Mechanisms and the clinical relevance of complex drug-drug interactions [0.03%]
药物相互作用的复杂性及其临床意义机制研究
Arthur G Roberts,Morgan E Gibbs
Arthur G Roberts
As a result of an increasing aging population, the number of individuals taking multiple medications simultaneously has grown considerably. For these individuals, taking multiple medications has increased the risk of undesirable drug-drug i...
Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin [0.03%]
利用双特异信号肽-药物偶联物靶向人横纹肌肉瘤、骨肉瘤和卵巢腺癌中的EGFR和uPAR
Felix Oh,Deborah Todhunter,Elizabeth Taras et al.
Felix Oh et al.
Purpose: Human sarcomas are rare and difficult to treat cancerous tumors typically arising from soft tissue or bone. Conversely, carcinomas are the most common cancer subtype in humans and the primary cause of mortality a...
Pharmacokinetics of evocalcet in secondary hyperparathyroidism patients receiving hemodialysis: first-in-patient clinical trial in Japan [0.03%]
依考卡塞在血液透析治疗继发性甲状旁腺功能亢进症患者中的药动学：日本首次人体临床试验
Takashi Shigematsu,Ryutaro Shimazaki,Masafumi Fukagawa et al.
Takashi Shigematsu et al.
Purpose: Cinacalcet is a positive allosteric modulator of calcium-sensing receptors in the parathyroid gland and an effective treatment for secondary hyperparathyroidism. However, this agent has considerable side effects ...
A Phase I, open-label, randomized, crossover study in healthy subjects to evaluate the bioavailability of, and the food effect on, a pomalidomide oral liquid suspension [0.03%]
一项在健康受试者中评估泊马西尼口服液体制剂生物利用度和食物效应的I期、开放标签、随机交叉研究
Yan Li,Liangang Liu,Lian Huang et al.
Yan Li et al.
Objective: The aim of this study was to evaluate the bioavailability of a pomalidomide oral liquid suspension relative to the commercial capsule formulation and to assess the food effect on the pomalidomide oral liquid su...
Safety and neutralizing rabies antibody in healthy subjects given a single dose of rabies immune globulin caprylate/chromatography purified [0.03%]
人用狂犬病免疫球蛋白（辛酸/层析精制）单剂量使用的安全性及中和抗体滴度研究
Kim Hanna,Maria Cristina Cruz,Elsa Mondou et al.
Kim Hanna et al.
Background: Rabies immune globulin (RIG) and vaccination series are necessary for postexposure prophylaxis. A new formulation of RIG (human) purified by caprylate/chromatography (RIG-C) was evaluated. ...
Pharmacokinetic evaluation of D-ribose after oral and intravenous administration to healthy rabbits [0.03%]
口服和静脉给药后，D核糖在健康家兔体内的药代动力学评价
Karem H Alzoubi,Zuhair Bani Ismail,Mohamed K Al-Essa et al.
Karem H Alzoubi et al.
Introduction: This study explored D-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits. Materials and methods: ...
Erratum: A randomized direct comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban [Corrigendum [0.03%]
对阿哌沙班与利伐沙班的药代动力学和药效学的随机直接比较研究的勘误表[勘误]
[This corrects the article on p. 179 in vol. 6, PMID: 25419161.].
Anti-factor Xa levels in obese patients receiving enoxaparin for treatment and prophylaxis indications [0.03%]
肥胖患者在接受依诺肝素治疗和预防时的抗因子Xa水平研究
Linda Tahaineh,Sahar M Edaily,Shadi F Gharaibeh
Linda Tahaineh
Objectives: To evaluate the degree of anticoagulation achieved with different enoxaparin dosing regimens used in obese and morbidly obese patients in a hospital setting in Jordan. ...
Distribution of pomalidomide into semen of healthy male subjects after multiple doses [0.03%]
多次给药后 Pomalidomide 在健康男性精液中的分布
Yan Li,Xiaomin Wang,Liangang Liu et al.
Yan Li et al.
Objective: To assess whether pomalidomide can distribute into human semen and its duration in human semen. Method: A phase 1, randomize...
Pharmacokinetic equivalence study of nonsteroidal anti-inflammatory drug etoricoxib [0.03%]
选择性环氧合酶-2抑制剂埃托考昔片的人体药代动力学等效研究
Raymond R Tjandrawinata,Arini Setiawati,Dwi Nofiarny et al.
Raymond R Tjandrawinata et al.
Purpose: The current study aimed to evaluate whether a generic product of etoricoxib 120 mg film-coated tablet (the test drug) was bioequivalent to the reference product (Arcoxia® film-coated tablet 120 mg). ...