征差异的研究
Mervyn Mer,Jacques Rene Snyman,Constance Elizabeth Jansen van Rensburg et al.
Mervyn Mer et al.
Introduction: Clinicians' skepticism, fueled by evidence of inferiority of some multisource generic antimicrobial products, results in the underutilization of more cost-effective generics, especially in critically ill pat...
LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives [0.03%]
LRRK2抑制剂及其在帕金森病治疗中的潜力：当前观点
Farzaneh Atashrazm,Nicolas Dzamko
Farzaneh Atashrazm
Major advances in understanding how genetics underlies Parkinson's disease (PD) have provided new opportunities for understanding disease pathogenesis and potential new targets for therapeutic intervention. One such target is leucine-rich r...
Eman Abd,Shereen A Yousef,Michael N Pastore et al.
Eman Abd et al.
The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the most appropriate setting in which to do the assessment i...
Bioavailability study of dronabinol oral solution versus dronabinol capsules in healthy volunteers [0.03%]
健康志愿者口服索利那新与奥昔布宁的药代动力学及耐受性对比研究
Neha Parikh,William G Kramer,Varun Khurana et al.
Neha Parikh et al.
Background: Dronabinol, a pharmaceutical Δ-9-tetrahydrocannabinol, was originally developed as an oral capsule. This study evaluated the bioavailability of a new formulation, dronabinol oral solution, versus a dronabinol...
Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects [0.03%]
南非Ⅱ型糖尿病患者的格列本脲药代动力学/药效学模型研究
Virendra Rambiritch,Poobalan Naidoo,Goonaseelan Pillai
Virendra Rambiritch
Aim: To determine the effective dose of glibenclamide by quantifying the dose-response relationship in South African type 2 diabetic patients. Patients an...
Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives [0.03%]
囊性纤维化跨膜传导调节剂在囊性纤维化中的应用：目前的视角
Béla Z Schmidt,Jérémy B Haaf,Teresinha Leal et al.
Béla Z Schmidt et al.
Mutations of the CFTR gene cause cystic fibrosis (CF), the most common recessive monogenic disease worldwide. These mutations alter the synthesis, processing, function, or half-life of CFTR, the main chloride channel expressed in the apical...