Thomas Müller
Thomas Müller
Heterogeneous expression of neurotransmitter deficits results from onset and progression of Parkinson's disease. Intervals, characterized by reappearance of motor and associated certain nonmotor symptoms, determine the end of good tolerabil...
Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy [0.03%]
抗糖尿病药物Pramlintide在结直肠癌中具有抗肿瘤作用，并与常规化疗协同作用
Maha S Al-Keilani,Dua H Alsmadi,Ruba S Darweesh et al.
Maha S Al-Keilani et al.
Background: Approximately 90% of patients with metastatic colorectal cancer fail therapy mainly due to resistance. Taking advantage of currently approved agents for treatment of disease conditions other than cancer for th...
Pavel Klein,Anyzeila Diaz,Teresa Gasalla et al.
Pavel Klein et al.
Brivaracetam (BRV; Briviact) is a new antiepileptic drug (AED) approved for adjunctive treatment of focal (partial-onset) seizures in adults. BRV is a selective, high-affinity ligand for synaptic vesicle 2A (SV2A) with 15- to 30-fold higher...
Dave Singh,Arjun Ravi,Thomas Southworth
Dave Singh
Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) binds to prostaglandin D2. CRTH2 is expressed on various cell types including eosinophils, mast cells, and basophils. CRTH2 and prostaglandin D2 are involved in all...
Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma [0.03%]
奥拉单抗：一种血小板衍生生长因子受体-α阻断抗体，用于治疗软组织肉瘤
Alexandra Pender,Robin L Jones
Alexandra Pender
The outcome of patients with unresectable or metastatic soft tissue sarcoma (STS) remains poor with few treatment options. A number of randomized trials in the first-line setting have shown no difference in overall survival between combinat...
Tiziana Vavalà
Tiziana Vavalà
Lung cancer treatment has considerably changed over the last few years: the identification of druggable oncogenic alterations and innovative immunotherapic approaches granted lung cancer patients the possibility of more efficient and less t...
Population pharmacokinetics of pomalidomide in patients with relapsed or refractory multiple myeloma with various degrees of impaired renal function [0.03%]
不同程度肾功能损害的复发难治多发性骨髓瘤患者中泊马西平的群体药代动力学
Yan Li,Xiaomin Wang,Edward O&#x;Mara et al.
Yan Li et al.
Pomalidomide is an immunomodulatory drug for treatment of relapsed or refractory multiple myeloma (rrMM) in patients who often have comorbid renal conditions. To assess the impact of renal impairment on pomalidomide exposure, a population p...
Assessment of prescribed medications and pattern of distribution for potential drug-drug interactions among chronic kidney disease patients attending the Nephrology Clinic of Lagos University Teaching Hospital in Sub-Saharan West Africa [0.03%]
拉各斯大学教学医院肾病门诊慢性肾脏病患者处方药物评估及潜在药物相互作用分布规律的分析
Olumuyiwa John Fasipe,Peter Ehizokhale Akhideno,Obiyo Nwaiwu et al.
Olumuyiwa John Fasipe et al.
Introduction: Life expectancy has increased significantly among chronic kidney disease (CKD) patients due to the extensive use of polypharmacy practice for medication prescriptions. This predisposes them to potential drug...
Possible involvement of ROS generation in vorinostat pretreatment induced enhancement of the antibacterial activity of ciprofloxacin [0.03%]
ROS生成参与伏立诺他诱导的左氧氟沙星抗菌活性增强作用的可能性
Majed M Masadeh,Karem H Alzoubi,Sayer I Al-Azzam et al.
Majed M Masadeh et al.
The mechanism underlying ciprofloxacin action involves interference with transcription and replication of bacterial DNA and, thus, the induction of double-strand breaks in DNA. It also involves elevated oxidative stress, which might contrib...
Antipsychotic prescription to identify delirium: results from two cohorts [0.03%]
抗精神病药处方识别谵妄：来自两队列的结果
Kristin M Zimmerman,Allison M Paquin,James L Rudolph
Kristin M Zimmerman
Objectives: Detection of delirium in hospitalized patients remains challenging. The objective was to determine if the prescription of antipsychotic medications was associated with delirium. ...